A5081088313- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Health and Mental Health
- Coronary Interventions and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Frailty in Older Adults
- Atrial Fibrillation Management and Outcomes
- Healthcare Policy and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Aortic aneurysm repair treatments
- Dialysis and Renal Disease Management
- Healthcare cost, quality, practices
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
- Acute Kidney Injury Research
- Health disparities and outcomes
- Cardiac and Coronary Surgery Techniques
- Medical Coding and Health Information
University of Alberta
2016-2025
University of Waterloo
2024-2025
Keele University
2024
Alberta Hospital Edmonton
2011-2023
Canadian VIGOUR Centre
2016-2023
Society of Interventional Radiology
2022
Vanderbilt University Medical Center
2022
Kingston Health Sciences Centre
2021
University of Calgary
2002-2021
O'Brien Institute
2019-2021
Abstract Background: Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial due to ischemia that occurs during or within 30 days surgery. The study’s four objectives were determine the diagnostic criteria, characteristics, predictors, and 30-day outcomes of MINS. Methods: In this international, prospective cohort study 15,065 patients aged 45 yr older who underwent in-patient surgery, troponin T measured first 3 postoperative days. Patients with a...
There is substantial variability in the perioperative administration of aspirin patients undergoing noncardiac surgery, both among who are already on an regimen and those not.Using a 2-by-2 factorial trial design, we randomly assigned 10,010 were preparing to undergo surgery at risk for vascular complications receive or placebo clonidine placebo. The results reported here. stratified according whether they had not been taking before study (initiation stratum, with 5628 patients)...
Marked activation of the sympathetic nervous system occurs during and after noncardiac surgery. Low-dose clonidine, which blunts central outflow, may prevent perioperative myocardial infarction death without inducing hemodynamic instability.We performed a blinded, randomized trial with 2-by-2 factorial design to allow separate evaluation low-dose clonidine versus placebo aspirin in patients with, or at risk for, atherosclerotic disease who were undergoing A total 10,010 135 centers 23...
Background — Elderly patients with ischemic heart disease are increasingly referred for coronary artery bypass grafting (CABG) or percutaneous intervention (PCI). However, reports of poor outcomes in the elderly have led to questions about benefit these strategies. We studied survival by prescribed treatment (CABG, PCI, medical therapy) 3 age categories: <70 years, 70 79 and ≥80 years age. Methods Results The Alberta Provincial Project Outcomes Assessment Coronary Heart Disease (APPROACH)...
Frailty is superior to chronological age as a predictor of outcome. The Edmonton Frail Scale (EFS) simple valid measure frailty, covering multiple important domains, with scores ranging from 0 (not frail) 17 (very frail). purpose this pilot study was assess the EFS in group elderly patients acute coronary syndrome (ACS).The administered 183 consecutive ACS aged ≥ 65 years admitted single centre Edmonton, Alberta, Canada.Scores ranged 0-13. Patients higher were older, more comorbidities,...
Obesity is a pervasive problem and popular subject of academic assessment. The ability to take advantage existing data, such as administrative databases, study obesity appealing. objective our was assess the validity coding in an database compare association between outcomes versus registry. This conducted using coronary catheterization registry (Discharge Abstract Database (DAD)). A Body Mass Index (BMI) ≥30 kg/m2 within defined obesity. In DAD by diagnosis codes E65 – E68 (ICD-10)....
Background: Uncertainty remains about the effects of aspirin in patients with prior percutaneous coronary intervention (PCI) having noncardiac surgery. Objective: To evaluate benefits and harms perioperative PCI. Design: Nonprespecified subgroup analysis a multicenter factorial trial. Computerized Internet randomization was done between 2010 2013. Patients, clinicians, data collectors, outcome adjudicators were blinded to treatment assignment. (ClinicalTrials.gov: NCT01082874) Setting: 135...
<h3>Importance</h3> Guidelines currently recommend ticagrelor over clopidogrel for patients with acute coronary syndrome (ACS) based on randomized clinical trial data in which reduced major adverse events (MACE) vs but increased bleeding and dyspnea. <h3>Objective</h3> To compare the risk of MACE ACS treated percutaneous intervention (PCI), to dyspnea, evaluate association between P2Y<sub>12</sub>inhibitor adherence MACE. <h3>Design, Setting, Participants</h3> Population-based cohort study...
Excess deaths during the COVID-19 pandemic compared with those expected from historical trends have been unequally distributed, both geographically and socioeconomically. Not all excess directly related to infection. We investigated geographical socioeconomic patterns in for major groups of underlying causes pandemic.
Background Deaths in the first year of Coronavirus Disease 2019 (COVID-19) pandemic England and Wales were unevenly distributed socioeconomically geographically. However, full scale inequalities may have been underestimated to date, as most measures excess mortality do not adequately account for varying age profiles deaths between social groups. We measured years life lost (YLL) attributable pandemic, directly or indirectly, comparing across geographic socioeconomic Methods findings used...
Importance Contrast-associated acute kidney injury (AKI) is a common complication of coronary angiography and percutaneous intervention (PCI) that has been associated with high costs adverse long-term outcomes. Objective To determine whether multifaceted effective for the prevention AKI after or PCI. Design, Setting, Participants A stepped-wedge, cluster randomized clinical trial was conducted in Alberta, Canada, included all invasive cardiologists at 3 cardiac catheterization laboratories...
BACKGROUND: Coronary artery bypass grafting (CABG) is the recommended mode of revascularization in patients with ischemic left ventricular dysfunction (iLVSD) and multivessel disease. However, contemporary percutaneous coronary intervention (PCI) outcomes have improved integration novel technologies refinement strategies, PCI often used clinical practice this population. There a lack evidence from randomized trials comparing state-of-the-art versus CABG for treatment iLVSD This was impetus...
Treatment of patients with cancer presenting ST-elevation myocardial infarction (STEMI) is complex given the increased risk both thrombotic and major bleeding complications. A nationally linked cohort STEMI between January 2005 March 2019 was obtained from UK Myocardial Infarction National Audit Project Hospital Episode Statistics Admitted Patient Care registries. The primary outcomes were re-infarction at 1 year following admission STEMI. Major defined as events that require hospital...
Although there have been substantial medical advances that improve the outcomes following cardiac ischemic events, gender differences in treatment and course of recovery for patients with coronary artery disease (CAD) continue to exist. There is a general paucity data comparing health related quality life (HRQOL) men women undergoing CAD. The purpose this study was compare HRQOL Alberta, at one-year initial catheterization, after adjustment known demographic, co-morbid, severity predictors...
Surnames have the potential to accurately identify ancestral origins as they are passed on from generation generation. In this study, we developed and validated a Chinese surname list define ethnicity.We conducted literature review, panel telephone survey in randomly selected sample Canadian city 2003 develop list. The was then data Community Health Survey. Both surveys collected information self-reported ethnicity surname.Of 112,452 people analyzed Survey, 1.6% were Chinese. This similar...