A5055720479- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Nutritional Studies and Diet
- Cardiac Health and Mental Health
- Alzheimer's disease research and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Dementia and Cognitive Impairment Research
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
- Cardiac electrophysiology and arrhythmias
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Disaster Response and Management
- Pharmaceutical Practices and Patient Outcomes
- Patient Safety and Medication Errors
University of Ottawa
2023-2025
Hospital Clínico San Carlos
2024
Universidad Complutense de Madrid
2024
Haute École Robert Schuman
2024
Montreal Heart Institute
2022-2023
Université de Montréal
2019-2023
Centre Hospitalier de l’Université de Montréal
2019-2022
BACKGROUND: Injection of contrast media for rapid measurement fractional flow reserve (cFFR) obviates the side effects and time requirements adenosine (aFFR) improves diagnostic performance relative to nonhyperemic pressure ratios. However, studies cFFR have had variable delivery contrast. We evaluated using an automated injector with a standardized volume rate reference standard aFFR. METHODS: The ACCELERATION study (Adenosine Contrast Correlations in Evaluating Revascularization) is...
Abstract Heart failure (HF) is associated with morbidity, rehospitalization and polypharmacy. The incidence rate of mortality in HF patients polypharmacy poorly studied. We examine the association risk incident hospitalized a primary diagnosis after discharge from hospital using Quebec administrative databases, Canada 1999 to 2015. Polypharmacy, cardiovascular (CV) non-CV were respectively defined as exposure ≥ 10 drugs, 5 CV drugs within three months prior case or control selection date....
Women and the elderly with ST-elevation myocardial infarction (STEMI) experience longer treatment delays despite prehospital STEMI diagnosis catheterization laboratory activation systems. It is not known what role specific referral systems might play in mediating this gap care. We therefore examined sex- age-based differences delay (TD) different systems.This observational comparative effectiveness study comprised 3 retrospective cohorts: a traditional hospital-based cohort (Cohort 1), an...
Background The effectiveness of vascular closure devices (VCDs) to reduce bleeding after transfemoral percutaneous coronary intervention remains unsettled. Methods and Results Participants in the REGULATE-PCI (Effect REG1 anticoagulation system versus bivalirudin on outcomes intervention) trial who underwent with VCD implantation were compared those manual compression. primary end point was type 2, 3, or 5 Bleeding Academic Research Consortium access site at day 3. Univariate multivariate...
The link between cardiovascular (CV) risk factors or diseases and dementia is documented. There conflicting evidence whether age moderates the association. We need to study this gap so that research clinical initiatives target appropriate groups. A cohort of 320,630 adult patients without was built using Quebec healthcare databases (1998-2010). CV were hypertension, diabetes dyslipidemia, while included stroke, myocardial infarction (MI), chronic heart failure (HF), atrial fibrillation (AF)....
The objective is to assess the comparative effectiveness and safety of dual-antiplatelet therapy (DAPT) vs triple (TT) with DAPT + oral anticoagulant (OAC) in patients anterior ST-segment elevation myocardial infarction (STEMI) new-onset anterior/apical wall-motion abnormalities (WMAs) treated primary percutaneous coronary intervention (PCI).
BackgroundObese patients are underrepresented in clinical trials assessing the comparative effectiveness and safety of use direct oral anticoagulants vs atrial fibrillation (AF) patients.MethodsUsing data from Quebec provincial administrative databases, for years2010-2017, we created a retrospective cohort with inpatient or outpatient coding AF obesity who were newly prescribed an anticoagulant. The primary outcome was composite intracranial, gastrointestinal, major bleeding other sites,...
Abstract Background The management of atrial fibrillation and flutter (AF) patients undergoing percutaneous coronary intervention (PCI) has undergone a rapid recent evolution. In 2016, the Canadian Cardiovascular Society (CCS) published expert recommendations to help guide clinicians in balancing bleeding thrombotic risks these patients. Hypothesis Antithrombotic regimen prescriptions for AF PCI evolved after publication 2016 CCS guidelines. Methods A prospective cohort with placement stent...
Balancing the effects of dual antiplatelet therapy (DAPT) in era potent purinergic receptor type Y, subtype 12 (P2Y12) inhibitors remains a challenge management acute coronary syndrome (ACS). We conducted systematic review and meta-analysis following 2-stage process consisting searching for reviews published between 2019 November 2022. included randomized controlled trials (RCTs) ACS patients treated with percutaneous intervention comparing (i) ticagrelor- vs prasugrel-based DAPT (ii) P2Y12...
BackgroundST-elevation myocardial infarction diagnosis at first medical contact (FMC) and prehospital cardiac catheterization laboratory (CCL) activation are associated with reduced total ischemic time therefore have become the dominant ST-elevation referral method in primary percutaneous coronary intervention systems. We sought to determine whether physician oversight was improved diagnostic performance a CCL system what effect additional interpretation has on treatment delay.MethodsBetween...
BackgroundThe management of atrial fibrillation and flutter (AF) patients undergoing percutaneous coronary intervention (PCI) has evolved rapidly in the past decade. We determine whether publication 2016 Canadian Cardiovascular Society AF guidelines were associated with a shift practice patterns.MethodsUsing Quebec provincial administrative database information for period from 2010-2017, retrospective cohort inpatient or outpatient coding AF, who subsequently underwent PCI placement stent,...
Abstract The link between cardiovascular (CV) risk factors or diseases and dementia is documented. There conflicting evidence whether age moderates the association. We need to study this gap so that research clinical initiatives target appropriate groups. A cohort of 320,630 adult patients without was built using Quebec healthcare databases (1998–2010). CV were hypertension, diabetes dyslipidemia, while included stroke, myocardial infarction (MI), chronic heart failure (HF), atrial...
In patients with anterior ST-elevation myocardial infarction (STEMI) and new-onset antero-apical wall motion abnormalities (WMAs), whether the rate of prophylaxis against left ventricular thrombus outcomes differ between men women is unknown. A multicentre retrospective cohort study STEMI WMAs treated primary percutaneous coronary intervention was conducted. Patients an established indication oral anticoagulation (OAC) were excluded. The rates triple therapy (double antiplatelet + OAC) at...
Despite the availability of technologies and guidelines recommendations, invasive coronary function testing (IFT) remains underperformed in patients with ischemia no obstructive artery disease (INOCA), but current state IFT Canadian cardiac catheterization laboratories (CCL) remained unknown. Therefore, we conducted an survey among CCL directors(n=46). While most directors believed that should be performed INOCA experience persisting symptoms or adverse clinical outcomes, only 19.6% (n=9)...