Diane Heels‐Ansdell
A5009424802- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Venous Thromboembolism Diagnosis and Management
- Nosocomial Infections in ICU
- Bone fractures and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Heparin-Induced Thrombocytopenia and Thrombosis
- Meta-analysis and systematic reviews
- Atrial Fibrillation Management and Outcomes
- Orthopaedic implants and arthroplasty
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Acute Myocardial Infarction Research
- Pelvic and Acetabular Injuries
- Sepsis Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Trauma and Emergency Care Studies
- Ethics in Clinical Research
- Aortic aneurysm repair treatments
- Palliative Care and End-of-Life Issues
- Family and Patient Care in Intensive Care Units
- Clostridium difficile and Clostridium perfringens research
- Central Venous Catheters and Hemodialysis
- Surgical site infection prevention
- Acute Ischemic Stroke Management
McMaster University
2016-2025
Impact
2017-2025
Hamilton Health Sciences
2009-2024
Population Health Research Institute
2020-2024
University of Maryland, Baltimore
2024
Centre hospitalier universitaire de Québec
2013-2024
McMaster University Medical Centre
2023
Department of Health Research
2022
St. Joseph’s Healthcare Hamilton
2005-2021
London Health Sciences Centre
2020-2021
Of the 200 million adults worldwide who undergo noncardiac surgery each year, more than 1 will die within 30 days.To determine relationship between peak fourth-generation troponin T (TnT) measurement in first 3 days after and 30-day mortality.A prospective, international cohort study that enrolled patients from August 6, 2007, to January 11, 2011. Eligible were aged 45 years older required at least an overnight hospital admission having surgery.Patients' TnT levels measured 6 12 hours on 1,...
Abstract Background: Myocardial injury after noncardiac surgery (MINS) was defined as prognostically relevant myocardial due to ischemia that occurs during or within 30 days surgery. The study’s four objectives were determine the diagnostic criteria, characteristics, predictors, and 30-day outcomes of MINS. Methods: In this international, prospective cohort study 15,065 patients aged 45 yr older who underwent in-patient surgery, troponin T measured first 3 postoperative days. Patients with a...
Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality myocardial injury after noncardiac surgery (MINS).To determine association hsTnT potential diagnostic criteria for MINS (ie, due to ischemia associated with mortality).Prospective cohort study of patients aged 45 years or older who underwent inpatient had a postoperative measurement. Starting in October 2008, participants were recruited at 23 centers 13...
Among adults undergoing contemporary noncardiac surgery, little is known about the frequency and timing of death associations between perioperative complications mortality. We aimed to establish its association with complications.We conducted a prospective cohort study patients aged 45 years older who underwent inpatient surgery at 28 centres in 14 countries. monitored for until 30 days after determined relation these 30-day mortality using Cox proportional hazards model.We included 40 004...
<h3>Importance</h3> Growing interest in microbial dysbiosis during critical illness has raised questions about the therapeutic potential of microbiome modification with probiotics. Prior randomized trials this population suggest that probiotics reduce infection, particularly ventilator-associated pneumonia (VAP), although probiotic-associated infections have also been reported. <h3>Objective</h3> To evaluate effect of<i>Lactobacillus rhamnosus</i>GG on preventing VAP, additional infections,...
Whether proton-pump inhibitors are beneficial or harmful for stress ulcer prophylaxis in critically ill patients undergoing invasive ventilation is unclear.
Studies evaluating surgical-site infection have had conflicting results with respect to the use of alcohol solutions containing iodine povacrylex or chlorhexidine gluconate as skin antisepsis before surgery repair a fractured limb (i.e., an extremity fracture).
Background: Preliminary data suggest that preoperative N-terminal pro–B-type natriuretic peptide (NT-proBNP) may improve risk prediction in patients undergoing noncardiac surgery. Objective: To determine whether NT-proBNP has additional predictive value beyond a clinical score for the composite of vascular death and myocardial injury after surgery (MINS) within 30 days Design: Prospective cohort study. Setting: 16 hospitals 9 countries. Patients: 10 402 aged 45 years or older having...
Stress ulcer prophylaxis (SUP) is commonly prescribed in the intensive care unit. However, data from systematic reviews and conventional meta-analyses are limited by imprecision restricted to direct comparisons. We conducted a network meta-analysis of randomized clinical trials (RCTs) examine safety efficacy drugs available for SUP critically ill patients. searched MEDLINE, EMBASE, Cochrane Library Central Register Controlled Trials through April 2017 controlled that examined proton pump...
Objectives To determine if coronary computed tomographic angiography enhances prediction of perioperative risk in patients before non-cardiac surgery and to assess the preoperative anatomy who experience a myocardial infarction after surgery. Design Prospective cohort study. Setting 12 centers eight countries. Participants 955 with, or at of, atherosclerotic disease underwent Interventions Coronary was performed preoperatively; clinicians were blinded results unless left main suspected....
Objectives: To identify risk factors for failure of anticoagulant thromboprophylaxis in critically ill patients the ICU. Design: Multivariable regression analysis thrombosis predictors from a randomized trial. Setting: Sixty-seven medical-surgical ICUs six countries. Patients: Three thousand seven hundred forty-six patients. Interventions: All received with low-molecular-weight heparin or unfractionated at standard doses. Measurements and Main Results: Independent venous thromboembolism,...