A5026485973- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Pancreatitis Pathology and Treatment
- Cancer Cells and Metastasis
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Cancer, Stress, Anesthesia, and Immune Response
- TGF-β signaling in diseases
- Organ Transplantation Techniques and Outcomes
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- Lipid metabolism and disorders
- Immune Cell Function and Interaction
- Cancer, Lipids, and Metabolism
- Machine Learning in Healthcare
- Signaling Pathways in Disease
- Colorectal and Anal Carcinomas
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Artificial Intelligence in Healthcare
- Organ Donation and Transplantation
- Appendicitis Diagnosis and Management
- Sepsis Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Glioma Diagnosis and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Guangdong Provincial People's Hospital
2023-2024
Third Affiliated Hospital of Southern Medical University
2024
Southern Medical University
2021-2023
Sepsis is a life-threatening disease associated with high mortality rate, emphasizing the need for exploration of novel models to predict prognosis this patient population. This study compared performance traditional logistic regression and machine learning in predicting adult sepsis mortality. To develop an optimum model patients based on comparing methodology. Retrospective analysis was conducted 606 inpatients at our medical center between January 2020 December 2022, who were randomly...
Nearly 40 y have passed since the 1983 National Institutes of Health Consensus-Development-Conference, which has turned liver transplantation (LT) from a clinical experiment into routine therapeutic modality. Since' LT changed substantially. We aimed to comprehensively analyze publication trends in most-cited top-notch literature science over 4-decade period.
Perineural invasion (PNI) is considered to be a main reason for the poor prognosis of pancreatic cancer. In present study, we analyzed roles substance P (SP)/neurokinin-1 receptor (NK-1R) and lncRNA LOC389641 in cancer PNI. Pancreatic cell lines BxPC-3 MIAPaCa-2 were cocultured with SH-SY5Y cells then stimulated SP simulate vivo influence ganglia on The transfected neurokinin-1 overexpression vector, NK-1R silencing or respectively. proliferative abilities assessed using counting kit-8...
Acute pancreatitis (AP) is a common surgical acute abdomen. Different kinds of may have different pathophysiological characteristics each other. The objective this research was to investigate the early clinical features and complications types pancreatitis. 787 AP patients admitted in Huadu District People's Hospital Guangzhou during January 2009 December 2019 were analyzed retrospectively. Among patients, 520 (66.1%) biliary (group I), 69 (8.7%) alcoholic II), 198 (25.2%)...
DNA methylation patterns have been found to be distinct between tumor and normal patients. However, the effect of demethylation enzymes, ten eleven translocation (TET) proteins, has not comprehensively characterized in liver cancer. In this research, we sought unravel linkage TET proteins with prognosis, immune characteristics biological pathways hepatocellular carcinoma (HCC).
Background: Peptidylarginine deiminase 1 (PADI1) has been reported to promote tumorigenesis in breast cancer. However, the functional role of PADI1 pancreatic ductal adenocarcinoma (PAAD) remained elusive until now.
Objective: Pancreatic adenocarcinoma (PAAD) is a highly malignant gastrointestinal tumor with almost similar morbidity and mortality. In this study, based on bioinformatics, we investigated the role of gene methylation in PAAD, evaluated relevant factors affecting patient prognosis, screened potential anti-cancer small molecule drugs, constructed prediction model to assess prognosis PAAD. Methods: Clinical genomic data PAAD were collected from Tumor Genome Atlas Project (TCGA) database...
Background: Oxidative stress is involved in regulating various biological processes human cancers. However, the effect of oxidative on pancreatic adenocarcinoma (PAAD) remained unclear. Methods: Pancreatic cancer expression profiles from TCGA were downloaded. Consensus ClusterPlus helped classify molecular subtypes based PAAD prognosis-associated genes. Limma package filtered differentially expressed genes (DEGs) between subtypes. A multi-gene risk model was developed using Lease absolute...
Hypertriglyceridemia-induced severe acute pancreatitis (HTG-SAP) is a type of characterized by an abnormal elevation plasma triglyceride. HTG-SAP has been associated with various complications and high mortality rate. In this study, we established nomogram for predicting the overall survival (OS) patients during hospitalization.
Background. Pancreatic adenocarcinoma (PAAD) shows significantly high mortality. Transforming growth factor-beta (TGF-β) signaling plays an important role in tumorigenesis and development. A prognostic model was conducted using transforming for predicting PAAD prognosis guiding personalized therapies. Methods. Datasets were grouped into test training sets. Univariate Cox regression analysis least absolute shrinkage selection operator (LASSO) applied introduced identifying genes associated...
Abstract Background Pancreatic cancer is a deadly disease with low overall survival during the past 30 years. Perineural invasion (PNI) was considered to be main reason for poor prognosis. In present study, we analyzed role of substance P (SP)/neurokinin-1 receptor (NK-1R) and long non-coding RNA (lncRNA) LOC389641 on pancreatic PNI. Material methods cell lines BxPC-3 MIAPaCa-2 were co-cultured SHSY5Y cells, then stimulated SP simulate in vivo influence by ganglion. The co-culture cells...
Abstract Background Peptidylarginine deiminase 1 (PADI1) may be relative with the progression of epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PAAD). We aim to explore role PADI1 PAAD. Methods The expression pattern PAAD tissues and normal was analyzed using Cancer Genome Atlas (TCGA) dataset. knocked down CFPAN-1 HPAC cells, while overexpressed PANC-1 Bxpc-3 cells by RNA interference. Wound healing assay performed analyze cell migration distance. Cell invasion...