A5101438118- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- Structural Analysis and Optimization
- Textile materials and evaluations
- Glycosylation and Glycoproteins Research
- Microwave and Dielectric Measurement Techniques
- Bacteriophages and microbial interactions
- Silicon Carbide Semiconductor Technologies
- Paraquat toxicity studies and treatments
- Civil and Geotechnical Engineering Research
- Renal Diseases and Glomerulopathies
- Photoacoustic and Ultrasonic Imaging
- Robotic Locomotion and Control
- Machine Learning and Data Classification
- Digital Imaging for Blood Diseases
- Pharmacovigilance and Adverse Drug Reactions
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Power Systems and Technologies
- Blasting Impact and Analysis
- Coordination Chemistry and Organometallics
- Drug-Induced Hepatotoxicity and Protection
Zhejiang Hospital
2025
Hangzhou Hospital of Traditional Chinese Medicine
2025
Academy of Military Medical Sciences
2020-2024
Hebei University
2023
Soochow University
2023
Huaian First People’s Hospital
2023
Nanjing Medical University
2023
Capital Medical University
2023
Wuhan Institute of Technology
2022
Chinese Academy of Agricultural Sciences
2022
An air-insulated microfluidic chip was designed for the automatic centrifugal distribution of samples to 24-test cells, enabling parallel identification multiple clinical pneumonia-related pathogens in 1.45-μL reactions without cross-contamination 45 min. A portable nucleic acid analyzer that integrates mechanical, confocal optical, electronic, and software functions also developed collect fluorescence data a Ø3 mm imaging field near optical diffraction limit highly sensitive detection...
Acute myocardial infarction (AMI) is the single leading cause of worldwide mortality and morbidity. Heart-type fatty acid-binding protein (H-FABP) cardiac troponin I (cTnI), as biomarkers emerging at different stages AMI, have complementary advantages in terms specificity sensitivity. Therefore, we developed a magnetic immunoassay method based on surface-enhanced Raman scattering (SERS) to detect H-FABP cTnI simultaneously. Herein, two mutually independent reporter molecules were embedded...
Au-4MBA@Ag with a strong Raman signal was successfully synthesized, and combination magnetic separation technology achieved sensitive detection of cTnI.
<title>Abstract</title> This randomized, open-label, two period, treatment, fasting bioequivalence trial was conducted to demonstrate the between riluzole tablets manufactured by Jiangsu Enhua Pharmaceutical Co., Ltd. and reference preparations from Sanofi Winthrop Industry (certified Mature IP) in healthy individuals. OBJECTIVE: The study aimed compare pharmacokinetic parameters evaluate of both when taken on an empty stomach. Additionally, safety profile assessed population. METHODS:...
<title>Abstract</title> Objective: This study aimed to investigate the characteristics of hepatic injury induced by tocilizumab through FDA Adverse Event Reporting System (FAERS) database, which highlights need for close monitoring liver function during clinical use. Additionally potential toxicological mechanisms are explored drug-gene interaction network analysis. Methods: Liver reports associated with were collected from database (from June 2014 2024) using Odds Ratio (ROR) and...
A novel electrochemical biosensor for detecting pathogenic bacteria was designed based on specific magnetic separation and highly sensitive click chemistry.
Abstract Sepsis is a systemic inflammatory response syndrome caused by infection. The mortality rate as high 30%−50%. Early diagnosis and treatment can significantly improve the of patients with sepsis. Therefore, we have developed SERS-based magnetic immunoassay method that uses principle sandwich to quantitatively detect Interleukin 6 (IL-6) Procalcitonin (PCT). In this article, two different Raman reporter molecules are embedded in middle Au@Ag shell coupled tracer antibody form SERS...
Amphetamine (AMP), as a psychiatric drug acting on the central nervous system, and has become one of most common drugs abuse in illegal market at present, which adversely affects social public safety. We developed SERS magnetic immunoassay with high sensitivity, specificity, rapid quantitative detection AMP. synthesized intensity substrate (Au-XP013@Ag) using "hot spot" effect combined it antibodies to form immunotags (Au-XP013@Ag-AMP-mAb). Subsequently, carboxyl beads were linked label...
Conventional inorganic semiconductor nanoparticles have emerged as photothermal agents in therapy and sonosensitizers sonodynamic therapy. However, their weak drug-loading capabilities the deficient techniques for multifunctional limit applications. A bismuth-based gold-crowned nanocomposite (BACN) was rationally designed successfully synthesized could then be used to prepare nanoplatforms with excellent biocompatibilities synergistic real-time imaging. Because of constituent gold pyridine,...
DNA usually adsorbs gold nanoparticles by virtue of mercapto or amino groups at one end a molecule. However, in this paper, we report sensitive biosensor constructed using unmodified molecules with consecutive adenines (CA DNA) and (GNPs). The CA DNA–GNP composite was fabricated on electrodes characterized scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) the method. Using an quartz crystal microbalance (EQCM), mechanism which GNPs combined also studied....
Sepsis is a systemic inflammatory response syndrome caused by infection, and common disease in intensive care units (ICUs), whereby the mortality rate as high 30% to 50%. Early diagnosis treatment can significantly reduce of patients with sepsis. We have developed method based on SERS for rapid quantitative detection IL-6. Using principle double antibody sandwich, core-shell nanoparticles embedded Raman reporter (Au@4MBA@Ag NPs) are coupled tracer antibody, while biotin was capture form an...
As common psychotropic drugs, ketamine (KET) and amphetamine (AMP) are often consumed by drug users at the same time, which seriously threatens people's health. Therefore, study of simultaneous detection methods for KET AMP is imperative. In this study, a novel method in serum was established on basis surface-enhanced Raman scattering (SERS). The antibodies were attached Au@Ag core-shell nanoparticles embedded with different reporters as substrates. labelled antigens KET-BSA AMP-BSA linked...
In a complex traffic environment, predicting the trajectory of surrounding vehicles in driver's line sight can greatly reduce possibility various accidents and play an auxiliary role decision making. The motion predicted is constrained by that is, adjacent relative spatial positions between vehicles. This paper mainly studies behavior prediction on expressway. Based social convolutional pooling LSTM network (CS-LSTM), CS-LSTM with attention mechanism proposed, which assigns different weights...
The selectins interact in important normal and pathological situations with certain sialylated, fucosylated glycoconjugate ligands containing sialyl Lewisx (Neu5Acα2–3Galβ1–4(Fuc-α1–3)GlcNAc). Much effort has gone into the synthesis of sialylated sulfated analogs as competitive for selectins. Since natural selectin GlyCAM-1 PSGL-1 carry part a branched Core 2 O-linked structure, we recently synthesized Galβ1–4(Fuc-α1–3)GlcNAcβ1–6(SE-3Galβ1–3)GalNAc1αOMe found it to be moderately superior...
A novel sensitive chemiluminescence (CL) system ([Ag(HIO6)2]5--luminol reaction system), coupled with a flow injection, is introduced for determination of d-penicillamine. The based on the enhancement effect by penicillamine in alkaline medium. Under optimum conditions, CL intensity proportional to concentrations d-penicillamine good linearity. linear range covers 1.5-150 ng mL-1 and limit detection method 0.8 mL-1. relative standard deviation 0.23% 11 repeated measurements 0.06 µg has been...
The purpose of this paper is to establish a method for easy operation, high sensitivity, strong anti-interference ability, and rapid quantitative detection cardiac fatty acid-binding protein in acute myocardial infarction biomarkers, so that it can be quickly diagnosed at an early stage provide basis further treatment. Based on the SERS principle, traditional sandwich system generated by reaction was captured streptavidin (SA) magnetic beads through specific SA biotin then enriched applied...
A new method was constructed for detecting dopamine based on aptamer-specific recognition and resonance Rayleigh scattering (RRS) of G - quadruplex nanowires (G wires). The aptamer used to recognize the target dopamine, Exonuclease III applied cleave hairpin DNA, wire formation induced in presence K+ Mg2+. This phenomenon confirmed by polyacrylamide gel electrophoresis. Thus, a quantitative relationship between RRS intensity wires concentration established. experimental conditions were...