A5079346370- Thermal Regulation in Medicine
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Heat shock proteins research
- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- Electromagnetic Fields and Biological Effects
- Wireless Body Area Networks
- Circular RNAs in diseases
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Spaceflight effects on biology
- Effects of Radiation Exposure
- Nanoplatforms for cancer theranostics
- Fatty Acid Research and Health
- Intracerebral and Subarachnoid Hemorrhage Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Surface Treatment and Coatings
- Molecular Communication and Nanonetworks
- Circadian rhythm and melatonin
- Magnesium Alloys: Properties and Applications
- Viral gastroenteritis research and epidemiology
- Glioma Diagnosis and Treatment
Tianjin Hospital
2020
First Affiliated Hospital of Chinese PLA General Hospital
2006-2016
Kyoto University
1998-1999
The usage of mobile phone increases globally. However, there is still a paucity data about the impact electromagnetic fields (EMF) on human health. This study investigated whether EMF radiation would alter biology glial cells and act as tumor-promoting agent. We exposed rat astrocytes C6 glioma to 1950-MHz TD-SCDMA for 12, 24 48 h respectively, found that exposure had differential effects astroctyes cells. A damaged mitochondria induced significant apoptosis astrocytes. Moreover, caspase-3,...
Abnormal expression of SOCS3 has been implicated in myeloproliferative neoplasms, but the role pathogenesis leukemia remains largely unknown. Here, we examined function growth and chemo-sensitivity chronic myeloid (CML) explored involved mechanisms.Expression levels several cell lines bone marrow mononuclear cells (BMNCs) from CML patients were determined using quantitative real-time PCR (qPCR) Western blotting (WB). The roles proliferation, apoptosis, drug resistance by clonogenic...
The increase in mobile phone use has generated concerns about possible risks to human health, especially the development of brain tumors. Whether tumor patients should continue telephones remained unclear because a paucity information. Herein, we investigated whether electromagnetic fields from phones could alter biological features cells and act as tumor-promoting agent. Human glioblastoma cell lines, U251-MG U87-MG, were exposed 1950-MHz time division-synchronous code division multiple...
Background Lung adenocarcinoma (LAC) is the most prominent histological subtype of non‐small cell lung cancer (NSCLC) with a high rate mortality and metastasis. Accumulating evidence has shown that long non‐coding RNAs (lncRNAs) play malfunctioning roles in development human tumors. Hence, this study aimed to determine biological function LINC00511 LAC provide novel diagnostic therapeutic target for it. Methods expression tissues lines (H1299 A549) were detected by real time‐polymerase chain...
Background The RNA-binding motif protein 3 (RBM3), which is transcriptionally induced by low temperature and hypoxia, has recently been found to be upregulated in human tumors. However, its expression status astrocytoma not well defined. This article focuses on the differential of RBM3 astrocytomas different grades normal brain tissues. Methods was detected tissues quantitative real-time PCR, immunohistochemistry, Western blotting. Analysis variance performed data from PCR. Fisher's exact...
Suppressor of cytokine signaling 3 (SOCS3) plays an important role in mice fetal liver erythropoiesis, but the roles SOCS3 human hematopoietic stem cells (HSCs) have not been well investigated. In present study, lentiviral small interference RNA expression vectors (shRNA) were constructed and stably transferred into HSCs. We found that knockdown induced erythroid expansion Conversely, Ectopic progenitor blocked colony formation To further explore involved mechanism, we compared gene profiles...
Abstract Background Cerebral vasospasm (CVS) is a common serious complication after the spontaneous subarachnoid hemorrhage (SAH). Despite recent advances in medical and surgical treatments, 30-day mortality rate of SAH remains high, there lack especially effective clinical treatment to alleviate improve CVS. The present study has investigated therapeutic effect insulin vitamin C on CVS SAH. Results Five days SAH, obvious basilar artery spasm group, whose average vascular cross-sectional...
Objective The expression cold-inducible RNA-binding protein (CIRP) is significantly enhanced in neurons under hypothermia,but its roles remain unclear.This study aims to investigate whether the cerebral protection hypothermia mediated by CIRP-mediated inhibition of neuronal apoptosis.Methods Primary rat cortical were isolated,cultured,and transduced with lentiviral CIRP-RNAi.Apoptosis was induced 100 μmol/L H2O2.The treated cells divided into two groups,and cultured 37℃ or 32℃ incubator...
环境温度明显改变时.生物体会产生某种蛋白来调节机体功能,以适应温度变化.如当温度明显增高时.热休克蛋白(heat shock proteins,HSPs)表达会明显增高.除了适应环境温度升高外,HSPs在常温下也会表达.并且有很多基因调控功能[1]。