A5034901562- Mesenchymal stem cell research
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Birth, Development, and Health
- Gastrointestinal disorders and treatments
- Cancer-related molecular mechanisms research
- Composite Structure Analysis and Optimization
- Gastrointestinal Tumor Research and Treatment
- Cardiovascular Health and Risk Factors
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Circadian rhythm and melatonin
- PARP inhibition in cancer therapy
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Myocardial Infarction Research
- Organ Transplantation Techniques and Outcomes
- Esophageal and GI Pathology
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Plant Stress Responses and Tolerance
- Nonlocal and gradient elasticity in micro/nano structures
- Cerebrovascular and Carotid Artery Diseases
- Angiogenesis and VEGF in Cancer
- Pediatric Urology and Nephrology Studies
- Cell death mechanisms and regulation
The Synergetic Innovation Center for Advanced Materials
2025
Yili Normal University
2023-2025
Nanjing University of Science and Technology
2013-2025
Nanjing University of Posts and Telecommunications
2025
Jinan University
2016-2024
Pudong New Area People's Hospital
2017-2023
Southern University of Science and Technology
2019-2023
University of Alabama at Birmingham
2018-2023
Nanjing Medical University
2012-2022
ShenZhen People’s Hospital
2015-2022
Abstract Background Hyperlipidemia plays a crucial role in the development and progression of coronary artery disease (CAD). Recent studies have identified that microRNAs (miRNAs) are important regulators lipid metabolism, but little is known about circulating levels lipometabolism-related miRNAs their relationship with presence CAD patients hyperlipidemia. Methods In present study, we enrolled total 255 hyperlipidemia or without 100 controls normal blood lipids. The plasma four miRNAs,...
Background Human amniotic membrane-derived mesenchymal stem cells (hAMCs) have the potential to reduce heart and lung fibrosis, but whether could liver fibrosis remains largely unknown. Methodology/Principal Findings Hepatic cirrhosis model was established by infusion of CCl4 (1 ml/kg body weight twice a week for 8 weeks) in immunocompetent C57Bl/6J mice. hAMCs, isolated from term delivered placenta, were infused into spleen at 4 weeks after mice challenged with CCl4. Control received only...
Hydrogen sulfide (H2S) and matrix metallopeptidase 2 (MMP-2) are inextricably linked in the occurrence development of diseases treatment diseases. However, most activatable imaging probes currently developed single-locked that do not simultaneously detect H2S MMP-2 levels at disease sites severely hinder real-time accurate analysis dynamic relationship between two interrelated biomarkers. Herein, we report a dual-locked H2S/MMP-2-activatable near-infrared (NIR) fluorescent probe through...
Baicalin is a bioactive ingredient extracted from the root of Scutellariae radix, which used to treat ulcerative colitis (UC).We investigated activity baicalin on lipopolysaccharide-stimulated RAW264.7 cells and 2,4,6-trinitrobenzene sulfonic acid-induced rats, including attenuation oxidant stress apoptosis.The severity was assessed by disease index. The activities catalase (CAT), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), content malondialdehyde (MDA) were determined their...
To establish and internally validate an innovative R.I.R.S. scoring system that allows urologists to preoperatively estimate the stone-free rate (SFR) after retrograde intrarenal surgery (RIRS). This study included 382 eligible samples from a total 573 patients who underwent RIRS January 2014 December 2016. Four reproducible factors in system, including renal stone density, inferior pole stone, infundibular length burden, were measured based on preoperative computed tomography of urography...
MicroRNA-34a (miR-34a) is a direct transcriptional target of p53, and downregulated in several different types cancer. However, the underlying mechanism miR-34a effects colorectal cancer not well understood. In this study, we explored role cell invasion, migration, apoptosis. Transient overexpression SW480 cells caused severe decrease migration invasion (both, p<0.05) compared to control groups. Combining transfection with 5-fluorouracil (5-FU) treatment further enhanced inhibition 5-FU...
Treatment with the chemotherapeutic agent, doxorubicin (DOX), is limited by side effects. We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model. The present study to investigated possible protective effect of on DOX-induced nephrotoxicity.
Bone marrow stem cells are able to repair infarcted human myocardium following intracoronary transplantation via the infarct‐relative artery. However, traditional reperfusion strategies fail open artery in some patients, making effective delivery impossible. Our previous study demonstrated a safe and efficient approach delivering bone noninfarcted an animal myocardial infarction model. The objective of present was evaluate safety feasibility autologous mesenchymal cell such patients with...
Kidney function follows a 24-h rhythm subject to regulation by circadian genes including the transcription factor Bmal1. A high-salt diet induces phase shift in Bmal1 expression renal inner medulla that is dependent on endothelin type B (ET ) receptors. Furthermore, ET receptor-mediated natriuresis sex dependent. Therefore, experiments tested hypothesis collecting duct regulates blood pressure sex-dependent manner. We generated mouse model lacks duct, where receptor abundance highest. Male,...
Neovascularization and the formation of collateral vessels are often impaired in diabetes mellitus (DM) population compared with non-diabetics. Alterations vascular endothelial growth factor (VEGF) signaling nitric oxide synthase (eNOS) dysfunction have been confirmed to play a crucial role neovascularization diabetic mice. Accumulating data suggested that Rg1, main component Panax ginseng, has ability promote tubulogenesis human umbilical vein cells (HUVECs) vitro, mechanism involves...
Highlights•ScRNA-seq of pancreatic islets comparing virgin, pregnant, and postpartum mice•Islet cell types exhibit unique transcriptomic responses in pregnancy postpartum•β-cells show induction immediate early genes (IEGs) postpartum•IEGs β-cells do not correlate with apoptosis may mediate survivalSummaryPancreatic β-cell mass expands during regresses the period conjunction dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these...
BACKGROUND Multiple endocrine neoplasias (MENs) are a group of hereditary diseases involving multiple glands, and their prevalence is low. MEN type 1 (MEN1) has diverse clinical manifestations, mainly the parathyroid gastrointestinal tract, pancreas pituitary gland, making it easy to miss diagnosis. CASE SUMMARY We present case patient in whom MEN1 was detected early. A middle-aged male with recurrent abdominal pain diarrhea admitted hospital. Blood tests at admission revealed hypercalcemia...
The frequency and buckling characteristics of functional gradient (FG) beams with asymmetric material distribution in the temperature field are analyzed this paper. Generally, asymmetrical FG results a non-zero neutral axis thermal moment. However, some previous studies adopted treatment homogeneous which moment were set as zero. To end, comprehensive beam model effect is developed based on absolute nodal coordinate formulation, Euler–Bernoulli theory, Lagrangian strain, exact curvature,...
In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in mouse model and attempted to elucidate mechanism involved. Mice subjected unilateral ligation of left anterior renal pedicle were divided into four groups: (1) control group, (2) CI-AKI induced by contrast media (CM group), (3) plus low-dose fasudil (LD group) (4) high-dose (HD group). Animals from groups 2-4 received iodixanol (4.0 g...
Circulating endothelial progenitor cells (EPCs) play a key role in restoring function and enhancing angiogenesis. However, the effects of low-dose aspirin on circulating EPCs are not well known. We investigated EPC migration, adhesion, senescence, proliferation, apoptosis nitric oxide synthase (eNOS) expression. migration was detected by modified Boyden chamber assay. adhesion assay performed counting adherent fibronectin-coated culture dishes. senescence assessed both...
SUMO‐specific protease 2 (SENP2) is a deSUMOylation that plays an important role in the regulation of transforming growth factor‐β (TGF‐β) signaling. Aberrant TGF‐β signaling common human cancers and contributes to tumor metastasis by inducing epithelial‐mesenchymal transition (EMT). In previous studies, we demonstrated SENP2 suppresses bladder cancer cell migration invasion. However, little known about whether inhibits EMT regulating progression. Here, investigated vitro vivo. We found...
Long non-coding small nucleolar RNA host gene 7 (lncRNA SNHG7) is located on chromosome 9q34.3 in length of 984 bp. SNHG7 has been found to play the role oncogene varieties cancers, and its dysregulation be associated with carcinogenesis progression. In present study, we examined expression prostate cancer tissues paired adjacent normal tissues, further explored clinical significance prognostic value patients.A total 127 were collected from patients who underwent radical prostatectomy...