A5100333800- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Advanced Breast Cancer Therapies
- Prostate Cancer Treatment and Research
- Lipid metabolism and disorders
- Cytokine Signaling Pathways and Interactions
- Circular RNAs in diseases
- Frailty in Older Adults
- Emergency and Acute Care Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Older Adults Driving Studies
- Chronic Disease Management Strategies
- Pleural and Pulmonary Diseases
- Metabolism, Diabetes, and Cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune cells in cancer
- Intensive Care Unit Cognitive Disorders
- PI3K/AKT/mTOR signaling in cancer
- Cardiac Arrest and Resuscitation
University of Alabama at Birmingham
2015-2025
Nanjing University of Science and Technology
2025
Affiliated Hospital of Southwest Medical University
2020-2025
Zhejiang Chinese Medical University
2025
Hubei University of Medicine
2021-2025
Guangzhou University
2024
Rapport (United States)
2024
Watanabe Applied Technology (Brazil)
2024
Kennedy Center
2024
Walker (United States)
2024
Abstract Fibrinogen is an extracellular matrix protein composed of three polypeptide chains with fibrinogen alpha (FGA), beta (FGB) and gamma (FGG). Although its related fragments are involved in tumor angiogenesis metastasis, their functional roles incompatible. A recent genome-scale screening reveals that loss FGA affects the acceleration growth metastasis lung cancer, but mechanism remains elusive. We used CRISPR/Cas9 genome editing to knockout (KO) human adenocarcinoma (LUAD) cell lines...
To assess the presence of brain and systemic inflammation in subjects newly diagnosed with Parkinson's disease (PD).Evidence for a pathophysiologic role PD is growing. However, several key gaps remain as to PD, including extent immune activation at early stages, potential effects treatments on whether pro-inflammatory signals are associated clinical features and/or predict more rapid progression.We enrolled de novo (n = 58) age-matched controls 62). Subjects underwent assessments, Movement...
ABSTRACT Background Axillary lymph node burden(ALNB) is a critical factor in determining treatment strategies for clinical T 1 –T 2 (cT ) stage breast cancer. However, as ALNB assessment relies on invasive procedures, exploring non‐invasive methods essential. Purpose To develop and validate habitat radiomics model assessing cT cancer, incorporating radiogenomic data to improve interpretability. Study Type Retrospective. Population 468 patients with cancer from two institutions The Cancer...
The GH binding protein (GHBP), which exists in many vertebrates, is a circulating high affinity corresponding to the extracellular domain of receptor (GHR). In humans, rabbits, and several other species, GHBP generated by proteolysis GHR shedding its domain. We previously showed that inducible phorbol ester 12-myristate,13-acetate (PMA) inhibited metalloprotease inhibitor, Immunex Corp. Compound 3 (IC3). metzincin metalloprotease, tumor necrosis factor-α (TNF-α)-converting enzyme (TACE),...
The Clinical Dementia Rating (CDR) is a well-validated instrument widely used to detect and stage dementia due Alzheimer disease. digital Electronic (eCDR) can be remotely self-administered automatically scored, with potential facilitate efficient screening staging.To evaluate the association of eCDR CDR other in-clinic assessments for older adults cognitive impairment.This multisite, cross-sectional study baseline data from longitudinal, observational 2020 2023, including up 3 years...
Passive acoustic monitoring serves as a minimally invasive and effective method for biodiversity assessment, particularly in bird through the application of indices. However, use different recording devices types environmental noise (e.g., rain, wind, stream, traffic noise) lead to signal distortions that affect ecoacoustics Currently, there are no established guidelines specifying technical requirements signal-to-noise ratio (SNR) threshold accurate calculation To enhance accuracy indices...
The β‐amyloid precursor protein (βAPP) undergoes a physiological cleavage triggered by one or several proteolytic activities referred to as α‐secretases, leading the secretion of sAPPα. Several lines evidence indicate that α‐secretase is highly regulated process. Thus, besides constitutive production sAPPα, studies have reported on kinase C‐regulated sAPPα secretion. Studies aimed at identifying α‐secretase(s) candidates suggest involvement enzymes belonging pro‐hormone convertases and...
The binding of permethrin (PE) with calf thymus DNA (ctDNA) in physiological buffer (pH 7.4) was investigated by ultraviolet-visible (UV-vis) absorption, fluorescence, circular dichroism (CD), and Fourier transform infrared (FT-IR) spectroscopy merging multivariate curve resolution-alternating least-squares (MCR-ALS) chemometrics approach. MCR-ALS applied to resolve the combined spectroscopic data matrix, which obtained UV-vis fluorescence methods. concentration profiles PE, ctDNA, PE-ctDNA...
GH receptor (GHR) and prolactin (PRL) (PRLR) are structurally similar cytokine superfamily members that highly conserved among species. has growth-promoting metabolic effects in various tissues vertebrates, including humans. PRL is essential for regulation of lactation mammals. Recent studies indicate breast tissue bears GHR PRLR both may impact development or behavior cancer cells. An important facet human (hGH) (hPRL) biology although hPRL interacts only with hPRLR, hGH binds well to hGHR...
Pregnancy in rodents is associated with a two- to threefold increase β-cell mass, which attributable large increases proliferation, complimented by size, survival, and function mediated mainly the lactogenic hormones prolactin (PRL) placental lactogens. In humans, however, mass does not as dramatically during pregnancy, PRL fails activate proliferation human islets vitro. To determine why, we explored PRL–prolactin receptor (hPRLR)–Janus kinase 2 (JAK2)–signal transducer activator of...
In the last few years, accumulating evidence has indicated that numerous long noncoding RNAs (lncRNAs) are abnormally expressed in gastric cancer (GC) and associated with survival of GC patients. This study aimed to conduct a meta-analysis on 19 lncRNAs (AFAP1 antisense RNA 1 [AFAP1-AS1], CDKN2B [ANRIL], susceptibility 15 [CASC15], colon transcript 2 [CCAT2], adenocarcinoma associated, positive CD44 regulator, intergenic [GAPLINC], H19, imprinted maternally [H19], HOX [HOTAIR], HOXA distal...
Growth hormone (GH) initiates its cellular action by properly dimerizing GH receptor (GHR). A substantial fraction of circulating is complexed with a high-affinity GH-binding protein (GHBP) that in many species can be generated GHR proteolysis and shedding the receptor's ligand-binding extracellular domain. We previously showed this 1) acutely promoted phorbol ester 12-myristate 13-acetate (PMA), 2) requires metalloprotease activity, 3) generates both shed GHBP membrane-associated...
GH and prolactin (PRL) are structurally related hormones that exert important effects in disparate target tissues. Their receptors (GHR PRLR) reside the cytokine receptor superfamily share signaling pathways. In humans, binds both GHR PRLR, whereas PRL only PRLR. Both their may be relevant certain human rodent cancers, including breast cancer. promote T47D cancer cells express Furthermore, PRLR associate a fashion augmented acutely by GH, even though primarily activates rather than GHR,...
Previous articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time patients gastric cancer (GC). A systematic review and meta-analysis was performed to study the outcome it.Meta-analysis.English studies estimating miRNAs any curves in GC were identified up till March 19, 2017 through performing online searches PubMed, EMBASE, Web Science Cochrane Database Systematic Reviews by two authors independently. The pooled hazard ratios (HR) 95% confidence...
The reconstruction of pulmonary vascular structure caused by the proliferation and migration arterial smooth muscle cells (PASMCs) is central link in formation hypertension (PAH). Platelet‑derived growth factor (PDGF) can regulate PASMCs. At same time, nuclear factor activated T cells (NFATs) plays an important role development PAH. To best our knowledge, there are no reports yet regarding whether PDGF regulates NFATc2 to increase present study aimed investigate affects...
Ovarian cancer (OV) is the most lethal form of gynecological malignancy worldwide, with limited therapeutic options and high recurrence rates. However, research focusing on prognostic patterns ferroptosis-related genes (FRGs) in ovarian still lacking. From 6,406 differentially expressed (DEGs) between TCGA-OV ( n = 376) GTEx cohort 180), we identified 63 potential genes. Through LASSO-penalized Cox analysis, 3 genes, SLC7A11, ZFP36, TTBK2, were finally distinguished. The time-dependent ROC...
Small airway fibrosis is a key pathological process accompanying chronic obstructive pulmonary disease (COPD) and includes fibroblast/myofibroblast transdifferentiation excessive extracellular matrix deposition. Ginsenoside Rg1, one of the main active ingredients Panax ginseng , has been shown to exert an antifibrotic effect in many tissues. However, little known about underlying mechanism whether ginsenoside Rg1 can on small fibrosis. We investigated anti-small effects human embryonic lung...
// Yue Zhang 1 , Chao Wei Cong-Cong Guo Rong-Xiu Bi 2 Jin Xie Dong-Hui Guan Chuan-Hua Yang 3 and Yue-Hua Jiang 4 First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong, People's Republic China Department Orthopedics, Affiliated Hospital 250011, Cardiology, Central Laboratory, Correspondence to: Jiang, email: jiang_yuehua@hotmail.com Keywords: microRNA, hepatocellular carcinoma, prognosis, meta-analysis Received: May 14, 2017 Accepted:...