Rachel L. Nosheny
A5079745650- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Cognitive Functions and Memory
- Obsessive-Compulsive Spectrum Disorders
- Advanced Neuroimaging Techniques and Applications
- Patient-Provider Communication in Healthcare
- Autism Spectrum Disorder Research
- Eating Disorders and Behaviors
- Nerve injury and regeneration
- Down syndrome and intellectual disability research
- Machine Learning in Healthcare
- Frailty in Older Adults
- Technology Use by Older Adults
- Health disparities and outcomes
- Social Media in Health Education
- Neurological Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
- HIV Research and Treatment
- Health Literacy and Information Accessibility
- Neurogenesis and neuroplasticity mechanisms
- Health Policy Implementation Science
San Francisco VA Medical Center
2016-2025
University of California, San Francisco
2016-2025
Advanced Imaging Research (United States)
2021-2025
University of California System
2023-2025
Northern California Institute for Research and Education
2017-2025
Alzheimer’s Disease Neuroimaging Initiative
2022-2024
United States Department of Veterans Affairs
2013-2023
Authorised Association Consortium
2023
Landscape Research Group
2023
Union Bank of Switzerland
2023
Abstract Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core ADNI has been to improve methods for clinical trials disease (AD) and related disorders. Methods We review contributions MRI from present past cycles (ADNI‐1, ‐Grand Opportunity ‐2). also plans future‐ADNI‐3. Results Contributions include creating standardized acquisition protocols quality control methods; examining effect...
The gap between chronological age (CA) and biological brain age, as estimated from magnetic resonance images (MRIs), reflects how individual patterns of neuroanatomic aging deviate their typical trajectories. MRI-derived (BA) estimates are often obtained using deep learning models that may perform relatively poorly on new data or lack interpretability. This study introduces a convolutional neural network (CNN) to estimate BA after training the MRIs 4,681 cognitively normal (CN) participants...
Recruitment, assessment, and longitudinal monitoring of participants for neuroscience studies clinical trials limit the development new treatments. Widespread Internet use allows data capture from in an unsupervised setting. The Brain Health Registry, a website online registry, collects their study partners.
Characterization of early tau deposition in individuals with preclinical Alzheimer disease (AD) is critical for prevention trials that aim to select at risk AD and halt the progression disease.To evaluate prevalence cortical positron emission tomography (PET) heterogeneity a large cohort clinically unimpaired older adults elevated β-amyloid (A+).This cross-sectional study examined prerandomized PET, amyloid structural magnetic resonance imaging, demographic, cognitive data from Anti-Amyloid...
Dementia assessment includes cognitive and behavioral testing with informant verification. Conventional is resource-intensive, uneven access. Online unsupervised assessments could reduce barriers to risk assessment. The aim of this study was assess the relationship between informant-rated changes participant-completed neuropsychological test performance in older adults, both measured remotely via an online platform, Brain Health Registry (BHR).Observational cohort study.Community-dwelling...
Importance Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset (LOAD), but it remains unclear whether increased WMH along the AD continuum reflective of AD-intrinsic processes or secondary to elevated systemic vascular risk factors. Objective To estimate associations neurodegeneration parenchymal vessel amyloidosis with accumulation investigate associated beyond these...
Remote, internet-based methods for recruitment, screening, and longitudinally assessing older adults have the potential to facilitate Alzheimer's disease (AD) clinical trials observational studies.
Abstract Mechanisms of resilience against tau pathology in individuals across the Alzheimer’s disease spectrum are insufficiently understood. Longitudinal data necessary to reveal which factors relate preserved cognition (i.e. cognitive resilience) and brain structure despite abundant pathology, clarify whether these associations cross-sectional or longitudinal. We used a longitudinal study design investigate role several demographic, biological structural yielding as measured with PET. In...
Brain age (BA), distinct from chronological (CA), can be estimated MRIs to evaluate neuroanatomic aging in cognitively normal (CN) individuals. BA, however, is a cross-sectional measure that summarizes cumulative since birth. Thus, it conveys poorly recent or contemporaneous trends, which better quantified by the (temporal) pace P of brain aging. Many approaches map , rely on quantifying DNA methylation whole-blood cells, blood–brain barrier separates neural cells. We introduce...
Abstract Introduction The purpose of this study is to compare online neuropsychological test performance older adults across self‐reported diagnoses being cognitively normal, mild cognitive impairment, and dementia due Alzheimer's disease determine the association memory concerns family history on performance. Methods Participants completed Cogstate Brief Battery unsupervised at home. Results Data from 6463 participants over age 55 years were analyzed. Adults with diagnosis impairment...
Abstract Plasma phosphorylated-tau181 (p-tau181) showed the potential for Alzheimer’s diagnosis and prognosis, but its role in detecting cerebral pathologies is unclear. We aimed to evaluate whether it could serve as a marker pathology brain. A total of 1189 participants with plasma p-tau181 PET data amyloid, tau or FDG were included from ADNI. Cross-sectional relationships biomarkers tested. Longitudinally, we further investigated different levels at baseline predicted progression...
Abstract A biological research framework to define Alzheimer’ disease with dichotomized biomarker measurement was proposed by National Institute on Aging–Alzheimer’s Association (NIA–AA). However, it cannot characterize the hierarchy spreading pattern of tau pathology. To reflect in vivo progression using biomarker, we constructed a refined topographic 18 F-AV-1451 PET staging scheme longitudinal clinical validation. Seven hundred and thirty-four participants baseline (baseline age 73.9 ±...
The poor generalizability of clinical research data due to the enrollment highly educated, non-Latinx White participants hampers development therapies for Alzheimer's disease (AD). Black and Latinx older adults have a greater risk dementia, yet it is unclear how health-care disparities sociocultural factors influence potential AD prognosis. Low under-represented populations may be attributable several including exclusion higher rates comorbidities, lower access clinics, legacy unethical...
An analysis of the ethnocultural and socioeconomic composition Alzheimer's Disease Neuroimaging Initiative (ADNI) participants is needed to assess generalizability ADNI data diverse populations.
The Clinical Dementia Rating (CDR) is a well-validated instrument widely used to detect and stage dementia due Alzheimer disease. digital Electronic (eCDR) can be remotely self-administered automatically scored, with potential facilitate efficient screening staging.To evaluate the association of eCDR CDR other in-clinic assessments for older adults cognitive impairment.This multisite, cross-sectional study baseline data from longitudinal, observational 2020 2023, including up 3 years...
The effect of β-amyloid (Aβ) accumulation on regional structural brain changes in early stages Alzheimer disease (AD) is not well understood.To test the hypothesis that development Aβ pathology related to increased atrophy brains cognitively normal (CN) persons.Longitudinal clinicobiomarker cohort study involving 47 CN control subjects and 15 patients with AD dementia. All participants underwent repeated cerebrospinal fluid Aβ42 magnetic resonance imaging measurements for up 4 years....
β-amyloid (Aβ) plaque accumulation is a hallmark of Alzheimer's disease (AD). It believed to start many years prior symptoms and reflected by reduced cerebrospinal fluid (CSF) levels the peptide Aβ1-42 (Aβ42). Here we tested hypothesis that baseline CSF proteins involved in microglia activity, synaptic function Aβ metabolism predict development plaques, assessed longitudinal Aβ42 decrease cognitively healthy people. Forty-six people with three four serial samples were included (mean...
Clinical trials in Alzheimer's disease are aimed at early stages of disease, including preclinical disease. The high cost and time required to screen large numbers participants for Aβ pathology impede the development novel drugs. This study's objective was evaluate extent which inexpensive easily obtainable information can reduce number failures by increasing proportion Aβ+ identified screening.We used random forest models positive predictive value demographics, APOE, longitudinal cognitive...