A5032770351- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Health, Environment, Cognitive Aging
- Bioinformatics and Genomic Networks
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Brain Tumor Detection and Classification
- Traumatic Brain Injury Research
- Neural dynamics and brain function
- Medical Image Segmentation Techniques
- Genetic Associations and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mental Health Research Topics
- Cerebrovascular and Carotid Artery Diseases
- Neurogenesis and neuroplasticity mechanisms
- MRI in cancer diagnosis
- Metabolomics and Mass Spectrometry Studies
Boston University
2015-2024
Alzheimer’s Disease Neuroimaging Initiative
2014-2024
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
Center for Systems Biology
2023
Cohort (United Kingdom)
2023
University School
2011-2022
Framingham Heart Study
2021
King's College London
2021
Humboldt-Universität zu Berlin
2021
Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) is a longitudinal multisite observational study of healthy elders, mild cognitive impairment (MCI), and disease. Magnetic resonance imaging (MRI), (18F)‐fluorodeoxyglucose positron emission tomography (FDG PET), urine serum, cerebrospinal fluid (CSF) biomarkers, as well clinical/psychometric assessments are acquiredat multiple time points. All data will be cross‐linked made available to the general scientific community. purpose...
We used magnetic resonance imaging (MRI) measurements to determine whether persons in the prodromal phase of Alzheimer's disease (AD) could be accurately identified before they developed clinically diagnosed dementia. Normal subjects (n = 24) and those with mild memory difficulty 79) received an MRI scan at baseline were then followed annually for 3 years which individuals subsequently met clinical criteria AD. Patients AD also evaluated 16). Nineteen 79 "converted" a diagnosis probable...
<b><i><i>Background:</i></i></b> MRI measures of the entorhinal cortex and hippocampus have been used to predict which nondemented individuals with memory problems will progress meet criteria for AD on follow-up, but their relative accuracy remains controversial. <b><i><i>Objectives:</i></i></b> To compare predicting who develop AD. <b><i><i>Methods:</i></i></b> volumes were obtained in 137 comprising four groups: 1) normal cognition both at baseline after 3 years follow-up (n = 28), 2)...
Abstract Functional magnetic resonance imaging (fMRI) was used to study memory‐associated activation of medial temporal lobe (MTL) regions in 32 nondemented elderly individuals with mild cognitive impairment (MCI). Subjects performed a visual encoding task during fMRI scanning and were tested for recognition stimuli afterward. MTL interest identified from each individual's structural MRI, quantified within region. Greater extent the hippocampal formation parahippocampal gyrus (PHG)...
Recent studies have indicated that brain atrophy is more closely associated with cognitive impairment in multiple sclerosis (MS) than are conventional MRI lesion measures. Enlargement of the third ventricle shows a particularly strong correlation impairment, suggesting clinical relevance damage to surrounding structures, such as thalamus. Previous imaging and pathology demonstrated thalamic involvement MS. In this study, we tested hypothesis volume lower MS normal subjects, correlates...
<h3>BACKGROUND/AIMS</h3> Microtropia is believed to be a static condition, in which accepted achievable levels of vision are those 6/12–6/9 maximum, with the inability achieve "normal" stereopsis. The aim this paper was present results treatment 30 consecutively presenting primary microtropes, and assess their outcomes using more active strategy than that conventionally used. <h3>METHODS</h3> Visual acuity, stereoacuity, fixation, presence central suppression scotoma were assessed all...
The goal of the study was to examine volume selected brain regions in a group mildly impaired patients with Alzheimer's disease (AD). Five were for analysis, all which have been reported show substantial change majority AD at some time course disease.Case-control experimenter "blinded."Hospital-based magnetic resonance imaging center.Fifteen subjects, eight diagnosis probable dementia Alzheimer type made concordance National Institute Neurological and Communicative Diseases...
Since Alzheimer disease (AD) neuropathology is thought to develop years before dementia, it may be possible detect subtle AD-related atrophy in preclinical AD. Here we hypothesized that the "disease signature" of cortical thinning, previously identified patients with mild AD would useful as a biomarker anatomic abnormalities consistent cognitively normal (CN) adults who dementia after longitudinal follow-up.We studied 2 independent samples were CN when scanned. In sample 1, 8 individuals...
The Alzheimer's Disease Neuroimaging Initiative (ADNI) three-dimensional T1-weighted magnetic resonance imaging (MRI) acquisitions provide a rich data set for developing and testing analysis techniques extracting structural endpoints. To promote greater rigor in meaningful comparison of different algorithms, the ADNI MRI Core has created standardized sets comprising scans that met minimum quality control requirements. We encourage researchers to test report their against these data. Standard...
Abstract Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core ADNI has been to improve methods for clinical trials disease (AD) and related disorders. Methods We review contributions MRI from present past cycles (ADNI‐1, ‐Grand Opportunity ‐2). also plans future‐ADNI‐3. Results Contributions include creating standardized acquisition protocols quality control methods; examining effect...
Advances in molecular positron emission tomography (PET) have enabled anatomic tracking of brain pathology longitudinal studies normal aging and dementia, including assessment the central model Alzheimer's disease (AD) pathogenesis, according to which TAU begins focally but expands catastrophically under influence amyloid-β (Aβ) mediate neurodegeneration cognitive decline. Initial deposition occurs many years before Aβ a specific area medial temporal lobe. Building on recent work that focus...
Although cognitive decline has been well established as a consequence of aging in non-human primate models, the prevalence or frequency impairment for specific age ranges not described. The first aim this study was to estimate on each six tests performance by comparing early-aged (19–23 years old), advanced-aged (24–28 yeras and oldest-aged (29+ old) monkeys that young adults (<15 old). second derive single overall measure help classify behavioral function our aged monkeys. Accordingly, we...
The ε4 allele of the apolipoprotein E (APOE) gene is major genetic risk factor for Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate phenotype. Carriers have been reported to greater medial temporal lobe (MTL) pathology and poorer memory than noncarriers. Less attention focused on whether there are domains cognition neuroanatomical regions more affected in Further, a potential confound prior vivo studies possibility different rates clinical misdiagnosis...
<h3>Objective</h3> To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline dementia. <h3>Design</h3> Subjects were recruited into this prospective cohort study followed for incident mean (SD) 6.0 (4.1) years. Magnetic dual-echo sequences, obtained at baseline, used to volume WMH brain parenchymal fraction (BPF), proportion intracranial cavity occupied by brain....
To examine alterations in brain activation associated with pharmacologically induced memory impairment, we used functional MRI (fMRI) to study the effects of lorazepam and scopolamine on a face–name associative encoding paradigm. Ten healthy young subjects were scanned four occasions, 2 weeks apart; they administered i.v. saline during two placebo-scanning sessions then alternately (1 mg) or (0.4 double-blind, randomized, cross-over design. Both extent magnitude within anatomic regions...
There is much debate over the role of temporal lobe structures in ability to learn and retain new information. To further assess contributions hippocampal formation (HF), five rhesus monkeys received stereotactically placed ibotenic acid lesions this region without involvement surrounding ventromedial cortices. After surgery, animals were trained on two recognition memory tasks: Delayed Non-Match Sample (DNMS) task, which tests remember specific trial unique stimuli, Recognition Span Task...
Background and Purpose— White-matter hyperintensities (WMHs) detected by magnetic resonance imaging are thought to represent the effects of cerebral small-vessel disease neurodegenerative changes. We sought determine whether spatial distribution WMHs discriminates between different groups healthy aging individuals these distributions related local perfusion patterns. Methods— examined pattern T2/fluid-attenuated inversion recovery–weighted in 3 subjects: amyloid angiopathy (n=32), Alzheimer...
Abstract Background An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of hippocampus on MR. The aim this study is to concurrent validity HarP toward local protocols, and its major sources variance. Methods Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T 3T following qualified based through standard web‐platform resegmented HarP. five most accurate followed segment 15 ADNI acquired three...