Peter Hardy
A5030368115- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Sports injuries and prevention
- Neurological disorders and treatments
- Dialysis and Renal Disease Management
- Knee injuries and reconstruction techniques
- Parkinson's Disease Mechanisms and Treatments
- Osteoarthritis Treatment and Mechanisms
- Neurological Disease Mechanisms and Treatments
- Electrical and Bioimpedance Tomography
- Lower Extremity Biomechanics and Pathologies
- Membrane-based Ion Separation Techniques
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Radiology practices and education
- MRI in cancer diagnosis
- NMR spectroscopy and applications
- Memory and Neural Mechanisms
- Advanced NMR Techniques and Applications
- Wave and Wind Energy Systems
- Cardiac Imaging and Diagnostics
- Lattice Boltzmann Simulation Studies
University of Kentucky
2016-2025
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
University of Oklahoma Health Sciences Center
2024
Cohort (United Kingdom)
2023
Royal Adelaide Hospital
2021
Albert B. Chandler Hospital
2007-2019
The University of Adelaide
2016-2018
Indiana University School of Medicine
2003-2017
Indiana University
2017
Abstract Alzheimer’s Disease (AD) is a progressive neurodegenerative disease where biomarkers for based on pathophysiology may be able to provide objective measures diagnosis and staging. Neuroimaging scans acquired from MRI metabolism images obtained by FDG-PET in-vivo measurements of structure function (glucose metabolism) in living brain. It hypothesized that combining multiple different image modalities providing complementary information could help improve early AD. In this paper, we...
The ε4 allele of the apolipoprotein E (APOE) gene is major genetic risk factor for Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate phenotype. Carriers have been reported to greater medial temporal lobe (MTL) pathology and poorer memory than noncarriers. Less attention focused on whether there are domains cognition neuroanatomical regions more affected in Further, a potential confound prior vivo studies possibility different rates clinical misdiagnosis...
Regions of the temporal and parietal lobes are particularly damaged in Alzheimer's disease (AD), this leads to a predictable pattern brain atrophy. In vivo quantification subregional atrophy, such as changes cortical thickness or structure volume, could lead improved diagnosis better assessment neuroprotective effects therapy. Toward end, we have developed fast robust method for accurately quantifying cerebral structural several subcortical regions using serial MRI scans. 169 healthy...
Abstract Fast spin‐echo (FSE) sequences are becoming popular for T2‐weighted clinical imaging because they result in a severalfold reduction time and provide conventional contrast most tissues. Fat, however, has been observed to have anomalously high signal intensity on FSE images. The present study shows that the brighter fat results from multiple 180° refocusing pulses, which eliminate diffusion‐mediated susceptibility dephasing suppress J‐coupling modulation of echo train.
Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer's disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional structural connections between brain regions as well the shape cortical regions. However, 'shape connections' are rarely investigated -e.g., how morphological attributes such thickness sulcal depth a specific region change in relation other To fill this gap, we unprecedentedly design multiplexes late...
Individuals who have had an anterior cruciate ligament (ACL) tear and reconstruction continue to experience substantial knee extensor strength loss despite months of physical therapy. Identification the alterations in muscle morphology cellular composition are needed understand potential mechanisms loss, initially as result injury subsequently from surgery rehabilitation.We performed diffusion tensor imaging-magnetic resonance imaging analyzed biopsies vastus lateralis both affected...
Loss-of-function mutations in the genes associated with primary microcephaly (MCPH) reduce human brain size by about two-thirds, without producing gross abnormalities organization or physiology and leaving other organs largely unaffected [Woods CG, et al. (2005) Am J Hum Genet 76:717-728]. There is also evidence suggesting that MCPH have evolved rapidly primates humans been subjected to selection recent evolution [Vallender EJ, (2008) Trends Neurosci 31:637-644]. Here, we show common...
Magnetic resonance (MR) imaging with a whole-body imager was performed in 10 fresh, unfixed whole human brains selected randomly from cadavers. All subjects were neurologically intact before death. T2 time constants measured within the caudate nucleus, putamen, globus pallidus, cortical gray matter, subcortical white and optic radiation. These regions then excised, values again 1.5-T MR spectrometer. Quantitative assays of iron, ferritin, protein these areas performed. Iron concentration...
Abstract The Clusterin ( CLU ) gene, also known as apolipoprotein J ApoJ ), is currently the third most associated late-onset Alzheimer’s disease (LOAD) risk gene. However, little was about possible effect of genetic variants on AD pathology in brain. Here, we evaluated interaction between 7 SNPs (covering 95% variations) and role β-amyloid (Aβ) deposition, AD-related structure atrophy, abnormal glucose metabolism neuroimaging CSF markers to clarify approach by that impacts AD. Finally, four...
Accurate prediction of Alzheimer's disease (AD) is important for the early diagnosis and treatment this condition. Mild cognitive impairment (MCI) an stage AD. Therefore, patients with MCI who are at high risk fully developing AD should be identified to accurately predict However, relationship between brain images difficult construct because complex characteristics neuroimaging data. To address problem, we present a longitudinal measurement hierarchical classification method prediction....
Neuroimaging genetics is an emerging field that aims to identify the associations between genetic variants (e.g., single nucleotide polymorphisms (SNPs)) and quantitative traits (QTs) such as brain imaging phenotypes. In recent studies, in order detect complex multi-SNP-multi-QT associations, bi-multivariate techniques various structured sparse canonical correlation analysis (SCCA) algorithms have been proposed used studies. However, markers QTs identified by existing methods may not be all...
Polygenic effects have been proposed to account for some disease phenotypes; these are calculated as a polygenic risk score (PRS). This is correlated with Alzheimer's (AD)-related phenotypes, such biomarker abnormalities and brain atrophy, associated conversion from mild cognitive impairment (MCI) AD. However, the AD PRS has examined mainly in Europeans, owing differences genetic structure lifestyle, it unclear whether same relationships between AD-related phenotypes exist non-European...
To estimate the relationship between R2 = 1/T2 as measured with a double echo spin sequence and total iron concentration in gray matter structures brains of aging rhesus monkeys.Using 1.5-T magnetic resonance (MR) imager, we collected images 12 female monkeys aged 9 23 years. From images, transverse relaxation rate was calculated selected regions. After animals were euthanized, their excised tissue punches taken substantia nigra, globus pallidus, regions cerebellum. Some assayed for using...
Abstract Background Despite best practice, quadriceps strength deficits often persist for years after anterior cruciate ligament reconstruction. Blood flow restriction training (BFRT) is a possible new intervention that applies pressurized cuff to the proximal thigh partially occludes blood as patient exercises, which enables patients train at reduced loads. This believed result in same benefits if were under high Objective The objective evaluate effect of BFRT on and knee biomechanics...
ABSTRACT Background Blood flow restriction training (BFRT) is a popular rehabilitation intervention after anterior cruciate ligament reconstruction (ACLR). However, there are lack of clinical trials establishing the efficacy using BFRT during to improve quadriceps muscle function. Purpose The purpose this study evaluate blood strength, morphology, and physiology, knee biomechanics in individuals ACLR double-blind, randomized, placebo-controlled trial (NCT03364647). Methods Forty-eight...