A5045997670- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Alzheimer's disease research and treatments
- Nutrition and Health in Aging
- Functional Brain Connectivity Studies
- Geriatric Care and Nursing Homes
- Chronic Disease Management Strategies
- Clinical practice guidelines implementation
- Health, Medicine and Society
- Palliative Care and End-of-Life Issues
- Aging, Elder Care, and Social Issues
- Health disparities and outcomes
- Healthcare Systems and Practices
- Primary Care and Health Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
- Aging and Gerontology Research
- Balance, Gait, and Falls Prevention
- Genetic Associations and Epidemiology
- Health Policy Implementation Science
- Cardiac, Anesthesia and Surgical Outcomes
- Parkinson's Disease Mechanisms and Treatments
McGill University Health Centre
2008-2025
McGill University
2015-2024
Jewish General Hospital
2015-2024
San Francisco VA Medical Center
2024
University of California, San Francisco
2024
Cohort (United Kingdom)
2023
Ottawa Hospital
2010-2018
Ottawa Hospital Research Institute
2018
Vancouver Coastal Health
2016
University of British Columbia
2016
Clinicians and researchers have shown increasing interest in frailty. Yet, there is still considerable uncertainty regarding the concept its definition. In this article, we present perspectives on key issues controversies discussed by scientists from 13 different countries, representing a diverse range of disciplines, at 2006 Second International Working Meeting Frailty Aging. The following fundamental questions are discussed: What distinction, if any, between frailty aging? relationship...
There is no consensus regarding the definition of frailty for clinical uses.A modified Delphi process was used to attempt achieve definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire developed sent experts in area frailty. Responses comments analyzed using a pre-established strategy. Statements with an agreement more than or equal 80% accepted.Overall, 44% statements concept 18% diagnostic criteria accepted. on value screening about...
Background. Frailty and fitness are important attributes of older persons, but population samples their prevalence, attributes, outcomes limited. Methods. The authors report data from the community-dwelling sample (n = 9008) Canadian Study Health Aging, a representative, 5-year prospective cohort study. Fitness frailty were determined by self-reported exercise function level testing cognition. Results. Among elderly population, 171 per 1000 very fit 12 frail. increased with age, so that age...
Background— Cardiac surgery risk scores perform poorly in elderly patients, part because they do not take into account frailty and disability which are critical determinants of health status with advanced age. There is an unmet need to combine established cardiac measures provide a more complete model for prediction patients undergoing surgery. Methods Results— This was prospective, multicenter cohort study (≥70 years) coronary artery bypass and/or valve the United States Canada. Four...
A recent paper by Bialystok et al in Neuropsychologia (vol. 45, pgs. 459 to 464) suggested that early bilingualism produced a statistically significant 4.1-year delay onset of memory loss symptoms older individuals with Alzheimer disease, possibly reflecting an increase the cognitive reserve these individuals. That study focused on multilingual elderly patients whom 90% were immigrants. Our clinic, Montreal Canada, has advantage having large set who are either immigrants or nonimmigrants but...
Frailty has long been an important concept in the practice of geriatric medicine and gerontological research, but integration implementation frailty concepts into clinical United States slow. The National Institute on Aging (NIA) Intramural Research Program Johns Hopkins Older Americans Independence Center sponsored a symposium to identify potential barriers that impede movement highlight opportunities facilitate further practice. Primary subspecialty care providers, investigators working...
Abstract Background. Care for elderly persons with disabilities is usually characterized by fragmentation, often leading to more intrusive and expensive forms of care such as hospitalization institutionalization. There has been increasing interest in the ability integrated models improve health, satisfaction, service utilization outcomes. Methods. A program vulnerable community-dwelling (SIPA [French acronym System Integrated Older Persons]) was compared usual a randomized control trial....
Abstract Background The OECD countries have recently promoted policies of deinstitutionalisation and community‐based care for the elderly. These respond to common cost pressures associated with population aging, challenge providing improved They aim substitute less costly services institutional ones, improve patient satisfaction decrease expenses. However, views concerning their success are mixed. We took a comparative cross‐national approach examine evidence, identify features an effective...
The ε4 allele of the apolipoprotein E (APOE) gene is major genetic risk factor for Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate phenotype. Carriers have been reported to greater medial temporal lobe (MTL) pathology and poorer memory than noncarriers. Less attention focused on whether there are domains cognition neuroanatomical regions more affected in Further, a potential confound prior vivo studies possibility different rates clinical misdiagnosis...
Objectives: Randomised controlled trials that directly compare cholinesterase inhibitors for the treatment of Alzheimer's disease have been characterised by significant methodological limitations. As a consequence, they failed to establish whether there are differences between agents in this class. To help address question, double-blind, randomised, controlled, multicentre trial was designed evaluate efficacy and tolerability inhibitor patients with moderate moderately-severe over 2-year...
<h3>Context</h3> The importance of early identification dementia has prompted numerous investigations mild cognitive impairment and the preclinical stages progressive degenerative disorders. To date, there is limited information from large-scale studies regarding outcomes persons specifically identified with but no (CIND). <h3>Objectives</h3> investigate for (NCI) or CIND, focusing on its etiologic subcategories, Canadian Study Health Aging (CSHA) to examine predictive validity a set core...
Cognition and mobility in older adults are closely associated they decline together with aging. Studies evaluating associations between cognitive factors gait performance people Mild Cognitive Impairment (MCI) scarce. In this study, our aim was to determine whether specific have a more identifiable effect on velocity during dual-tasking MCI.Fifty-five participants, mean age 77.7 (SD = 5.9), 45% women, MCI were evaluated for global cognition, working memory, executive function, attention....
Background: frailty, a multi-dimensional geriatric syndrome, confers high risk for falls, disability, hospitalisation and mortality. The prevalence correlates of frailty in the UK are unknown. Methods: defined by Fried, was examined among community-dwelling young-old (64–74 years) men (n = 320) women 318) who participated Hertfordshire Cohort Study, UK. Results: 8.5% 4.1% (P 0.02). Among men, older age 0.009), younger leaving education 0.05), not owning/mortgaging one's home (odds ratio [OR]...
We studied the efficacy and safety of oral tetrahydroaminoacridine (THA) combined with lecithin in 52 patients Alzheimer's disease. The maximal tolerated dose THA (up to 100 mg per day) was determined during an eight-week titration period, after which or placebo given two sequential randomized periods treatment lasting eight weeks each. Highly purified (4.7 g administered all phases study. Efficacy expressed terms scores on Mini—Mental State (MMS) test, modified MMS Hierarchic Dementia...
The frequency, nature, context, and caregivers' reactions to aggressive behavior in 213 dementia patients residing the community was studied. Aggression reported 57.2% of 10.6% caregivers. Predictors patient aggression were greater frequency memory problems, premorbid aggression, a more troubled social relationship between caregiver. Patient predicted decision discontinue home care.