A5077386817- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Fish Ecology and Management Studies
- Aquaculture disease management and microbiota
- Myxozoan Parasites in Aquatic Species
- Plant Molecular Biology Research
- Bioinformatics and Genomic Networks
- Medical Imaging Techniques and Applications
- Biomedical and Engineering Education
- Functional Brain Connectivity Studies
- Genetics, Bioinformatics, and Biomedical Research
- Surfactants and Colloidal Systems
- Photosynthetic Processes and Mechanisms
- Diet and metabolism studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Associations and Epidemiology
- Parasite Biology and Host Interactions
- Brain Tumor Detection and Classification
- Identification and Quantification in Food
- Aquatic Invertebrate Ecology and Behavior
- Plant Stress Responses and Tolerance
- Polysaccharides and Plant Cell Walls
- Health, Environment, Cognitive Aging
- Ethics in Clinical Research
- Water Quality and Resources Studies
Bradley University
2005-2025
Brigham and Women's Hospital
1990-2024
Massachusetts General Hospital
2022-2024
Harvard University
1988-2024
University of California, San Francisco
2024
Gordon Center for Medical Imaging
2024
San Francisco VA Medical Center
2024
Willamette University
2018
State Street (United States)
2018
Arizona State University
2017
The frequency ( frq ) locus of Neurospora crassa was originally identified in searches for loci encoding components the circadian clock. gene is now shown to encode a central component molecular feedback loop which product negatively regulated its own transcript, resulted daily oscillation amount transcript. Rhythmic messenger RNA expression essential overt rhythmicity organism and no constitutive rescued normal loss-of-function mutants. Step reductions FRQ-encoding transcript set clock...
The ε4 allele of the apolipoprotein E (APOE) gene is major genetic risk factor for Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate phenotype. Carriers have been reported to greater medial temporal lobe (MTL) pathology and poorer memory than noncarriers. Less attention focused on whether there are domains cognition neuroanatomical regions more affected in Further, a potential confound prior vivo studies possibility different rates clinical misdiagnosis...
The frequency (frq) locus encodes a key component, state variable, in cellular oscillator generating circadian rhythmicity. Two transcripts have been mapped to this region, and data presented here are consistent with the existence of third transcript. Analysis cDNA clones clock mutants from region focuses attention on one transcript encoding protein. FRQ, which is central component: (i) mutations all semidominant frq alleles result single amino acid substitutions map open reading frame (ORF)...
Abstract Changes in intracellular calcium (Ca2+) levels serve to signal responses diverse stimuli. Ca2+ signals are likely perceived through proteins that bind Ca2+, undergo conformation changes following binding, and interact with target proteins. The 50-member calmodulin-like (CML) Arabidopsis (Arabidopsis thaliana) family encodes containing the predicted Ca2+-binding EF-hand motif. functions of virtually all these unknown. CML24, also known as TCH2, shares over 40% amino acid sequence...
The aim of this study was to examine the molecular basis for multiple antibiotic and mercury resistance in Canadian isolates Aeromonas salmonicida subsp. salmonicida. Phenotypic genotypic methods were employed identify plasmid-associated genes determine organization those multidrug-resistant (MDR) A. isolates. MDR phenotype transferable via conjugation using Escherichia coli, hydrophila Edwardseilla tarda as recipients. Antibiotic carried by a conjugative IncA/C plasmid. Three distinct...
Abstract INTRODUCTION Tau‐positron emission tomography (PET) outcome data of patients with Alzheimer's disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instrumentation, and methods analysis. METHODS Using head‐to‐head from five cohorts tau PET radiotracers designed target deposition AD, we tested a joint propagation model (JPM) harmonize quantification (units termed “CenTauR” [CTR]). JPM is statistical...
Methods to control the development of toxic by-products in water were evaluated for various pet-fish species enclosed polyethylene bags overlayed with oxygen. A formula three components was developed that decreased concentration ammonia and carbon dioxide, controlled bacterial growth, maintained a higher pH compared untreated controls held under similar conditions. Clinoptilolite at 14 g/liter accumulation, tris buffer (0.017 M) 8.0 accumulation free CO2, neomycin sulfate 20 mg/liter...
Plants exposed to repetitive touch or wind are generally shorter and stockier than sheltered plants. These mechanostimulus-induced developmental changes termed thigmomorphogenesis may confer resistance subsequent stresses. An early response of Arabidopsis thaliana is the up-regulation TCH (touch) gene expression. The signal transduction pathway that leads mechanostimulus responses not well defined. A role for ethylene has been proposed based on observation mechanostimulation plants evolution...
• To determine whether abnormalities in regional cerebral functional activity estimated by iofetamine hydrochloride I 123 and single photon emission computed tomography can be detected mild or moderate as well severe cases of Alzheimer's disease (AD), we performed 123-single 37 patients with probable AD (nine mild, 18 moderate, ten dementia) nine age-matched control subjects. lofetamine uptake was measured right left frontal, temporal, parietal, occipital cortices. Mean (right left) lowest...
To determine the diagnostic accuracy of iofetamine hydrochloride I 123 (IMP) with single photon emission computed tomography in Alzheimer's disease, we studied 58 patients AD and 15 age-matched healthy control subjects. We used a qualitative method to assess regional IMP uptake entire brain rate image data sets as normal or abnormal without knowledge subjects'clinical classification. The sensitivity specificity were 88% 87%, respectively. In mild cognitive deficits (Blessed Dementia Scale...
The Arabidopsis TCH genes were discovered as a consequence of their marked upregulation expression in response to seemingly innocuous stimuli, such touch. Further analyses have indicated that these are upregulated by variety diverse stimuli. Understanding the mechanism(s) and factors control gene regulation will shed light on signalling pathways enable plants respond changing environmental conditions. proteins include calmodulin, calmodulin‐related xyloglucan endotransglycosylase. Expression...
Abstract A quantitative polymerase chain reaction (QPCR) assay has been developed to detect varying levels of Renibacterium salmoninarum , the causative agent bacterial kidney disease. This allows for direct enumeration DNA or RNA copy number within tissues and body fluids. The can be applied non‐lethally used determine whether R. is transcriptionally active. presence in from 430 chinook salmon collected five Idaho Fish Game operated hatcheries was initially evaluated using widely employed...
To investigate whether intraindividual variability (IIV) in reaction time (RT) over monthly administered cognitive tasks is increased cognitively unimpaired older adults who are at risk for decline, and this independent of mean RT performance.
Abstract A stock of rainbow trout, Oncorhynchus mykiss , held at an experimental facility, was found to be heavily infested with the lernmaeapodid copepod Salmincola californiensis . The efficacy and effects treatment were compared ivermectin or manual removal parasites as a means control S. One group fish orally intubated 0.2 mg active ingredient kg −1 fish. second administered after further 14 days. In fish, manually removed from gills using forceps. These sampled for up 21 days post‐first...
In this study, susceptibility and potential carrier status of burbot, Lota lota, were assessed for five important fish pathogens. Burbot demonstrated elevated mortality following challenge with infectious haematopoietic necrosis virus (IHNV) by immersion to Aeromonas salmonicida intraperitoneal (i.p.) injection. IHNV persisted in at least 28 days, whereas A. was not re-isolated beyond 17 days post-challenge. contrast, burbot appeared refractory Flavobacterium psychrophilum intramuscular...
Abstract From the mid‐1980s through early 1990s, outbreaks of bacterial kidney disease (BKD) caused by Renibacterium salmoninarum continued in Chinook salmon Oncorhynchus tshawytscha Idaho Department Fish and Game (IDFG) hatcheries despite use three control methods: (1) injection returning adult fish with erythromycin to reduce prespawning BKD mortality limit vertical transmission R. , (2) topical disinfection green eggs iodophor, (3) prophylactic treatments juvenile erythromycin‐medicated...
A new species of Myxosporea, Myxobolus neurotropus n. sp., is described from the brain and spinal cord rainbow trout (Oncorhynchus mykiss) Duncan Creek, Owyhee County, Idaho. Spores are oval, have 2 pyriform polar capsules, possess a thick spore wall (sutural rim) with short intracapsular offshoot. The mean dimensions length 11.8 μm, width 10.8 thickness 8.8 μm. This myxozoan compared to other found in cranial tissues salmonids terms morphology phylogenetic analysis. Because it cord,...
Abstract Background Tau‐PET imaging allows in‐vivo detection of neurofibrillary tangles. One tau‐PET tracer (i.e., [ 18 F]flortaucipir) has received FDA‐approval for clinical use, and multiple other tracers have been implemented into trials participant selection and/or as a primary or secondary outcome measure. To optimize future use tau‐PET, it is essential to understand how demographic, genetic factors affect tau‐PET‐positivity rates. Method This large‐scale multi‐center study includes...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDiffusion of charged micelles through microporous membranesKeith A. Johnson, G. B. Westermann-Clark, and D. O. ShahCite this: Langmuir 1989, 5, 4, 932–938Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/la00088a009https://doi.org/10.1021/la00088a009research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations16LEARN ABOUT...