A5103091538- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Lanthanide and Transition Metal Complexes
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Statistical Methods in Clinical Trials
- Diet and metabolism studies
- Neurological Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Adipose Tissue and Metabolism
- Cardiac Imaging and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Cognitive Abilities and Testing
- Cerebrovascular and Carotid Artery Diseases
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Mitochondrial Function and Pathology
- Aging and Gerontology Research
- Cholinesterase and Neurodegenerative Diseases
- S100 Proteins and Annexins
Amsterdam Neuroscience
2016-2025
Vrije Universiteit Amsterdam
2020-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017-2025
Amsterdam University Medical Centers
2021-2024
Lund University
2021-2024
University Medical Center
2021
University College London
2021
Neurology, Inc
2017
University Medical Center Utrecht
2017
Cognitive reserve (CR) explains interindividual differences in the ability to maintain cognitive function presence of neuropathology. We developed a neuroimaging approach including measure brain atrophy and cognition capture this construct. In group 511 Alzheimer's disease (AD) biomarker-positive subjects different stages across spectrum, we performed 3T magnetic resonance imaging predicted gray matter (GM) volume each voxel based on performance (i.e. global composite score), adjusted for...
Survival estimates for individuals with Alzheimer disease (AD) are informative to understand the trajectory, but precise atypical AD variants scarce. Atypical characterized by nonamnestic phenotypes, an early onset, and lower prevalence of APOEε4 carriership, which affect trajectory. We aimed provide survival posterior cortical atrophy (PCA), logopenic variant primary progressive aphasia (lvPPA), behavioral (bvAD) evaluate effect these diagnoses beyond known mortality determinants. From...
To assess the [18F]flortaucipir binding distribution across MAPT mutations in presymptomatic and symptomatic carriers.We compared regional potential (BPND) derived from a 130-minute dynamic PET scan 9 (pre)symptomatic mutation carriers (4 with P301L [1 symptomatic], 2 R406W 1 L315R, S320F, G272V carrier) 30 cognitively normal controls 52 patients Alzheimer disease.[18F]Flortaucipir BPND images showed overall highest carriers. This was most pronounced carrier whom tau exceeded control range...
Accumulation of amyloid beta can be visualized using [ 18 F]florbetapir positron emission tomography. The aim this study was to identify the optimal model for quantifying uptake and assess test–retest reliability corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 3) eight controls 63 4 MMSE: 30 0) were included. Ninety-minute dynamic tomography scans, together with arterial blood sampling, acquired immediately...
Abstract Background Tau‐PET imaging allows in‐vivo detection of neurofibrillary tangles. One tau‐PET tracer (i.e., [ 18 F]flortaucipir) has received FDA‐approval for clinical use, and multiple other tracers have been implemented into trials participant selection and/or as a primary or secondary outcome measure. To optimize future use tau‐PET, it is essential to understand how demographic, genetic factors affect tau‐PET‐positivity rates. Method This large‐scale multi‐center study includes...
A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack decline is phenocopy (phFTD). Growing evidence suggests that psychological, psychiatric environmental factors underlie phFTD. We describe patient diagnosed prior to the revision diagnostic guidelines FTD. Repeated was normal there no FTD pathology at autopsy, rejecting diagnosis. hypothesize on etiological hindsight might have played role. This case report contributes understanding phFTD...
ABSTRACT Background Survival estimates for individuals with Alzheimer’s disease (AD) are informative to understand the full trajectory, but precise atypical AD variants scarce. Atypical characterized by non-amnestic phenotypes, an early-onset and lower prevalence of APOE ε 4 -carriership, which all possible modulators clinical trajectories. We aimed provide survival posterior cortical atrophy (PCA; “visual-AD”), logopenic variant primary progressive aphasia (lvPPA; “language-AD”)...
Abstract Background There is a strong link between tau and progression of Alzheimer’s disease (AD), necessitating an understanding spreading mechanisms. Prior research, predominantly in typical AD, suggested that propagates from epicenters (regions with earliest tau) to functionally connected regions. However, given the constrained spatial heterogeneity validating this connectivity‐based model AD variants distinct deposition patterns crucial. Method We included 269 amyloid‐β‐positive...
Abstract Background Survival estimates for individuals with Alzheimer’s disease (AD) are informative to understand the full trajectory. A previous meta‐analysis estimated mean survival of AD patients at 5.8 years from diagnosis, but precise atypical variants scarce. Atypical characterized by a non‐amnestic phenotype, relatively early‐onset and lower prevalence APOE4, which all possible modulators clinical trajectories. Here we aimed evaluate how phenotypical atypicality affects mortality...
This single case study examines selective Pittsburgh compound-B (PiB) binding to an intracerebral light-chain amyloidoma using a 90-minute dynamic [11C]PiB-PET scan and brain biopsy tissue. Parametric non-displaceable potential (BPND) images showed low specific in the (BPND = 0.23), while relative tracer delivery was adequate (R1 0.44). Histology of tissue revealed strong coloring with Congo-red, thioflavin-S, X-34, indicating presence amyloid. However, immunological staining 6F/3D absence...
Abstract Background Neuropsychiatric symptoms (NPS) constitute a pervasive component of Alzheimer’s disease (AD) for patients with “typical” (i.e. amnestic‐predominant) phenotype. The prevalence and course NPS is largely unknown in atypical variants AD the few conducted studies are clouded by inclusion Aβ‐negative individuals. Understanding evolution crucial adequate patient care individuals these rare early‐onset phenotypes. Methods We included 632 amyloid‐β‐positive subjects from Amsterdam...
The tau tracer [18F]AV-1451 is a promising ligand for imaging tauopathies such as Alzheimer’s disease (AD). Increased uptake of in AD patients compared with healthy controls (HC) has been shown, strong correlation between and cognitive decline. These studies quantified load using the standardized value ratio (SUVr) derived from static scan (80-100 min post injection). SUVr may, however, be flow dependent and, especially longitudinal studies, should validated against fully quantitative...
The tau tracer [18F]AV-1451 is a promising ligand for imaging tauopathies such as Alzheimer's disease (AD). Increased uptake of in AD patients compared with healthy controls (HC) has been shown, strong correlation between and cognitive decline. These studies quantified load using the standardized value ratio (SUVr) derived from static scan (80-100 min. post injection). SUVr may, however, be flow dependent and, especially longitudinal studies, should validated against fully quantitative...
Former studies evaluating the diagnostic impact of amyloid PET utilized selected research samples. We performed in an unselected memory cohort and assessed its on diagnosis, confidence diagnosis patient management, taking into account patients’ experiences. As part ABIDE (Alzheimer biomarkers daily practice: EudraCT: 2014–000562–21) project, we offered [18F]florbetaben to all patients visiting our clinic during two years as their routine work-up. For each patient, a pre- post-amyloid was...
Flortaucipir ([18F]AV1451) is a promising positron emission tomography (PET) tau tracer to visualize in vivo binding Alzheimer's disease (AD). The purpose of the present study was evaluate performance several parametric methods, as well standardised uptake values ratios (SUVr), obtain quantitatively accurate images [18F]AV1451. Dynamic PET scans 130 minutes duration, including arterial sampling, were performed 5 AD patients and controls (C). Parametric generated. Plasma input based Logan...
Flortaucipir ([18F]AV1451) is a promising positron emission tomography (PET) tau tracer to visualize in vivo binding Alzheimer's disease (AD). The purpose of the present study was evaluate performance several parametric methods, as well standardised uptake values ratios (SUVr), obtain quantitatively accurate images [18F]AV1451. Dynamic PET scans 130 minutes duration, including arterial sampling, were performed 5 AD patients and controls (C). Parametric generated. Plasma input based Logan...
The increasing number of neuroimaging software applications and settings available has left researchers with the need to determine reproducibility between collaborating sites methods that optimize study effect size. Our goal was compare hippocampal values from multiple versions within SPM Freesurfer across three sites. Voxel based morphometry (VBM) performed on T1-weighted MPRAGE images at Indiana University School Medicine (IUSM) 20 cognitively normal older adults (CN) Alzheimer's (AD)...
The behavioral variant of Alzheimer's disease (bvAD) is characterized by early and predominant personality changes, with AD as primary etiology. We previously found an "AD-typical" posterior atrophy pattern in bvAD, leaving its "frontal" presentation largely unexplained. In this study, we explored alternative explanations for clinico-anatomical dissociation. included 29 patients bvAD compared them typical (memory-predominant) (tAD; n=29) patients, frontotemporal dementia (bvFTD; n=30)...
Posterior cortical atrophy (PCA) is a clinical-radiological syndrome characterized by higher-visual processing deficits and in posterior parts of the brain. We examined whether differences regional may explain clinical heterogeneity observed among PCA patients. Sixty-nine patients with positive amyloid-β biomarkers were included (Table 1). Spatial distribution was assessed using voxelwise contrasts against controls (n=72). Next, residual maps obtained performing regression analyses,...
The behavioral variant of Alzheimer's disease (bvAD) is characterized by early and predominant personality changes, with AD as primary etiology. We previously found an "AD-typical" posterior atrophy pattern in bvAD, leaving its "frontal" presentation largely unexplained. In this study, we explored alternative explanations for clinico-anatomical dissociation. included 29 patients bvAD compared them typical (memory-predominant) (tAD; n=29) patients, frontotemporal dementia (bvFTD; n=30)...