A5091662459- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- MRI in cancer diagnosis
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Brain Tumor Detection and Classification
- Acute Ischemic Stroke Management
- Mental Health Research Topics
- Psychedelics and Drug Studies
- Neural and Behavioral Psychology Studies
- Traumatic Brain Injury Research
- Medical Imaging Techniques and Applications
- Paranormal Experiences and Beliefs
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Neural Networks and Applications
- Advanced Bandit Algorithms Research
- Neuroscience and Neuropharmacology Research
- Reinforcement Learning in Robotics
- Attention Deficit Hyperactivity Disorder
- Blood Pressure and Hypertension Studies
- Neurobiology of Language and Bilingualism
University of Southern California
2022-2025
University of California, Berkeley
2019-2024
VA Northern California Health Care System
2021-2024
Southern California University for Professional Studies
2023-2024
University of Cambridge
2018-2023
University of California System
2023
Addenbrooke's Hospital
2018-2021
Imaging Center
2021
Harvard University
2019
Yahoo (United Kingdom)
2019
Prominent theories of consciousness emphasise different aspects neurobiology, such as the integration and diversity information processing within brain. Here, we combine graph theory dynamic functional connectivity to compare resting-state MRI data from awake volunteers, propofol-anaesthetised patients with disorders consciousness, in order identify consciousness-specific patterns brain function. We demonstrate that cortical networks are especially affected by loss during temporal states...
Investigating changes in brain function induced by mind-altering substances such as LSD is a powerful method for interrogating and understanding how mind interfaces with brain, connecting novel psychological phenomena their neurobiological correlates. known to increase measures of complexity, potentially reflecting correlate the especially rich phenomenological content psychedelic-induced experiences. Yet although subjective stream consciousness constant ebb flow, no studies date have...
Significance What changes in the brain when we lose consciousness? One possibility is that loss of consciousness corresponds to a transition brain’s electric activity away from edge-of-chaos criticality, or knife’s edge between stability and chaos. Recent mathematical developments have produced tools for testing this hypothesis, which apply cortical recordings diverse states. We show cortex indeed poised near boundary chaos during conscious states transitions unconsciousness disrupts...
Abstract A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals pathological pharmacologically-induced perturbations into distributed patterns structure-function dependence across scales: harmonic modes human structural connectome. We show that coupling a generalisable indicator under bi-directional neuromodulatory control. find increased scales during loss consciousness, whether due...
The brain is possibly the most complex system known to mankind, and its complexity has been called upon explain emergence of consciousness. However, defined in many ways by multiple different fields: here, we investigate measures algorithmic process both temporal topological domains, testing them on functional MRI BOLD signal data obtained from individuals undergoing various levels sedation with anaesthetic agent propofol, replicating our results two separate datasets. We demonstrate that...
Abstract INTRODUCTION Tau‐positron emission tomography (PET) outcome data of patients with Alzheimer's disease (AD) cannot currently be meaningfully compared or combined when different tracers are used due to differences in tracer properties, instrumentation, and methods analysis. METHODS Using head‐to‐head from five cohorts tau PET radiotracers designed target deposition AD, we tested a joint propagation model (JPM) harmonize quantification (units termed “CenTauR” [CTR]). JPM is statistical...
The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported both animal and human studies, which may contribute to cognitive neurodegenerative disorders. Limited data also suggest that being female be associated protective effects on function. Here we investigated age sex-dependent trajectories perfusion water exchange rate (kw) across lifespan...
Journal Article Dexamethasone Therapy for Bacterial Meningitis in Children: 2- versus 4-Day Regimen Get access George A. Syrogiannopoulos, Syrogiannopoulos Reprints or correspondence: Dr. Dept. of Pediatrics, University Patras, Medical School, 261 10 Greece. Search other works by this author on: Oxford Academic PubMed Google Scholar Athanassia N. Lourida, Lourida Maria C. Theodoridou, Theodoridou Irene G. Pappas, Pappas Babilis, Babilis John J. Economidis, Economidis Dimitrios Zoumboulakis,...
Measures of human brain functional connectivity acquired during the resting-state track critical aspects behavior. Recently, fluctuations in patterns-typically averaged across traditional analyses-have been considered for their potential neuroscientific relevance. There exists a lack research on differences between "static" measures and newly "time-varying" as they relate to Using magnetic resonance imagining (fMRI) data collected at rest, battery behavioral outside scanner, we determined...
Abstract Recent years have seen growing interest in characterizing the properties of regional brain dynamics and their relationship to other features structure function. In particular, multiple studies observed differences “timescale” over which activity fluctuates during periods quiet rest. cerebral cortex, these timescales been associated with both local circuit as well patterns inter‐regional connectivity, including extent each region exhibits widespread connectivity areas. current study,...
The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), and shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported both animal human studies, which may contribute to cognitive neurodegenerative disorders. Limited data also suggest that being female be associated protective effects on function. Here, we investigated age sex-dependent trajectories perfusion water exchange rate (kw) across lifespan...
The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported both animal and human studies, which may contribute to cognitive neurodegenerative disorders. Limited data also suggest that being female be associated protective effects on function. Here we investigated age sex-dependent trajectories perfusion water exchange rate (kw) across lifespan...
Human brains interpret external stimuli based on internal representations. One untested hypothesis is that the default-mode network (DMN), widely considered responsible for internally oriented cognition, can decode information. Here, we posit unique structural and functional fingerprint of precuneus (PCu) supports a prominent role posterior part DMN in this process. By analyzing imaging data 100 participants performing two attention-demanding tasks, found PCu functionally divided into dorsal...
Emotional events tend to be vividly remembered. While growing evidence suggests that emotions have their basis in brain-wide network interactions, it is unclear if and how these whole-brain dynamics contribute memory encoding. We combined fMRI, graph theory, text analyses, pupillometry a naturalistic context where participants recalled complex narratives own words. Across three independent datasets, emotionally arousing moments during the were associated with an integrated brain state...
Artificial neural networks constitute simplified computational models of circuits that might help understand how the biological brain solves and represents complex tasks. Previous research revealed recurrent (RNNs) with 48 hidden units show human-level performance in restless four-armed bandit tasks but differ from humans respect to task strategy employed. Here we systematically examined impact network capacity (no. units) on mechanisms performance. Computational modeling was applied...
Background Current methods to quantify blood biomarkers for Alzheimer's disease (AD) are expensive and not widely available. Objective To develop a low-cost, sensitive, accurate multiplex assay Aβ 40 , 42 p181Tau, p217Tau, NfL, GFAP in plasma serum based on available technology. Methods We used commercial antibodies GFAP, xMAP Luminex technology, developed the 5ADCSI these from serum. The utility of was tested matched cerebrospinal fluid (CSF) or cohort cognitively normal (CN: n = 35), with...
There is common consensus that data sharing accelerates science. Data enhances the utility of and promotes creation competition scientific ideas. Within Alzheimer’s disease related dementias (ADRD) community, types modalities are spread across many organizations, geographies, governance structures. The ADRD community not alone in facing these challenges, however, problem even more difficult because need to share complex biomarker from centers around world. Heavy-handed mandates have, date,...
Spatial variations in dopamine function are linked to cognition and substance use disorders but challenging characterize with current methods. Because influences blood vessel dilation, we hypothesized that hemodynamic latency, which reflects BOLD signal timing, could serve as an indirect marker of physiology. Across four datasets, found a topography latencies precisely distinguished the nucleus accumbens, dopaminergic region implicated motivation abuse, from other striatal regions. Using...
The precise mechanism of anaesthetic action on a neural level remains unclear. Recent approaches suggest that anaesthetics attenuate the complexity interactions (connectivity) however evidence insufficient. We used tools from network and information theory to show that, during propofol-induced sedation, collection brain regions displayed decreased in their connectivity patterns, especially so if they were sparsely connected. Strikingly, we found despite low strengths, these exhibited an...
Abstract A central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Departing predominant location- centric view neuroimaging, here we provide an alternative perspective on neural signatures human consciousness: one that intrinsically centered distributed network architecture structural connectome shapes functional activation across scales. We decompose cortical dynamics resting-state MRI into fundamental patterns structure-...
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Functional brain connectivity studies can provide important information changes in brain-state dynamics during general anesthesia. In adults, γ-aminobutyric acid–mediated agents disrupt integration of from local to the whole-brain scale. Beginning around 3 4 months postnatal age, anesthetics such as sevoflurane generate α-electroencephalography oscillations. previous...
Abstract The blood-brain barrier (BBB) plays a pivotal role in protecting the central nervous system (CNS), shielding it from potential harmful entities. A natural decline of BBB function with aging has been reported both animal and human studies, which may contribute to cognitive neurodegenerative disorders. Limited data also suggest that being female be associated protective effects on function. Here we investigated age sex-dependent trajectories perfusion water exchange rate (kw) across...