A5042540373- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Prosthetics and Rehabilitation Robotics
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Cardiac Imaging and Diagnostics
- Ion Channels and Receptors
- Muscle activation and electromyography studies
- Sulfur Compounds in Biology
- Sports Performance and Training
- Cardiovascular Effects of Exercise
- Modular Robots and Swarm Intelligence
- Genetic and phenotypic traits in livestock
- Electrospun Nanofibers in Biomedical Applications
- Ion channel regulation and function
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic and Hepatic Oncology Research
- Advanced Sensor and Energy Harvesting Materials
- Orthopaedic implants and arthroplasty
- Cancer Cells and Metastasis
- Neuroscience and Neural Engineering
University of Kentucky
2022-2025
Clemson University
2020-2024
Extremiti3D (United States)
2020
Defense Logistics Agency
2020
Minneapolis VA Health Care System
2020
University of Minnesota
2020
American Orthotic and Prosthetic Association
2020
Indiana University School of Medicine
2013-2016
Indiana University – Purdue University Indianapolis
2013-2016
Covance (United States)
2016
This investigation examined the mechanisms by which coronary perivascular adipose tissue (PVAT)-derived factors influence vasomotor tone and PVAT proteome in lean versus obese swine.Coronary arteries from Ossabaw swine were isolated for isometric tension studies. We found that (P=0.03) mesenteric (P=0.04) but not subcutaneous augmented contractions to KCl (20 mmol/L). Inhibition of CaV1.2 channels with nifedipine (0.1 µmol/L) or diltiazem (10 abolished this effect. Coronary increased...
ABSTRACT Background Blood flow restriction training (BFRT) is a popular rehabilitation intervention after anterior cruciate ligament reconstruction (ACLR). However, there are lack of clinical trials establishing the efficacy using BFRT during to improve quadriceps muscle function. Purpose The purpose this study evaluate blood strength, morphology, and physiology, knee biomechanics in individuals ACLR double-blind, randomized, placebo-controlled trial (NCT03364647). Methods Forty-eight...
The effects of coronary perivascular adipose tissue (PVAT) on vasomotor tone are influenced by an obese phenotype and distinct from other depots. purpose this investigation was to examine the lean PVAT end-effector mechanisms vasodilation identify potential factors involved.Hematoxylin eosin staining revealed similarities in adipocyte size between Ossabaw swine. Isometric tension studies isolated arteries swine that derived attenuated adenosine. Lean inhibited K(Ca) KV7, but not KATP...
ABSTRACT Introduction Prosthetic sockets must withstand instances of maximum loading without failure. The goal the present study is to evaluate strength at failure and mechanism for 3D-printed transtibial sockets, thermoplastic check carbon-fiber definitive laminated sockets. Materials Methods Three clinically available materials (carbon fiber, PETG thermoplastic, 3D print polylactic acid [PLA]) were used produce identically shaped In final assembly, designed use both with a pin-lock system....
Emerging evidence suggests that there are morphological and physiological changes to the vastus lateralis after an anterior cruciate ligament (ACL) tear. However, it is unclear whether these alterations limited just or more representative of widespread across thigh musculature and/or if precede reconstruction. The purpose this study was determine T1ρ relaxation time, a measure extracellular matrix organization in muscle, cross-sectional area (PCSA) for muscles quadriceps hamstrings...
Active lower-body exoskeleton devices can decrease the energy requirement of human body by providing mechanical assistance to muscles. However, they also alter gait kinematics and kinetics, it is not well understood whether such alterations are detrimental or beneficial body. In this pilot study, we investigated impact walking with an ankle device on biomechanics men while carrying a heavy load. We collected computed tomography images motion-capture data for five young, healthy who walked 5...
ABSTRACT Introduction Unlike endoskeletal connectors and prosthetic feet, sockets are not subjected to structural strength testing using internationally recognized test standards, such as International Organization for Standardization (ISO) 10328. Definitive fabricated in the traditional manner have been shown be inconsistent ability withstand loads applied by these standards. Persistent concerns regarding durability of 3D-printed a barrier clinical adoption 3D-printing technologies socket...
Abstract Objective This study examined the mechanisms by which H 2 S modulates coronary microvascular resistance and myocardial perfusion at rest in response to cardiac ischemia. Methods Experiments were conducted isolated arteries open‐chest anesthetized dogs. Results We found that substrate l ‐cysteine (1–10 mM ) did not alter tone of vitro or blood flow vivo . In contrast, intracoronary (ic) (0.1–3 increased from 0.49 ± 0.08 2.65 0.13 mL /min/g ( p < 0.001). increase was unaffected...
The stroma surrounding solid tumors contributes in complex ways to tumor progression. Cancer‐associated fibroblasts (CAFs) are the predominant cell type stroma. Previous studies have shown that actin‐binding protein palladin is highly expressed of pancreas tumors, but interpretation these results complicated by fact exists as multiple isoforms. In current study, expression and localization isoform 4 was examined normal specimens adenocarcinomas human pancreas, lung, colon, stomach samples....
The TRPV1, transient receptor potential vanilloid type 1, agonist capsaicin is considered to be beneficial for cardiovascular health because it dilates coronary arteries through an endothelial-dependent mechanism and may slow atheroma progression. However, recent reports indicate that high doses of constrict arterioles even provoke myocardial infarction. Thus far, the mechanisms by which TRPV1 activation modulates vascular tone remain poorly understood. This investigation examined whether...
Female athletes lag behind their male counterparts in recovery from anterior cruciate ligament (ACL) injury. Quadriceps muscle size and strength are crucial factors for regaining function after ACL injury, but little is known about how these metrics vary due to biological sex.
Ossabaw miniature swine were fed an excess calorie, atherogenic diet for 6, 9, or 12 months. Increased body weight, hypertension, and increased plasma cholesterol triglycerides are described in Table 1. For more detailed interpretations conclusions about the data, see our associated research study, "Biphasic alterations coronary smooth muscle Ca(2+) regulation during artery disease progression metabolic syndrome" McKenney-Drake, et al. (2016) [1].
While using a prosthesis, transtibial amputees can experience pain and discomfort brought on by large pressure gradients at the interface between residual limb prosthetic socket. Current solutions attempt to alleviate these soft homogenous liners reduce distribute pressures. This research investigates an additively manufactured metamaterial inlay with tailored mechanical response peak around limb. The uses hyperelastic behaving (US10244818) comprised of triangular pattern unit cells, 3D...
Previous studies have demonstrated a key role for voltage‐dependent K (K V ) channels in the regulation of coronary metabolic and ischemic vasodilation. However, channel subtypes responsible control blood flow not been clearly defined. This investigation examined hypothesis that 7 are present vascular smooth muscle regulate perfusion myocardium at rest during pacing‐induced increases metabolism. In anesthetized, open‐chest swine, we found intracoronary administration agonist flupirtine (1...
Abstract While using a prosthesis, transtibial amputees can experience pain and discomfort brought on by large pressure gradients, at the interface between residual limb prosthetic socket. Current solutions attempt to alleviate these gradients soft homogenous liners reduce distribute pressures. This research investigates an additively manufactured metamaterial inlay with adjustable mechanical response in order peak around limb. The uses hyperelastic behaving (US10244818) comprised of...
This investigation examined the effects of perivascular adipose tissue (PVAT) on vasodilatory mechanisms in coronary circulation. Isometric tension studies were performed isolated arteries from lean and obese Ossabaw swine. After a 30 min incubation period with 0.3 g PVAT, constricted U46619 (1 μM) or PGF2α (10 responses to H 2 O μM–1 mM) examined. Compared untreated‐control arteries, addition PVAT markedly attenuated relaxation 1 mM swine (78 ± 9% vs. 17 11%). effect was similar intact...
This study examined mechanisms by which hydrogen sulfide (H 2 S) regulates coronary blood flow. Experiments were conducted in open‐chest anesthetized dogs while perfusion pressure was held constant at 100 mmHg with a servo‐controlled roller pump. We found that intracoronary (ic) administration of H S (0.1–3 mM) increased flow from 0.49 ± 0.08 to 2.65 0.13 ml/min/g (P < 0.001). increase unaffected inhibition Kv channels 4‐aminopyridine (0.3 mM, ic) but significantly attenuated (57%) the K...