A5083744223- Hematopoietic Stem Cell Transplantation
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Ubiquitin and proteasome pathways
- Neonatal Respiratory Health Research
- Chronic Myeloid Leukemia Treatments
- Neuropeptides and Animal Physiology
- Global Cancer Incidence and Screening
- Genetics and Neurodevelopmental Disorders
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Smoking Behavior and Cessation
- IL-33, ST2, and ILC Pathways
- Autism Spectrum Disorder Research
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- Nerve injury and regeneration
- Occupational Health and Burnout
- Phytochemical compounds biological activities
Indiana University – Purdue University Indianapolis
2012-2023
Indiana University School of Medicine
2012-2023
Rett Syndrome Research Trust
2022-2023
Northeast Ohio Medical University
2022-2023
Indiana University
2015-2020
University School
2020
Boston Children's Museum
2017
Boston Children's Hospital
2017
Indiana University Health
2017
West Virginia University
2006-2012
The host's response to infection is characterized by altered levels of neurotrophins and an influx inflammatory cells sites injured tissue. Progenitor that give rise the differentiated cellular mediators inflammation are derived from bone marrow progenitor where their development regulated, in part, cues stromal (BMSC). As such, alteration BMSC function elevated systemic has potential alter biologically relevant ways, including downstream cytokine production influences hematopoietic development.
Delayed engraftment remains a limitation of umbilical cord blood (UCB) transplantation. We previously showed that inhibition dipeptidylpeptidase (DPP)-4 using sitagliptin 600 mg daily was safe with encouraging results on engraftment, but not sustained. evaluated the efficacy and feasibility higher doses to enhance UCB in patients hematological cancers. Fifteen patients, median age 41 (range, 18-59) years, received single grafts matched at 4 (n=11) or 5 (n=4) 6 HLA loci nucleated cell dose...
Rett syndrome, a rare genetic neurodevelopmental disorder in humans, does not have an effective cure. However, multiple therapies and medications exist to treat symptoms improve patients’ quality of life. As research continues discover evaluate new for syndrome patients, there remains lack objective physiological motor activity-based (physio-motor) biomarkers that enable the measurement effect these on change severity. In our work, using commercially available wearable chest patch, we...
Cancer is the leading cause of death for Hispanics in USA. Screening and prevention reduce cancer morbidity mortality.This study administered a cross-sectional web-based survey to self-identified Hispanic residents state Indiana assess their cancer-related knowledge, beliefs, behaviors, as well identify what factors might be associated with screening prevention. Chi-square Fisher's exact test were used compare associations logistic regression develop both univariate multivariate models.A...
Hematopoietic reconstitution, following bone marrow or stem cell transplantation, requires a microenvironment niche capable of supporting both immature progenitors and cells with the capacity to differentiate expand. Osteoblasts comprise one important component this niche. We determined that treatment human primary osteoblasts (HOB) melphalan VP-16 resulted in increased phospho-Smad2, consistent TGF-β1 activity. This increase was coincident reduced HOB support B lineage chemotaxis adherence....
Abstract Attendance at professional conferences is an important component of career development, because are a major forum for presenting new research, interacting with colleagues and networking. An extensive literature documents differences in the experiences women men, including conferences. We hypothesized that less likely than men to ask questions conferences, thus forgoing opportunities development. To address this issue, we analyzed question-asking behavior 2019 Annual Meeting...
Remote ischemic preconditioning (RIPC) is an adaptive response in which tolerance to prolonged periods of ischemia/reperfusion (I/R) induced a target organ by prior shorter I/R distant organ. Although this phenomenon has been established within healthy population, the effects RIPC have yet be defined obese population. The benefits coupled with type protection are particular importance since obesity, and confounding factors associated it, known result repeated events. Thus, we set forth...
Low oxygen bone marrow (BM) niches (~1%-4% low O2 ) provide critical signals for hematopoietic stem/progenitor cells (HSC/HSPCs). Our presented data are the first to investigate live, sorted HSC/HSPCs in their native conditions. Transcriptional and proteomic analysis uncovered differential Ca2+ regulation that correlated with overlapping phenotypic populations consisting of robust increases cytosolic mitochondrial , ABC transporter (ABCG2) expression sodium/hydrogen exchanger (NHE1)...
Abstract Improving understanding of behaviors that increase or reduce cancer risk for different Hispanic groups is a public health priority; such knowledge sparse in new gateway immigration locations as Indiana. The aims this study were to: 1) describe beliefs and preventive/risk reduction (physical activity, tobacco, alcohol use) among adults; 2) examine differences preventive by country/territory birth, socioeconomic status, area residence (urban vs. rural); 3) determine predictors...