A5051691320- Medical Imaging Techniques and Applications
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Radiopharmaceutical Chemistry and Applications
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Medical Image Segmentation Techniques
- Genetic Neurodegenerative Diseases
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Lanthanide and Transition Metal Complexes
- Cholinesterase and Neurodegenerative Diseases
- Motor Control and Adaptation
- Computational Drug Discovery Methods
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Pharmacological Effects and Toxicity Studies
- Radiomics and Machine Learning in Medical Imaging
- Receptor Mechanisms and Signaling
- Multiple Sclerosis Research Studies
UCB Pharma (Belgium)
2018-2024
Novartis (Switzerland)
2009-2021
Novartis Institutes for BioMedical Research
2009-2016
Novartis (United States)
2015
Pfizer (United States)
2005-2012
University Medical Center Groningen
2004-2009
University of Groningen
1999-2009
Combat Capabilities Development Command Soldier Center
2008-2009
United States Army Combat Capabilities Development Command
2008
Princess Margaret Hospital
2007
To investigate the pathophysiology of fatigue in MS, we assessed cerebral glucose metabolism (CMR-Glu) 47 MS patients using PET and 18F-fluorodeoxyglucose. Applying Fatigue Severity Scale (FSS), first compared with severe (MS-FAT, n = 19, FSS > 4.9) without (MS-NOF, 16, < 3.7) on a pixel-by-pixel basis Statistical Parametric Mapping (SPM95). Second, values all covering whole range this scale CMRGlu an analysis covariance In addition, determined global by region-of-interest analysis. Sixteen...
We used PET scans with the tracers [18F]fluorodeoxyglucose (FDG) and [11C]raclopride (RACLO) to study glucose metabolism dopamine D2 receptor binding in caudate nucleus putamen of 18 carriers Huntington's disease gene mutation (10 asymptomatic subjects eight untreated symptomatic patients an early stage). also performed MR1 measured bicaudate ratio (BCR) same subjects. Data were compared those from nine mutation-negative members families separate groups age matched controls. The repeated...
WITH the purpose of studying neural activation associated with reward processing in humans, we measured regional cerebral blood flow 10 right-handed healthy subjects performing a delayed go–no go task two different reinforcement conditions. Correct responses were either rewarded by money or simple ‘ok’ reinforcer. Behaviour money, as compared reinforcement, was most significantly dorsolateral and orbital frontal cortex also involved midbrain thalamus. These results may reflect information,...
We used PET with the tracers [18F]fluorodeoxyglucose (FDG), [18F]fluorodopa (FDOPA) and [11C]raclopride (RACLO) to study striatal glucose dopa metabolism, dopamine D2 receptor binding, respectively, in nine patients multiple system atrophy. Ten classical Parkinson's disease were investigated same three tracers' separate groups, each of 10 healthy subjects, served as control populations. found that FDOPA values separated all subjects from parkinsonism but they not useful distinguishing...
Retinal lesions caused by eye diseases such as glaucoma and age-related macular degeneration can, over time, eliminate stimulation of parts the visual cortex. This could lead to inactive cortical neuronal tissue, but this has not been established in humans. Here, we used magnetic resonance imaging assess effects prolonged sensory deprivation human High-resolution anatomical images were obtained subjects with foveal (age-related degeneration) peripheral (glaucoma) retinal well age-matched...
Abstract Introduction This randomized, double‐blind, placebo‐controlled, 90‐week study assessed safety, tolerability, and immunogenicity of CAD106 with/without adjuvant in patients with mild Alzheimer's disease. Methods One hundred twenty‐one received up to seven intramuscular injections (150 μg or 450 μg) placebo ± over 60 weeks. An amyloid positron emission tomography (PET) substudy was also conducted. Results induced strong serological responses (amyloid‐beta [Aβ]–Immunoglobuline G[IgG])...
11 C-UCB-J is a positron emission tomography (PET) radioligand that has been used in humans for synaptic vesicle glycoprotein 2A (SV2A) imaging and as potential density marker. The centrum semiovale (CS) proposed reference region noninvasive quantification of C-UCB-J, due to negligible concentrations SV2A this baboon brain assessed by vitro methods. However, displacement scans with SV2A-specific drug levetiracetam humans, decrease concentration was observed the CS, consistent some degree...
To assess the relationship between striatal dopa decarboxylase capacity, D2 dopamine receptor binding, and energy metabolism in Parkinson's disease (PD).Positron emission tomographic (PET) studies of glucose binding caudate nucleus putamen patients with PD at different Hoehn Yahr (HY) stages using PET tracers 18F-fluorodeoxyglucose (FDG), 6-18F-fluoro-L-dopa (FDOPA), 11C-raclopride (RACLO).Positron tomography research program Paul Scherrer Institute.Twenty (HY I through IV; five for each...
Glutamate mediated excitotoxicity of the hyperactive subthalamic nucleus (STN) has been reported to contribute nigral degeneration in Parkinson's disease (PD). Deep brain stimulation STN (STN DBS), its role as a highly effective treatment severe PD motor complications, thought inhibit hyperactivity and therefore decrease progression PD.In prospective two centre study, was determined by means serial (18)F-fluorodopa (F-dopa) positron emission tomography (PET) 30 patients with successful DBS...
<b><i>Background:</i></b> The authors identified the second known mutation in α<i>-synuclein</i>(<i>SNCA</i>) gene, an alanine-to-proline exchange amino acid position 30 (A30P), that cosegregates with disease one German family autosomal dominantly inherited parkinsonism (ADP). studied carriers of A30P to compare phenotype this idiopathic PD (IPD) and assess nigrostriatal dopaminergic function symptomatic preclinical carriers. <b><i>Methods:</i></b> pedigree spans five generations affected...
Abstract Dopamine is known to regulate food intake by modulating reward via the mesolimbic circuitry of brain. The objective this study was compare effects high energy input (i.v. glucose) on striatal and thalamic dopamine release in overweight lean individuals. We hypothesized that glucose would induce positive ratings (e.g., satiety) Behavioral Analog Scales, particularly food‐deprived subjects. [ 11 C]raclopride PET performed for 12 (mean BMI = 22 kg/m 2 ) 33 healthy Each subject imaged...
Context: Patients who sustain an acute spinal cord injury (SCI) experience rapid dramatic reductions in bone mineral density (BMD), especially marked sublesional areas and sometimes leading to hypercalcemia hypercalciuria, as well increased fracture risk. Objective: In this prospective, double-blind, randomized, placebo-controlled study, we evaluated the hypothesis that oral alendronate administration would preserve BMD when administered soon after SCI. Intervention: Thirty-one patients with...
Diagnosing Parkinson's disease (PD) on clinical grounds may be difficult, especially in the early stages of disease. F-DOPA PET and FP-CIT SPECT scans are able to determine presynaptic dopaminergic activity different ways. The aim this study was compare sensitivity specificity two methods detection striatal deficits same cohort PD patients healthy controls.Movement disorder specialists recruited 11 with early-stage 17 advanced PD. underwent both an scan scan. In addition, 10 or were...
[ 11 C]P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT 1B ) receptors with positron emission tomography (PET). The purpose of this study was evaluate for application in humans, determine the most suitable quantification method. Positron data arterial input function measurements were acquired cohort 32 human subjects. Using functions, compartmental modeling, Logan graphical analysis, multilinear method MA1 tested. Both two...
Regulatory qualification of a biomarker for defined context use provides scientifically robust assurances to sponsors and regulators that accelerate appropriate adoption biomarkers into drug development.The Coalition Against Major Diseases submitted dossier the Scientific Advice Working Party European Medicines Agency requesting opinion on hippocampal volume as enriching clinical trials in subjects with mild cognitive impairment, incorporating scientific rationale, literature review de novo...