A5033147621- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Long-Term Effects of COVID-19
- Dementia and Cognitive Impairment Research
- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ultrasound Imaging and Elastography
- Functional Brain Connectivity Studies
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Ultrasound and Hyperthermia Applications
- Cerebral Venous Sinus Thrombosis
- Advanced MRI Techniques and Applications
- Effects of Vibration on Health
- Alzheimer's disease research and treatments
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neural and Behavioral Psychology Studies
- Cerebral Palsy and Movement Disorders
University at Buffalo, State University of New York
2016-2025
Jacobs (United States)
2016-2025
Inserm
2021-2024
Jacobs Institute
2012-2024
The University of Sydney
2013-2024
Palacký University Olomouc
2024
The University of Western Australia
2024
Düsseldorf University Hospital
2024
Heinrich Heine University Düsseldorf
2024
Université de Bordeaux
2024
Abstract The Hopkins Verbal Learning Test (HVLT) is a brief verbal learning and memory test with six alternate forms. HVLT ideal in situations calling for repeated neuropsychological examinations, but it lacks delayed recall trial which essential the assessment of abnormal forgetting. We present revised version includes trial, therefore delays yes/no recognition trial. equivalence forms was examined two separate studies using between-groups within-subjects research designs. In both studies,...
Cognitive impairment occurs in roughly 50% of patients with multiple sclerosis (MS). It is well known that processing speed and episodic memory deficits are the most common neuropsychological (NP) sequelae this illness. Consensus has emerged about specific tests prove helpful for routine monitoring MS associated cognitive impairment. The purpose study was to examine validity Minimal Assessment Function (MACFIMS), a recommended battery based on findings an international conference held 2001....
Cognitive and motor performance measures are commonly employed in multiple sclerosis (MS) research, particularly when the purpose is to determine efficacy of treatment. The increasing focus new therapies on slowing progression or reversing neurological disability makes utilization sensitive, reproducible, valid essential. Processing speed a basic elemental cognitive function that likely influences downstream processes such as memory. Multiple Sclerosis Outcome Assessments Consortium (MSOAC)...
There is an increasing demand for alternate-form neuropsychological tests that can be used in clinical trials with little risk of direct practice effect. Although the Brief Visuospatial Memory Test (BVMT) includes six equivalent alternate forms, its administration limited to immediate and 25-min delayed free-recall trial. We now present a revised version BVMT called Test-Revised (BVMT-R) three learning trials, recall trial, yes/no recognition task. A new scoring system, which accounts...
Recent studies have indicated that brain atrophy is more closely associated with cognitive impairment in multiple sclerosis (MS) than are conventional MRI lesion measures. Enlargement of the third ventricle shows a particularly strong correlation impairment, suggesting clinical relevance damage to surrounding structures, such as thalamus. Previous imaging and pathology demonstrated thalamic involvement MS. In this study, we tested hypothesis volume lower MS normal subjects, correlates...
The present investigation examined the validity of revised Hopkins Verbal Learning Test (HVLT-R). In a principal components analysis with varimax rotation, measures new learning and delayed recall loaded on single factor distinguishable from related to general cognitive function visual memory. HVLT-R also correlated most strongly other tests verbal memory relatively weakly test intelligence. Group comparisons showed that normal controls performed better than age- education-matched patients...
Impaired manual dexterity is a frequently reported disability in people with multiple sclerosis (MS) and increasingly prevalent worsening disease. While various tests patient-reported outcome measures are available, the Nine-Hole Peg Test (NHPT) considered as gold standard measure of most used MS research clinical practice. The Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food Drug Administration (FDA), European Medicines Agency (EMA), National...
<h3>Background</h3> Cognition and magnetic resonance imaging correlations are well established in patients with multiple sclerosis (MS), but it is unclear whether lesion burden or atrophy accounts for most of the predictive variance. These indices have been directly compared only a few studies. No such study included measurement third ventricle, which was strongly neuropsychological competence early literature. Furthermore, studies accounted influence age, premorbid intelligence, depression....
An international expert consensus committee recently recommended a brief battery of tests for cognitive evaluation in multiple sclerosis. The Brief International Cognitive Assessment MS (BICAMS) includes mental processing speed and memory. Recognizing that resources validation will vary internationally, the identified priorities, to facilitate acceptance BICAMS. Practical matters pertaining implementation across different languages countries were discussed. Five steps achieve optimal...
The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders Stroke (NINDS), academic institutions, industry partners along with persons living multiple sclerosis (MS). One the MSOAC goals is acceptance qualification by regulators performance outcomes that are highly reliable valid, practical, cost-effective, meaningful in...
Cognitive impairment is common in multiple sclerosis (MS), yet difficult to detect duringroutine neurologic examination. Therefore, briefscreening tests that identify patients who may benefit from a more thorough assessment or treatment are needed. We investigated the utility of Symbol Digit Modalities Test (SDMT) as screen for cognitive dysfunction because it can be administered and scored about 5 minutes. One hundred MS 50 healthy controls, matched on demographic variables, participated...
The need for more robust outcomes in multiple sclerosis (MS) clinical trials has been a main priority of the field decades. Dissatisfaction with existing measures led to several consensus meetings and initiatives over past few decades hopes defining gaining acceptance that are valid, reliable, sensitive change progression, most importantly, relevant those living MS. Multiple Sclerosis Outcome Assessments Consortium (MSOAC) was formed this purpose.The objective paper is describe results MSOAC...
Since there is a need for cost-effective screening techniques to identify neuropsychological impairment in multiple sclerosis (MS) patients, and because existing methods require cognitive testing with subsequent interpretation by neuropsychologist, brief self-report procedure was developed screen MS. In the first phase of study, pool 80 items generated based on literature review consultation healthcare professionals. The set reduced 15 via Rasch analysis. Using these items, (five minute) MS...