A5012331212- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Neuroimaging Techniques and Applications
- Ethics in Clinical Research
- Cerebrovascular and Carotid Artery Diseases
- Hemoglobinopathies and Related Disorders
- Health disparities and outcomes
- Advanced Chemical Sensor Technologies
- Blood groups and transfusion
- Neuroscience and Neuropharmacology Research
- Brain Tumor Detection and Classification
- Anesthesia and Neurotoxicity Research
- Patient-Provider Communication in Healthcare
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Biochemical Analysis and Sensing Techniques
- Health Literacy and Information Accessibility
- Medical Image Segmentation Techniques
Northern California Institute for Research and Education
2009-2025
San Francisco VA Medical Center
2013-2025
University of California System
2025
University of California, San Francisco
1998-2025
Advanced Imaging Research (United States)
2021-2025
Research Triangle Park Foundation
2014
University of Southern California
2014
Children's Hospital of Los Angeles
2014
University of Miami Hospital
2014
Institute for Neurodegenerative Disorders
2012-2014
Context: Most neuroimaging studies of posttraumatic stress disorder (PTSD) have focused on potential abnormalities in the whole hippocampus, but subfields this structure, which distinctive histological characteristics and specialized functions, not been investigated.Studies individual may clarify role hippocampus PTSD.Objective: To determine if PTSD is associated with structural alterations specific hippocampus.Design: Case-control study.Participants: A total 17 male veterans combat trauma...
Objective: We evaluated the effect of divalproex sodium formulation valproic acid on brain volumes using MRI in people with mild to moderate Alzheimer disease (AD) and assessed for changes associated behavioral cognitive effects. Methods: Eighty-nine 313 participants randomized or placebo a 24-month, parallel-group trial received scans at baseline 12 months. Interval annual percent whole brain, ventricular, hippocampal were primary outcomes interest. Change from clinical was 6-month...
A bstract : Background: The main goals are to investigate the effects of chronic active heavy drinking on N ‐acetylaspartate (NAA) and other metabolites throughout brain determine whether they affected by family history (FH) alcoholism long‐term pattern. Methods: Forty‐six drinkers (HD) 52 light (LD) were recruited from community compared measures regional structure using magnetic resonance imaging common in gray matter (GM) white (WM) major lobes, subcortical nuclei, brainstem, cerebellum...
The goal of this study was to assess the relationship between Aβ deposition and white matter pathology (i.e., hyperintensities, WMH) on microstructural integrity matter. Fifty-seven participants (mean age: 78±7 years) from an ongoing multi-site research program who spanned spectrum normal mild cognitive impairment (Clinical dementia rating 0–0.5) low high risk factors for arteriosclerosis WMH (defined as volume >0.5% total intracranial volume) were assessed with positron emission tomography...
Abstract Introduction The purpose of this study is to compare online neuropsychological test performance older adults across self‐reported diagnoses being cognitively normal, mild cognitive impairment, and dementia due Alzheimer's disease determine the association memory concerns family history on performance. Methods Participants completed Cogstate Brief Battery unsupervised at home. Results Data from 6463 participants over age 55 years were analyzed. Adults with diagnosis impairment...
<h3>Objective:</h3> This study was conducted to determine the relationship of frontal lobe cortical thickness and basal ganglia volumes measures cognition in adults with sickle cell anemia (SCA). <h3>Methods:</h3> Participants included 120 SCA no history neurologic dysfunction 33 healthy controls (HCs). were enrolled at 12 medical center sites, raters blinded diagnostic group. We hypothesized that individuals would exhibit reductions cortex reduced thalamus compared HCs these structural...
The Clinical Dementia Rating (CDR) is a well-validated instrument widely used to detect and stage dementia due Alzheimer disease. digital Electronic (eCDR) can be remotely self-administered automatically scored, with potential facilitate efficient screening staging.To evaluate the association of eCDR CDR other in-clinic assessments for older adults cognitive impairment.This multisite, cross-sectional study baseline data from longitudinal, observational 2020 2023, including up 3 years...
This study aimed to understand whether older adults' longitudinal completion of assessments in an online Alzheimer's disease and related dementias (ADRD)-related registry is influenced by self-reported medical conditions.
Methods for efficiently identifying cognitive decline and Alzheimer's disease (AD) are a critical unmet need. The goal of this work was to validate novel online study partner (SP)-reported outcomes identify in older adults.
Abstract Introduction This culturally tailored enrollment effort aims to determine the feasibility of enrolling 5000 older Latino adults from California into Brain Health Registries (BHR) over 2.25 years. Methods paper describes (1) development and deployment BHR websites digital ads, in collaboration with a community science partnership board marketing company; (2) an interim analysis efforts numbers, participant characteristics (primary aim); as well (3) exploration module completion...
Abstract Backgrounds Digital, online assessments are efficient means to detect early cognitive decline, but few studies have investigated the relationship between remotely collected subjective change and decline. We hypothesized that Everyday Cognition Scale (ECog), a measure, predicts longitudinal in cognition Brain Health Registry (BHR), an registry for neuroscience research. Methods This study included BHR participants aged 55 + who completed both baseline ECog repeated administrations of...
Importance Subjective report of cognitive and functional decline from participant–study partner dyads can efficiently assess risk impairment clinical progression. Accuracy self-report subjective may be limited by lack awareness about one’s own abilities in adults with MCI dementia, the extent to which discordance between self- study partner–report is associated diagnosis unknown. Objective To investigate association partner–reported and/or diagnosis. Design, Setting, Participants This...
Abstract INTRODUCTION Many longitudinal Alzheimer's disease studies fail to retain Black American adults once enrolled. This limits the generalizability of research findings. METHODS The Community‐Engaged Digital Research (CEDAR) study developed digital, culturally‐informed, community‐engaged efforts increase registry task completion Brain Health Registry (BHR) participants. Difference‐in‐differences analysis was conducted compare rates within groups (before vs. after CEDAR referral) and...
Abstract Introduction Assessment of functional status is associated with risk cognitive decline and diagnosis dementia, can be assessed by participants study partners (SPs). Methods In 770 older adults enrolled in the Imaging Dementia‐Evidence for Amyloid Scanning (IDEAS) online Brain Health Registry (BHR), we estimated associations between assessments clinical variables related to Alzheimer's disease (AD) risk. Results Worse learning scores SP‐reported were higher probability AD dementia...
A previous study (Haley RW, Marshall WW, McDonald GG, Daugherty MA, Petty F, Fleckenstein JL: Brain abnormalities in Gulf War syndrome: evaluation with 1H MR spectroscopy. Radiology 2000; 215: 807–817) suggested that individuals Illness (GWI) had reduced quantities of the neuronal marker N-acetylaspartate (NAA) basal ganglia and pons. This aimed to determine whether NAA is these regions investigate correlations other possible causes GWI, such as psychological response stress a large cohort...