A5039519781- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- 3D Printing in Biomedical Research
- Natural Language Processing Techniques
- Alzheimer's disease research and treatments
- Speech and dialogue systems
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Semiconductor materials and devices
- Immune cells in cancer
- Acute Myeloid Leukemia Research
- Topic Modeling
- Adipokines, Inflammation, and Metabolic Diseases
- Hematopoietic Stem Cell Transplantation
- Dental Implant Techniques and Outcomes
- Erythrocyte Function and Pathophysiology
- Prostate Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Integrated Circuits and Semiconductor Failure Analysis
- Optical Coatings and Gratings
- Cleft Lip and Palate Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Prostate Cancer Treatment and Research
- Dental Radiography and Imaging
- Nanoplatforms for cancer theranostics
- Health, Environment, Cognitive Aging
University of Pennsylvania
2023-2024
Cancer Research Institute
2023-2024
University of Southern California
2016-2024
Washington University in St. Louis
2023-2024
Saint Louis University
2023
Providence College
2017
Children's Hospital of Los Angeles
2017
Brown University
2017
Taiwan Semiconductor Manufacturing Company (Taiwan)
2003
Philips (Netherlands)
2003
A clock relating amyloid positron emission tomography (PET) to time was used estimate the timing of biomarker changes in sporadic Alzheimer disease (AD).
The Clinical Dementia Rating (CDR) is a well-validated instrument widely used to detect and stage dementia due Alzheimer disease. digital Electronic (eCDR) can be remotely self-administered automatically scored, with potential facilitate efficient screening staging.To evaluate the association of eCDR CDR other in-clinic assessments for older adults cognitive impairment.This multisite, cross-sectional study baseline data from longitudinal, observational 2020 2023, including up 3 years...
Background: Recent studies indicate that recombinant human bone morphogenetic protein-2 (rhBMP-2) in a demineralized matrix scaffold is comparable alternative to iliac autograft the setting of secondary alveolar cleft repair. Postreconstruction occlusal radiographs demonstrate improved stock when rhBMP-2/demineralized (DBM) used but lack capacity evaluate growth three dimensions. This study uses cone beam computed tomography provide first clinical evaluation volumetric and density...
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancy (FPDMM) and sporadic myelodysplastic syndrome leukemia. was shown to regulate inflammation multiple cell types. Here we show that required granulocyte-monocyte progenitors (GMPs) epigenetically repress two inflammatory signaling pathways neutrophils: Toll-like receptor 4 (TLR4) type I interferon (IFN) signaling. loss GMPs augments neutrophils' response the TLR4 ligand lipopolysaccharide...
Hypoxia plays a central role in cancer progression and resistance to therapy. We have engineered microdevice platform recapitulate the intratumor oxygen gradients that drive heterogeneous hypoxic landscapes solid tumors. Our design features "tumor section"-like culture by incorporating cell layer between two diffusion barriers, where an gradient is established cellular metabolism physical constraints. confirmed numerical simulation imaging-based sensor measurement. also demonstrated...
Micromilling has great potential in producing microdevices for lab-on-a-chip and organ-on-a-chip applications, but remained under-utilized due to the high machinery costs limited accessibility. In this paper, we assessed machining capabilities of a low-cost 3-D mill polycarbonate material, which were showcased by production microfluidic devices. The study demonstrates that particular is well suited fabrication multi-scale with feature sizes from micrometers centimeters.
Membrane-bound factors expressed by niche stromal cells constitute a unique class of localized cues and regulate the long-term functions adult stem cells, yet little is known about underlying mechanisms. Here, we used supported lipid bilayer (SLB) to recapitulate membrane-bound interactions between hematopoietic (HSCs) cells. HSCs cluster cell factor (mSCF) at HSC-SLB interface. They further form polarized morphology with aggregated mSCF under large protrusion through synergy VCAM-1 on...
Tracking stem cell fate transition is crucial for understanding their development and optimizing biomanufacturing. Destructive single-cell methods provide a pseudotemporal landscape of differentiation but cannot monitor in real time. We established metabolic optical metric using label-free fluorescence lifetime imaging microscopy (FLIM), feature extraction machine learning-assisted analysis, real-time tracking. From library 205 biomarker (MOB) features, we identified 56 associated with...
We present Multi-expert Prompting, a novel enhancement of ExpertPrompting (Xu et al., 2023), designed to improve the large language model (LLM) generation. Specifically, it guides an LLM fulfill input instruction by simulating multiple experts, aggregating their responses, and selecting best among individual aggregated responses. This process is performed in single chain thoughts through our seven carefully subtasks derived from Nominal Group Technique (Ven Delbecq, 1974), well-established...
The transcription factor RUNX1 is mutated in familial platelet disorder with associated myeloid malignancies (FPDMM) and sporadic myelodysplastic syndrome leukemia. regulates inflammation multiple cell types. Here we show that required granulocyte-monocyte progenitors (GMPs) to restrict the inflammatory response of neutrophils toll-like receptor 4 (TLR4) signaling. Loss GMPs increased TLR4 coreceptor CD14 on neutrophils, which contributed neutrophils’ cytokine production ligand...
Abstract INTRODUCTION Alzheimer's disease (AD) blood tests are likely to become increasingly important in clinical practice, but they need be evaluated diverse groups before use the general population. METHODS This study enrolled a community‐based sample of older adults St. Louis, Missouri, USA area. Participants completed draw, Eight‐Item Informant Interview Differentiate Aging and Dementia (AD8 ® ), Montreal Cognitive Assessment (MoCA), survey about their perceptions test. A subset...
Abstract Background The double‐blind (DB) period of the DIAN–TU‐001 phase 3 trial with gantenerumab provided evidence significant but incomplete reduction amyloid plaques, cerebrospinal fluid total tau, and phospho‐tau181 in dominantly inherited Alzheimer’s disease (DIAD). 1 Subsequently, eligible participants transitioned to an open‐label extension (OLE) using higher doses (1500mg SC‐administered every two weeks [q2w]). Method 73 DIAD entered OLE period. All titrated received at least 120,...
The final passivation layer affects the electrical behavior of a device and also influences various failure mechanisms in device, package, product reliability by its interaction with metal layers underneath packaging material above it. In order to address issues involved, several schemes have been evaluated. A scheme using PECVD-TEOS combination other PECVD films for 0.7- mu m 0.5- CMOS SRAM processes is proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML"...
As the technology pushes down to half-micron or below, a low flow angle BPSG film for pre- metal dielectric (PMD) becomes necessary. With high BP concentration BPSG, example 4 X 6, can be achieved after proper reflow. The drawback is that, frequently, crystal appears at smaller poly spacing. combined sub-atmosphere chemical vapor deposition (SACVD) and films through in-situ in applied materials P-5000D system was implemented not only improve reflow but also suppress formation any space. A...
ABSTRACT INTRODUCTION Alzheimer’s disease (AD) blood tests are likely to become increasingly important in clinical practice, but need be evaluated diverse groups before use the general population. METHODS This study enrolled a community-based sample of older adults Saint Louis, Missouri, USA area. Participants completed draw, AD8® dementia screening interview, Montreal Cognitive Assessment (MoCA), and survey about their perceptions test. A subset participants additional collection, amyloid...
Abstract Background Alzheimer’s disease (AD) blood tests are needed to aid in the evaluation of dementia, but performance these should be evaluated diverse groups and real‐world settings. The goals Study Evaluate Amyloid Blood Imaging Related Dementia (SEABIRD) were enroll 1120 participants determine participant acceptability validity (relative amyloid PET) a plasma amyloid‐β 42/40 test diverse, community‐based sample older adults, explore impact important factors (age, race, education,...
You have accessJournal of UrologyModerated Poster 16, Sunday, May 20, 2007, 3:30 - 5:30 pm1 Apr 2007534: Evaluation New Prostate Cancer Specific Secretory Protein Panel in Serum Patients Kee-Hong Kim, Jaroslaw Tuszynski, Daniel Yen, Gyorgy Petrovics, Albert Dobi, David G. McLeod, and Shiv Srivastava KimKee-Hong Kim More articles by this author , TuszynskiJaroslaw Tuszynski YenDaniel Yen PetrovicsGyorgy Petrovics DobiAlbert Dobi McLeodDavid McLeod SrivastavaShiv View All Author...