A5108693545- Growth Hormone and Insulin-like Growth Factors
- Blood properties and coagulation
- Image Retrieval and Classification Techniques
- Advanced Image and Video Retrieval Techniques
- Cancer, Hypoxia, and Metabolism
- Anomaly Detection Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Advanced Clustering Algorithms Research
- Lipid metabolism and disorders
- Receptor Mechanisms and Signaling
- Polymer Surface Interaction Studies
- Biomarkers in Disease Mechanisms
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Data-Driven Disease Surveillance
- Acute Ischemic Stroke Management
- Machine Learning and Data Classification
- Cancer Cells and Metastasis
- Hemoglobin structure and function
- Neurofibromatosis and Schwannoma Cases
- Brain Tumor Detection and Classification
- Imbalanced Data Classification Techniques
- Protein Tyrosine Phosphatases
- Peptidase Inhibition and Analysis
- Advanced X-ray and CT Imaging
University of Alabama at Birmingham
2007-2025
New York University
2025
China University of Mining and Technology
2025
Harbin Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
University of Atlanta
2019
University of South Carolina
2019
Thomas Jefferson University
2019
Texas Children's Hospital
2019
Baylor College of Medicine
2019
Neurofibromatosis type 1 (NF1) is one of the most frequent genetic disorders, affecting 1:3,000 worldwide. Identification genotype-phenotype correlations challenging because wide range clinical variability, progressive nature disorder, and extreme diversity mutational spectrum. We report 136 individuals with a distinct phenotype carrying five different NF1 missense mutations p.Arg1809. Patients presented multiple café-au-lait macules (CALM) or without freckling Lisch nodules, but no...
Purpose: We propose a systematic methodology to quantify incidentally identified pulmonary nodules based on observed radiological traits (semantics) quantified point scale and machine-learning method using these data predict cancer status.Experimental Design: investigated 172 patients who had low-dose CT images, with 102 70 grouped into training validation cohorts, respectively. On the 24 were systematically scored linear classifier was built relate malignant status. The model formed both...
Abstract Fibrinogen is an extracellular matrix protein composed of three polypeptide chains with fibrinogen alpha (FGA), beta (FGB) and gamma (FGG). Although its related fragments are involved in tumor angiogenesis metastasis, their functional roles incompatible. A recent genome-scale screening reveals that loss FGA affects the acceleration growth metastasis lung cancer, but mechanism remains elusive. We used CRISPR/Cas9 genome editing to knockout (KO) human adenocarcinoma (LUAD) cell lines...
Wound healing is a complex process initiated by the formation of fibrin fibers and endothelialization. Normally, this triggered in wound thrombin cleavage fibrinopeptides on fibrinogen molecules, which allows them to self spontaneously-assemble into large that provide support structure clot promote healing. We have found fibrous structures can also form without most polymer or metal surfaces, including those commonly used for stents. show relatively hydrophobic E D regions molecule are...
Growth hormone (GH) receptor (GHR) and (full-length) prolactin (PRL) (PRLR) are transmembrane class I cytokine receptors that co-exist in various normal cancerous cells. Both respond to their associated ligands predominantly by activating the Janus Kinase 2 (JAK2)-signal transducer activator of transcription (STAT) signaling pathways, both also known initiate receptor-specific JAK2-independent signaling. Together with cognate ligands, these have been pro-tumorigenic effects cancers,...
ABSTRACT Aging is associated with increased retinal cell apoptosis, which contributes to decreases in function. Apoptotic clearance relies on microglial efferocytosis, but the impact of aging this process has not been fully elucidated. In study, we aimed shed light by using single‐cell RNA sequencing (sc‐RNA‐seq) compare young and aged mouse transcriptional profiles, 74,412 cells from mice were classified into 10 transcriptionally distinct types, differentially expressed genes between versus...
GH signaling yields multiple anabolic and metabolic effects. binds the transmembrane receptor (GHR) to activate intracellular GHR-associated tyrosine kinase, Janus kinase 2 (JAK2), downstream signals, including signal transducer activator of transcription 5 (STAT5) activation IGF-1 gene expression. Some effects are partly mediated by GH-induced via (IGF-1R), a receptor. We previously demonstrated in non-human cells that causes formation GHR-JAK2-IGF-1R complex presence IGF-1R (even without...
Growth hormone receptor (GHR) and prolactin (PRL) (PRLR) are homologous transmembrane class I cytokine receptors. In humans, GH interacts with GHR homodimers or PRLR PRL only to promote signaling. human breast cancer cells endogenously expressing both receptors, specifically coimmunoprecipitate. We previously devised a split luciferase complementation assay study assemblages. this technique, firefly is into two fragments (N- C-terminal of the luciferase), each without enzyme activity...
The transmembrane GH receptor (GHR) exists at least in part as a preformed homodimer on the cell surface. Structural and biochemical studies suggest that binds GHR 1:2 stoichiometry to effect acute conformational changes trigger activation of receptor-associated tyrosine kinase, Janus kinase 2 (JAK2), downstream signaling. Despite information about GHR-GHR association derived from elegant fluorescence resonance energy transfer/bioluminescence transfer studies, an assessment dynamics...
This paper introduces a novel method to separate abnormal points from normal data, based on network flow. approach uses the Maximum Flow Minimum Cut theorem graph theory find outliers and strong outlier groups, evaluate by degrees. Similar are discovered together delivered user together; in an application where of greatest interest, this will allow similar be analysed together. Effectiveness is demonstrated comparison with three other detection algorithms. Further experimental testifies...
Apart from medications, pulsed electromagnetic fields (PEMFs) are used to treat osteoporosis nowadays. However studies on hemorheological safety of PEMFs were scarce. This randomized, placebo controlled clinical trial assessed whether could lea
This paper proposes a semantic clustering scheme to reduce search space and gap, two most challenging tasks in content-based image retrieval. By performing before retrieval, the can be reduced those clusters that are close query target. In proposed method, sub-regions/segments grouped into terms of their meanings addition low level features. Ideally, one cluster approximates concept or small set closely related concepts; hence "semantic gap" retrieval phase is reduced. The experimental...
This paper proposes a semantic clustering scheme to reduce search space and gap, two most challenging tasks in content-based image retrieval. By performing before retrieval, the can be reduced those clusters that are close query target. In proposed method, sub-regions/segments grouped into terms of their meanings addition low level features. Ideally, one cluster approximates concept or small set closely related concepts; hence gap retrieval phase is reduced. The experimental results show...