A5012837986- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Neurobiology and Insect Physiology Research
- Autophagy in Disease and Therapy
- Cervical and Thoracic Myelopathy
- Cardiovascular Disease and Adiposity
- Spine and Intervertebral Disc Pathology
- Invertebrate Immune Response Mechanisms
- Diabetes and associated disorders
- DNA Repair Mechanisms
- Renal Diseases and Glomerulopathies
- Spinal Fractures and Fixation Techniques
- Chronic Kidney Disease and Diabetes
- Barrier Structure and Function Studies
- Lipid metabolism and biosynthesis
- Metabolism, Diabetes, and Cancer
- Effects of Radiation Exposure
- Cellular transport and secretion
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Peroxisome Proliferator-Activated Receptors
- Genetics, Aging, and Longevity in Model Organisms
- Analog and Mixed-Signal Circuit Design
University of Oklahoma Health Sciences Center
2016-2025
University of Alabama at Birmingham
2024-2025
Chengdu Medical College
2024
Chengdu Second People's Hospital
2024
Army Medical University
1997-2023
Southern Medical University
2018-2023
Daping Hospital
2023
Iowa Diabetes and Endocrinology Research Center
2021
Sun Yat-sen Memorial Hospital
2020
Sun Yat-sen University
2020
Recent findings suggest that Delta/Serrate/Lag2 (DSL) signals activate Notch by an unprecedented mechanism requires the ligands to be endocytosed in signal-sending cells receptor signal-receiving cells. Here, we show devoid of Epsin, a conserved adaptor protein for Clathrin-mediated endocytosis, behave normally except they cannot send DSL signals. Surprisingly, find Epsin is not required bulk endocytosis proteins. Instead, appears essential targeting proteins special endocytic pathway must...
Ligands of the Delta/Serrate/Lag2 (DSL) family must normally be endocytosed in signal-sending cells to activate Notch signal-receiving cells. DSL internalization and signaling are promoted zebrafish Drosophila, respectively, by ubiquitin ligases Mind bomb (Mib)and Neuralized (Neur). activity also depends on Epsin, a conserved endocytic adaptor thought target mono-ubiquitinated membrane proteins for internalization. Here, we present evidence that Drosophila ortholog Mib (Dmib) is required...
RORγt is necessary for the generation of TH17 cells but molecular mechanisms regulation are still not fully understood. We show that activation CD4+ T results in expression inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced cell differentiation without major effects on either TH1 or TH2 lineages, whereas endothelial NOS (eNOS) neuronal (nNOS) mutant showed comparable compared with wild-type control mice. The addition N6-(1-iminoethyl)-l-lysine dihydrochloride...
ABSTRACT The Hmx homeobox gene family is of ancient origin, being present in species as diverse Drosophila, sea urchin and mammals. three members the murine family, designated Hmx1, Hmx2 Hmx3, are expressed tissues that suggest a common functional role sensory organ development pregnancy. Hmx3 one earliest markers for vestibular inner ear during embryogenesis, also upregulated myometrium uterus Targeted disruption results mice with abnormal circling behavior severe defects owing to depletion...
The epidemic of obesity and diabetes is causing an increased incidence dyslipidemia-related heart failure. While the primary etiology lipotoxic cardiomyopathy elevation lipid levels resulting from imbalance in energy availability expenditure, increasing evidence suggests a relationship between dysregulation membrane phospholipid homeostasis lipid-induced cardiomyopathy. In present study, we report that Drosophila easily shocked ( eas ) mutants harbor disturbance phosphatidylethanolamine (PE)...
To identify small molecules that can induce beta-cell replication, a large chemical library was screened for proliferation of growth-arrested, reversibly immortalized mouse beta cells by using an automated high-throughput screening platform. A number structurally diverse, active compounds were identified, including phorbol esters, which likely act through protein kinase C, and group thiophene-pyrimidines stimulate activating the Wnt signaling pathway. dihydropyridine (DHP) derivatives also...
The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based screens using rodent lines to identify molecules induce cells. Herein we report the discovery characterization WS6, novel small molecule promotes in human primary islets. In RIP-DTA mouse model ablation, WS6 normalized blood glucose induced concomitant increases number. Affinity...
Reactive oxygen species (ROS) can act cell autonomously and in a paracrine manner by diffusing into nearby cells. Here, we reveal ROS-mediated signaling mechanism that does not require entry of ROS target We found under physiological conditions, nonmyocytic pericardial cells (PCs) the Drosophila heart contain elevated levels compared to neighboring cardiomyocytes (CMs). show PCs regulate normal cardiac function, CMs exert their but eliciting downstream D-MKK3-D-p38 MAPK cascade acts on...
Abstract Pericytes have been identified as a major source of myofibroblasts in renal interstitial fibrosis (RIF). The overactivation several signaling pathways, mainly the TGF-β and PDGF initiates pericyte-myofibroblast transition during RIF. Key receptors these two pathways shown to be modified by fucosyltransferase 8 (FUT8), enzyme that catalyzes core fucosylation. This study postulated fucosylation might play an important role regulating pericyte data showed increased with extent RIF...
To investigate the association between level of serum brain-derived neurotrophic factor (sBDNF) and therapeutic efficacy modified electroconvulsive therapy (MECT) in Chinese patients with depressive disorder.Twenty-eight episode 28 healthy subjects were recruited current study. The sBDNF was examined all before treatment after a 2-week MECT depression. severity depression measured according to 17-item Hamilton Rating Scale for Depression depression.The reduced significantly (31.39 [SD, 4.65]...
Abstract Adipose thermogenesis has been actively investigated as a therapeutic target for improving metabolic dysfunction in obesity. However, its applicability to middle‐aged and older populations, which bear the highest obesity prevalence United States (approximately 40%), remains uncertain due age‐related decline thermogenic responses. In this study, we effects of chronic stimulation using β3‐adrenergic (AR) agonist CL316,243 (CL) on systemic metabolism adipose function aged...
The heart has emerged as an important organ in the regulation of systemic lipid homeostasis; however, underlying mechanism remains poorly understood. Here, we show that Drosophila cardiomyocytes regulate metabolism by producing apolipoprotein B-containing lipoproteins (apoB-lipoproteins), essential carriers are so far known to be generated only fat body. In a genetic screen, discovered when haplo-insufficient, microsomal triglyceride transfer protein (mtp), required for biosynthesis...
Overnutrition engenders the expansion of adipose tissue and accumulation immune cells, in particular, macrophages, tissue, leading to chronic low-grade inflammation insulin resistance. In obesity, several proinflammatory subpopulations macrophages (ATMs) identified hitherto include conventional “M1-like” CD11C-expressing ATM newly discovered metabolically activated CD9-expressing ATM; however, relationship among is unclear. The ER stress sensor inositol-requiring enzyme 1α (IRE1α) adipocytes...
Overnutrition engenders the expansion of adipose tissue and accumulation immune cells, in particular, macrophages, tissue, leading to chronic low-grade inflammation insulin resistance. In obesity, several proinflammatory subpopulations macrophages (ATMs) identified hitherto include conventional “M1-like” CD11C-expressing ATM newly discovered metabolically activated CD9-expressing ATM; however, relationship among is unclear. The ER stress sensor inositol-requiring enzyme 1α (IRE1α) adipocytes...
Overnutrition engenders the expansion of adipose tissue and accumulation immune cells, in particular, macrophages, tissue, leading to chronic low-grade inflammation insulin resistance. In obesity, several proinflammatory subpopulations macrophages (ATMs) identified hitherto include conventional ‘M1-like’ CD11C-expressing ATM newly discovered metabolically activated CD9-expressing ATM; however, relationship among is unclear. The ER stress sensor inositol-requiring enzyme 1α (IRE1α) adipocytes...
Nuclear receptor Peroxisome Proliferator-Activated Receptor γ (PPARγ) is a promising target for the treatment of type 2 diabetes. The antidiabetic drug thiazolidinediones (TZDs) are potent insulin sensitizers as full agonists PPARγ, but cause unwanted side effects. Recent discoveries have shown that TZDs improve sensitivity by blocking PPARγ phosphorylation at S273, which decouples agonism-associated ligands act through blockage lack agonist activity would be expected to without...
Thermogenic brown or beige adipocytes dissipate energy in the form of heat and thereby counteract obesity related metabolic complications. The miRNA cluster miR-130b/301b is highly expressed adipose tissues has been implicated diseases as a posttranscriptional regulator mitochondrial biogenesis lipid metabolism. We investigated roles regulating adipogenesis vivo vitro. declined progenitor cells during adipogenesis, while forced overexpression miR-130b-3p miR-301b-3p suppressed uncoupling...
Overnutrition engenders the expansion of adipose tissue and accumulation immune cells, in particular, macrophages, tissue, leading to chronic low-grade inflammation insulin resistance. In obesity, several proinflammatory subpopulations macrophages (ATMs) identified hitherto include conventional "M1-like" CD11C-expressing ATM newly discovered metabolically activated CD9-expressing ATM; however, relationship among is unclear. The ER stress sensor inositol-requiring enzyme 1α (IRE1α) adipocytes...