A5061066198- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Medical Imaging and Analysis
- Bone health and treatments
- Pelvic and Acetabular Injuries
- Management of metastatic bone disease
- Bone Metabolism and Diseases
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
- Bone fractures and treatments
- Bone health and osteoporosis research
- Bone Tissue Engineering Materials
- Axon Guidance and Neuronal Signaling
- Anesthesia and Pain Management
- Spinal Cord Injury Research
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Inflammatory mediators and NSAID effects
- Bone Tumor Diagnosis and Treatments
- Cytokine Signaling Pathways and Interactions
Army Medical University
2014-2025
Xinqiao Hospital
2013-2022
Chongqing Medical University
2019
Dalian Medical University
2019
Second Affiliated Hospital of Chongqing Medical University
2019
National Natural Science Foundation of China
2012
Daping Hospital
2009
Background: Recently, more clinicians have realized the importance of quality life in treatment decision-making process. The goal this study was to determine whether surgery for patients with spinal metastases from non-small-cell lung cancer (NSCLC) could improve their and prolong survival. Methods: included 133 who had been treated NSCLC between 2010 2014. These were divided into two groups according or not they received surgery. Their assessed use Functional Assessment Cancer...
In a general view of anatomy, intervertebral disc is composed three parts: annulus fibrosus (AF), nucleus pulposus (NP), and cartilage endplate (CEP). Recently, several types stem cells were successfully isolated from these corresponding regions, but up to now, no research was performed about which kind the most efficient candidate for NP tissue engineering or cell-based regeneration therapy. this study, we compared regenerative potentials above-mentioned kinds disc-derived with that classic...
To examine the histopathological changes in spinal tissues of ankylosing spondylitis (AS) patients.Tissue samples from 10 AS patients and control subjects were obtained. Hematoxylin eosin, picrosirius, Masson van Gieson stainings utilized to determine pathological tissues. Ultrastructural alterations examined by electronic microscopy. Proteoglycan levels assessed enzyme-linked immunosorbent assays (ELISA). Matrix metalloproteinase-3 (MMP-3), transforming growth factor-β1 (TGF-β1) tumor...
Prospective randomized cohort study.To compare the surgical results of minimally invasive posterior decompression combined with percutaneous pedicle screws fixation (minimally surgery [MIS]) and open (OS) for treatment thoracolumbar fracture neurological deficits.Thoracolumbar deficits usually undergoes intervention. OS can achieve satisfied results, but main disadvantage is approach-related complications. No study, however, focused on this disease by MIS through approach.Sixty consecutive...
Spinal cord injury (SCI) remains among the most challenging pathologies worldwide and has limited therapeutic possibilities a very bleak prognosis. Biomaterials stem cell transplantation are promising treatments for functional recovery in SCI. Seven patients with acute complete SCI diagnosed by combination of methods were included study, different lengths (2.0–6.0 cm) necrotic spinal tissue surgically cleaned under intraoperative neurophysiological monitoring. Subsequently, NeuroRegen...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors endangering human health and life in 21st century. Chromatin licensing DNA replication factor 1 (CDT1) an important regulator licensing, which essential for initiation replication. CDT1 overexpression several cancers reportedly leads to abnormal cell replication, activates damage checkpoints, predisposes transformation. However, expression HCC its diagnostic prognostic value remains be elucidated.TCGA, ONCOMINE,...
Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear. Via conducting a series biochemical experiments with in vitro cell lines, this study investigated role mechanism NADPH oxidase 4 (Nox4) RANKL-induced autophagy osteoclastogenesis. In current study, we that RANKL dramatically induced osteoclastogenesis, inhibition chloroquine (CQ) markedly attenuates Interestingly,...
Purpose: To explore the incidence and risk factors for adjacent segment disease (ASD) in patients with lumbar degenerative diseases after transforaminal interbody fusion (TLIF). Patients Methods: The clinical data of 1258 who underwent (TLIF) our hospital from January 2011 to December 2017 were retrospectively analyzed. divided into ASD group non-ASD (N-ASD) group, was calculated. We compared age, BMI, comorbidities, surgery-related parameters, imaging parameters before surgery between two...
Study Design A case-controlled retrospective study. Objective We aimed to explore the effectiveness of MRI-based VBQ scores derived by different MRI sequences in assessing risk an osteoporotic vertebral compression fracture (OVCF) age- and sex-controlled patients. Methods This study included patients hospitalized for OVCF (fracture group) degenerative lumbar disease (non-fracture from July 2022 2024. Patients both groups were matched sex age a 1:1 ratio. acquired non-contrast lumbosacral...
Introduction In a general view of anatomy, intervertebral disc is composed three parts: annulus fibrosus, nucleus pulposus (NP), and cartilage endplate. Recently, several types stem cells were successfully isolated from these corresponding regions, but up to now, no research was performed about which kind the most efficient candidate for NP tissue engineering or cell-based regeneration therapy. Materials Methods this study, we compared regenerative potentials above-mentioned kinds...
To evaluate the surgical procedure of endo-scopic transforminal discectomy, bone grafting and Dynalok pedicle screw fixation under X-Tube operation system in treatment lumbar disc herniation combined with segmental instability and/or pars defected spondylolithesis. From June 2004 to May 2006, 42 patients classic features spondylolithesis underwent endoscopic interbody fusion (TLIF). Under guidance fluoroscopy, a 2.8 3.0 cm incision 4.5 5.0 apart from posterior middle line was made on...
This is a prospective, consecutive series study to determine the role of Bryan artificial cervical disc replacement treat isolated herniation for Chinese patients.To evaluate intermediate clinical outcome and its limitations in management patients. Observing neurological improvement radiographic finding.Most people believe that anterior fusion factor shall not be ignored adjacent segment degeneration. Artificial replacement, as nonfusion technique, may offer solution this problem. The...
This is a prospective study of artificial disk replacement combined with cage fusion for the treatment multilevel cervical herniation.To evaluate clinical outcome Bryan adjacent segment in patients herniation. To observe neurological improvement and interpret radiographic findings.It generally considered that 1-level had an excellent intermediate outcome. There was no final conclusion about disease. The negative factors include possible complication, high cost, contraindication at one...
BACKGROUND Prostate cancer metastasis to bone is the second most commonly diagnosed malignant disease among men worldwide. Such metastatic characterized by presence of osteoblastic lesions, and associated with high rates mortality. However, various mechanisms involved in prostate cancer-induced differentiation have not been fully explored. Semaphorin 3A (Sema 3A) a newly identified regulator metabolism which stimulates pre-osteoblastic cells under physiological conditions. We investigated...