A5044825462- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Cytokine Signaling Pathways and Interactions
- Periodontal Regeneration and Treatments
- Bone health and osteoporosis research
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Circular RNAs in diseases
- Bone and Dental Protein Studies
- Cell Adhesion Molecules Research
- Silk-based biomaterials and applications
- TGF-β signaling in diseases
- Advanced Nanomaterials in Catalysis
- Tendon Structure and Treatment
- Signaling Pathways in Disease
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Trace Elements in Health
- Graphene and Nanomaterials Applications
Army Medical University
2016-2025
Southwest Hospital
2015-2025
Southwest University
2025
Chongqing University
2023
University of Pittsburgh
2013
Chondrogenic differentiation of mesenchymal stem cells (MSCs) is accurately regulated by essential transcription factors and signaling cascades. However, the precise mechanisms involved in this process still remain to be defined. MicroRNAs (miRNAs) regulate various biological processes binding target mRNA attenuate protein synthesis. To investigate for miRNAs-mediated regulation chondrogenic differentiation, we identified that miR-145 was decreased during transforming growth factor beta 3...
Abstract Bone is a dynamic organ continuously undergoing shaping, repairing and remodeling. The homeostasis of bone maintained by the balance between osteoblastic formation osteoclastic resorption. Osteoclasts (OCs) are specialized multinucleated cells derived from hematopoietic stem (HSCs) or monocytes/macrophage progenitor cells. There different stages during osteoclastogenesis, one most important steps to form functional osteoclasts realized cell-cell fusion. In our study, microarray was...
ABSTRACT In this study, for the first time we discovered that M1/M2 macrophage phenotype ratio is increased in bone marrow of ovariectomized (OVX) osteoporotic C57BL/6 mice. Considering estrogen main variable, assumed participated alteration. To determine whether and how contributes to change ratio, isolated macrophages (BMMs) from mice femur stimulated cells with lipopolysaccharide (LPS)/interferon γ (IFN-γ) M1 polarization interleukin 4 (IL-4)/IL-13 M2 polarization. were then exposed RANKL...
Insufficient blood perfusion is one of the critical problems that hamper clinical application tissue engineering bone (TEB). Current methods for improving vessel distribution in TEB mainly rely on delivering exogenous angiogenic factors to promote proliferation, migration, differentiation, and formation endothelial cells (ECs) and/or progenitor (EPCs). However, obstacles including limited activity preservation, difficulty controlled release, high cost obstructed practical this strategy. In...
Osteoporosis is caused by an osteoclast activation mechanism. People suffering from osteoporosis are prone to bone defects. Increasing evidence indicates that scavenging reactive oxygen species (ROS) can inhibit receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclastogenesis and suppress ovariectomy-induced osteoporosis. It critical develop biomaterials with antioxidant properties modulate activity for treating osteoporotic Previous studies have shown manganese (Mn) improve...
Abstract The objective of this study is to design a graphene‐based miRNA transfection drug delivery system for antiresorptive therapy. An efficient nonviral gene developed using polyethylenimine (PEI) functionalized graphene oxide (GO) complex loaded with miR‐7b overexpression plasmid. GO‐PEI exhibits excellent efficiency within the acceptable range cytotoxicity. after GO‐PEI‐miR‐7b significantly abrogates osteoclast (OC) fusion and bone resorption activity by hampering expression an...
Abstract A variety of osteolytic factors have been identified from breast cancer cells leading to osteolysis, but less is known about which factor plays an essential role in the initiation process prior overt vicious cycle. Here, we present vitro and vivo evidences clarify interleukin-11 (IL-11) as contributor bone metastasis mediated osteolysis. Animal studies showed that specific metastatic BoM-1833 induce earlier onset osteolysis faster tumor growth compared with MCF7 parental MDA-MB-231...
Abstract Bone remodeling is precisely coordinated by bone resorption and formation. Apoptotic osteoclasts generate large amounts of apoptotic bodies (ABs) marking the end phase, whereas functions osteoclast-derived ABs remain largely unknown. Here, we identified molecular profile derived from at distinct differentiation stages investigated their corresponding functions. were isolated marrow macrophages, preosteoclasts, mature induced staurosporine. Proteomic signature analysis with liquid...
Antiresorptive drugs are widely used for treatment of osteoporosis and cancer bone metastasis, which function mainly through an overall inhibition osteoclast. However, not all osteoclasts "bone eaters"; preosteoclasts (pOCs) play anabolic roles in formation angiogenesis coupling with osteoblasts secreting platelet derived growth factor-BB (PDGF-BB). In this study, a bone-targeted pH-responsive nanomaterial was designed selectively eliminating mature (mOCs) without affecting pOCs....
Reactive oxygen burst in articular chondrocytes is a major contributor to osteoarthritis progression. Although selenium indispensable role the antioxidant process, narrow therapeutic window, delicate toxicity margins, and lack of an efficient delivery system have hindered its translation clinical applications. Herein, transcriptomic biochemical analyses revealed that was associated with metabolic abnormality. A novel injectable hydrogel deliver nanoparticles (SeNPs) proposed intervene...
Abstract The occurrence of peritendinous adhesion, which hampers the quality and function healed tendon, is strongly linked to oxidative stress, inflammatory, infection that occur after surgery. Tendon damage repair provide a considerable obstacle for regenerative medicine owing absence patches possess comprehensive functionality, including self‐healing capacity, anti‐inflammatory anti‐bacterial properties, as well tissue guidance. A dual dynamic crosslinked network created by coordination...
Osteoarthritis (OA) is a devastating whole-joint disease affecting large population worldwide; the role of lipid dysregulation in OA and mechanisms underlying targeted therapy effect lipid-lowering metformin on remains poorly defined. To investigate effects progression to explore dysregulation-targeting treatment metformin. RNA-Seq data, biochemical, histochemical assays human murine cartilage as well primary chondrocytes were utilized determine dysregulation. Effects metformin, potent...
The development of pre-recruitment follicles plays a critical role in determining egg-laying performance poultry. This study combines proteomic and metabolomic analyses to explore changes proteins metabolites, elucidate key regulatory mechanism involved chicken follicular development. Histological examination revealed significant increase yolk deposition small yellow (SYF) compared white (SWF). Metabolomics analysis identified significantly enriched differential metabolites (DMs) between SWF...
Completely repairing of damaged cartilage is a difficult procedure. In recent years, the use tissue engineering approach in which scaffolds play vital role to regenerate has become new research field. Investigating advances biological been regarded as main direction and great significance for construction artificial cartilage. Native materials synthetic polymeric have their advantages disadvantages. The disadvantages can be overcome through either physical modification or biochemical...