Julia‐Katharina Pfarr
A5080868397- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Tryptophan and brain disorders
- Child Abuse and Trauma
- Genetics and Neurodevelopmental Disorders
- Advanced MRI Techniques and Applications
- Stress Responses and Cortisol
- Obsessive-Compulsive Spectrum Disorders
- Suicide and Self-Harm Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Genetic Associations and Epidemiology
- Autism Spectrum Disorder Research
- Adolescent and Pediatric Healthcare
- Neonatal and fetal brain pathology
- Electrolyte and hormonal disorders
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Personality Disorders and Psychopathology
- COVID-19 and Mental Health
- Hemispheric Asymmetry in Neuroscience
- Traumatic Brain Injury Research
Philipps University of Marburg
2020-2025
Brain (Germany)
2020-2025
Center for Behavioral Brain Sciences
2020-2025
Justus-Liebig-Universität Gießen
2020-2024
The Center for Mind-Body Medicine
2023
Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting equivocal findings. We carried out largest case–control study structural asymmetries with MRI data from 5,080 affected individuals 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global regional cortical thickness, surface...
Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one the most prevalent and disabling disorders, major depressive disorder (MDD), no informative biomarkers have been identified.
Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It unclear whether such alterations progressively change over time, how this related to the number of mood episodes. To address question, we analyzed a large diverse international sample longitudinal magnetic resonance imaging (MRI) clinical data examine changes time in BD.Longitudinal MRI from ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307...
Abstract Major depressive disorder (MDD), bipolar (BD), and schizophrenia spectrum (SSD, schizophrenia, schizoaffective disorder) overlap in symptomatology, risk factors, genetics, other biological measures. Based on previous findings, it remains unclear what transdiagnostic regional gray matter volume (GMV) alterations exist across these disorders, with which factors they are associated. GMV (3-T magnetic resonance imaging) was compared between healthy controls (HC; n = 110), DSM-IV-TR...
Abstract Schizophrenia is frequently associated with obesity, which linked neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto changes in schizophrenia. We obtained MRI-derived cortical and subcortical measures body mass index (BMI) from 1260 individuals schizophrenia 1761 controls 12 independent research sites within ENIGMA-Schizophrenia Working Group. jointly modeled statistical effects BMI using mixed effects. was additively structure many...
Schizotypy is a risk phenotype for the psychosis spectrum and pilot studies suggest biological continuum underlying this across health disease. It unclear whether might include brain structural associations in networks altered schizophrenia disorders, such as fronto-thalamo-striatal system or nodes of default mode network, precuneus. In study, we analyze large multi-center cohort 673 nonclinical subjects phenotyped schizotypal traits (using Schizotypal Personality Questionnaire-Brief...
Retrospective self-reports of childhood maltreatment (CM) are widely used. However, their validity has been questioned due to potential depressive bias. Yet, investigations this matter sparse. Thus, we investigated what extent retrospective reports vary in relation longitudinal changes symptomatology. Two-year temporal stability was assessed via the Childhood Trauma Questionnaire (CTQ). Diagnosis major disorder (MDD) and symptoms were using Structured Clinical Interview for DSM-IV Beck...
Abstract Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived subcortical volumes and body mass index (BMI) 1134 1601 control individuals 17 independent research sites within ENIGMA-BD Working Group. jointly modeled BMI using mixed-effects modeling tested for mediation group differences by nonparametric bootstrapping. All...
Childhood maltreatment (CM) represents a potent risk factor for major depressive disorder (MDD), including poorer treatment response. Altered resting-state connectivity in the fronto-limbic system has been reported maltreated individuals. However, previous results smaller samples differ largely regarding localization and direction of effects.We included healthy depressed [n = 624 participants with MDD; n 701 control (HC) participants] that underwent functional MRI measurements provided...
Syntax, the grammatical structure of sentences, is a fundamental aspect language. It remains debated whether reduced syntactic complexity unique to schizophrenia spectrum disorder (SSD) or it also present in major depressive (MDD). Furthermore, association syntax (including and diversity) with language-related neuropsychology psychopathological symptoms across disorders unclear. Thirty-four SSD patients thirty-eight MDD diagnosed according DSM-IV-TR as well forty healthy controls (HC) were...
Speech is a promising biomarker for schizophrenia spectrum disorder (SSD) and major depressive (MDD). This proof of principle study investigates previously studied speech acoustics in combination with novel application voice pathology features as objective reproducible classifiers depression, schizophrenia, healthy controls (HC). classification were calculated from recordings picture descriptions 240 samples (20 participants SSD, 20 MDD, HC each 4 samples). Binary support vector machine...
Numerous studies have implicated involvement of the hippocampus in etiology and expression schizophrenia-spectrum psychopathology, reduced hippocampal volume is one most robust brain abnormalities reported schizophrenia. Recent indicate that early stages schizophrenia are specifically characterized by reductions anterior volume; however, not examined subclinical schizotypy. The present study was first to examine associations positive, negative, disorganized schizotypy dimensions with...
Abstract Formal thought disorder (FTD) is a complex syndrome affecting language and processes in psychotic affective disorders. Clustering (i.e., identification of data-driven clinical subtypes) establishes latent (sub-) structures into psychopathological syndromes. A profile analysis (LPA) FTD symptoms was conducted 1 032 patients diagnosed with Schizophrenia-Spectrum-Disorders (n = 107), Major Depressive 800), Bipolar Disorder 125). Clusters were compared for cognition psychopathology....
Abstract Cognitive deficits are central attendant symptoms of major depressive disorder (MDD) with a crucial impact in patients’ everyday life. Thus, it is particular clinical importance to understand their pathophysiology. The aim this study was investigate possible relationship between brain structure and cognitive performance MDD patients well-characterized sample. N = 1007 participants ( 482, healthy controls (HC): HC 525) were selected from the FOR2107 cohort for diffusion-tensor...
MRI-derived cortical folding measures are an indicator of largely genetically driven early developmental processes. However, the effects genetic risk for major mental disorders on brain development not well understood.
Abstract Background Two prominent risk factors for major depressive disorder (MDD) are childhood maltreatment (CM) and familial MDD. Despite having these factors, there individuals who maintain mental health, i.e. resilient, whereas others develop It is unclear which brain morphological alterations associated with this kind of resilience. Interaction analyses diagnosis status needed that can account complex adaptation processes, to identify neural correlates Methods We analyzed structural...
Abstract Aberrant brain structural connectivity in major depressive disorder (MDD) has been repeatedly reported, yet many previous studies lack integration of different features MDD with multivariate modeling approaches. In n = 595 patients, we used equation (SEM) to test the intercorrelations between anhedonia, anxiety, neuroticism, and cognitive control one comprehensive model. We then separately analyzed diffusion tensor imaging (DTI) measures association those clinical variables, finally...