A5050846056- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Advanced Neuroimaging Techniques and Applications
- Bipolar Disorder and Treatment
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Birth, Development, and Health
- Schizophrenia research and treatment
- Child Abuse and Trauma
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Mindfulness and Compassion Interventions
- Neonatal Respiratory Health Research
- Obsessive-Compulsive Spectrum Disorders
- Psychosomatic Disorders and Their Treatments
- Neurotransmitter Receptor Influence on Behavior
- Dermatology and Skin Diseases
- Heart Rate Variability and Autonomic Control
- Eating Disorders and Behaviors
- Hormonal Regulation and Hypertension
- Health, psychology, and well-being
Philipps University of Marburg
2021-2025
Brain (Germany)
2023-2025
Justus-Liebig-Universität Gießen
2008-2025
Center for Behavioral Brain Sciences
2024-2025
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2025
Universitätsklinikum Gießen und Marburg
2023
MSH Medical School Hamburg – University of Applied Sciences and Medical University
2015-2022
University Hospital Carl Gustav Carus
2020
Technische Universität Dresden
2012-2020
University of Bath
2020
Although exposure to supraphysiological levels of glucocorticoids is known contribute the development metabolic syndrome (MetS), importance physiological variation in basal cortisol secretion less clear. This issue can be addressed by using hair analysis, which for first time allows assessment long-term integrated hormone levels.We used analysis (hairF) examine associations with prevalence MetS and individual cardiometabolic parameters a large occupational cohort. In additional exploratory...
Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one the most prevalent and disabling disorders, major depressive disorder (MDD), no informative biomarkers have been identified.
Antenatal glucocorticoid (GC) exposure has been discussed as a potent programming factor of hypothalamus-pituitary-adrenal (HPA) axis activity, producing sustained alterations in cortisol secretion throughout life. So far, the assessment HPA-axis activity offspring mothers treated with synthetic GC limited to time period shortly after birth, prematurity being an important confound most prior studies.The present study aimed investigate reactivity term-born children antenatal larger sample,...
The serotonin transporter (SERT) gene-linked polymorphic region (5-HTTLPR) has been implicated in moderating the link between life stress and depression. However, respective molecular pathways of gene–environment (GxE) interaction are largely unknown. Sustained alterations SERT gene expression profiles, possibly mediated by epigenetic modifications, a frequent correlate depression may thus constitute putative mediator GxE interaction. Here, we aimed to investigate joint effects 5-HTTLPR...
Abstract Up to 70% of patients with major depressive disorder present psychomotor disturbance (PmD), but at the time understanding its pathophysiology is limited. In this study, we capitalized on a large sample examine neural correlates PmD in depression. This study included 820 healthy participants and 699 remitted ( n = 402) or current 297) Patients were further categorized as having retardation, agitation, no PmD. We compared resting-state functional connectivity (ROI-to-ROI) between...
Temporal neural synchrony disruption can be linked to a variety of symptoms major depressive disorder (MDD), including mood rigidity and the inability break cycle negative emotion or attention biases. This might imply that altered dynamic may play role in persistence exacerbation MDD symptoms. Our study aimed investigate changes whole-brain patterns brain functional connectivity activity related depression using hidden Markov model (HMM) on resting-state magnetic resonance imaging (rs-fMRI)...
Abstract Formal thought disorder (FTD) is a complex syndrome affecting language and processes in psychotic affective disorders. Clustering (i.e., identification of data-driven clinical subtypes) establishes latent (sub-) structures into psychopathological syndromes. A profile analysis (LPA) FTD symptoms was conducted 1 032 patients diagnosed with Schizophrenia-Spectrum-Disorders (n = 107), Major Depressive 800), Bipolar Disorder 125). Clusters were compared for cognition psychopathology....
The 5-HTTLPR is an insertion/deletion polymorphism in the promoter region of serotonin transporter gene. Prior research has revealed associations between short-allele variant this polymorphism, enhanced self-reported negative emotionality, and hypersensitivity fear relevant neural circuits. In a sample 50 healthy women we examined role for cognitive-affective processing phylogenetical fear-relevant stimuli (spiders) dot probe task. contrast to homozygote long-allele carriers (ll),...
The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been implicated in moderating vulnerability to stress-related psychopathology upon exposure environmental adversity. A recent meta-analysis suggests a potential biological pathway conveying genotype-dependent stress sensitivity by demonstrating small, but significant association of 5-HTTLPR and cortisol reactivity. An arguably more potent approach detect larger effects when investigating the hypothesis is account for...
Background The current study aimed to assess prevalence of mental disorders during Covid-19 pandemic- and respective lockdown in Germany, potential behaviors/states that can have protective functions on preventing severe problems. Assessing disorders, as well find variables is very important order determine people's psychological suffering. It provides the basis for teaching possible coping styles prevent a major breakdown health. Prevalence was expected increase pandemic, especially...