A5043336955- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Gut microbiota and health
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Stress Responses and Cortisol
- EEG and Brain-Computer Interfaces
- Mental Health Treatment and Access
- Transcranial Magnetic Stimulation Studies
- Folate and B Vitamins Research
- Maternal Mental Health During Pregnancy and Postpartum
- COVID-19 and Mental Health
- Heart Rate Variability and Autonomic Control
- Sleep and related disorders
- Neural dynamics and brain function
- Psychosomatic Disorders and Their Treatments
- Child and Adolescent Psychosocial and Emotional Development
- Gastrointestinal motility and disorders
- Growth Hormone and Insulin-like Growth Factors
- Long-Term Effects of COVID-19
Guangzhou Medical University
2016-2025
Fujian Medical University
2024
Nanjing Medical University
2024
Guangzhou Psychiatric Hospital
2013-2023
NYU Langone Health
2022
South China University of Technology
2022
Southern Medical University
2019-2021
Changhai Hospital
2021
Second Military Medical University
2021
Jiangsu Institute of Parasitic Diseases
2019
The methodology of machine learning with multi-omics data has been widely adopted in the discriminative analyses schizophrenia, but most these studies ignored cooperative interactions and topological attributes networks. In this study, we constructed three types brain graphs (BGs), gut (GGs), nine brain-gut combined (BGCGs) for each individual. We proposed a novel graph convolutional network (MO-GCN) an attention mechanism to construct classification model by integrating all BGCGs. also...
Previous studies have indicated that major depressive disorder (MDD) patients with suicidal ideation (SI) present abnormal functional connectivity (FC) and network organization in node-centric brain networks, ignoring the interactions among FCs. Whether abnormalities of edge affect emergence SI are related to gene expression remains largely unknown. In this study, resting-state magnetic resonance imaging (fMRI) data were collected from 90 first-episode, drug-naive MDD (MDDSI) patients, 60...
Background Convergent studies provide support for abnormalities in the structure and functioning of prefrontal cortex (PFC) amygdala, key components neural system that subserves emotional processing major depressive disorder (MDD). We used resting-state functional magnetic resonance imaging (fMRI) to examine potential amygdala–PFC connectivity treatment-naive subjects with MDD. Methods Resting-state fMRI data were acquired from 28 individuals MDD 30 healthy control (HC) subjects....
The gut microbiome and microbiome-gut-brain (MGB) axis have been receiving increasing attention for their role in the regulation of mental behavior possible biological basis psychiatric disorders. With advance next-generation sequencing technology, characterization microbiota schizophrenia (SZ) patients can provide rich clues diagnosis prevention SZ.In this study, we compared differences fecal between 82 SZ 80 demographically matched normal controls (NCs) by 16S rRNA analyzed correlations...
Structural abnormalities in schizophrenia (SZ) patients have been well documented with structural magnetic resonance imaging (MRI) data using voxel-based morphometry (VBM) and region of interest (ROI) analyses. However, these analyses can only detect group-wise differences thus, a poor predictive value for individuals. In the present study, we applied machine learning method that combined support vector (SVM) recursive feature elimination (RFE) to discriminate SZ from normal controls (NCs)...
The effect of the gut microbiome on central nervous system and its possible role in mental disorders have received increasing attention. However, knowledge about relationship between brain structure function is still very limited. Here, we used 16S rRNA sequencing with structural magnetic resonance imaging (sMRI) resting-state functional (rs-fMRI) to investigate differences fecal microbiota 38 patients schizophrenia (SZ) demographically matched normal controls (NCs) explored whether such...
Background: Anxiety has been a common mental state during the epidemic of Coronavirus Disease 2019 (COVID-19) and is usually closely related to somatization. However, no study on somatization in anxiety its relationship with insomnia conducted. Therefore, this aimed identify prevalence anxiety, explore relationships between different psychological states general population COVID-19 outbreak. Methods: A total 1172 respondents were recruited from 125 cities mainland China by an online...
The COVID-19 pandemic has led to worldwide school closures, with millions of children confined online learning at home. As a result, may be susceptible anxiety and digital eye strain, highlighting need for population interventions.The objective our study was investigate whether behavior change intervention aimed promoting physical activity could reduce children's strain while undergoing prolonged homeschooling during the pandemic.In this cluster randomized controlled trial, homeschooled...
Abstract Background Although clozapine is an effective option for treatment-resistant schizophrenia (TRS), there are still 1/3 to 1/2 of TRS patients who do not respond clozapine. The main purpose this randomized, double-blind, placebo-controlled trial was explore the amisulpride augmentation efficacy on psychopathological symptoms and cognitive function clozapine-resistant treatment-refractory (CTRS) patients. Methods A total 80 were recruited randomly assigned receive initial plus...
Abstract Childhood maltreatment (CM) confers a great risk of maladaptive development outcomes later in life, however, the neurobiological mechanism underlying this vulnerability is still unclear. The present study aimed to investigate long‐term consequences CM on neural connectivity while controlling for psychiatric conditions, medication, and, substance abuse. A sample including adults with ( n = 40) and without 50) completed Trauma Questionnaire (CTQ), personality questionnaires,...
The microbiome-gut-brain axis (MGBA) plays a critical role in schizophrenia (SZ). However, the underlying mechanisms of interactions among gut microbiome, brain networks, and symptom severity SZ patients remain largely unknown. Fecal samples, structural functional magnetic resonance imaging (MRI) data, Positive Negative Syndrome Scale (PANSS) scores were collected from 38 normal controls, respectively. data 16S rRNA gene sequencing used to analyze abundance microbiome analysis human networks...
Abstract The overlapping clinical features of Alzheimer's disease ( AD ) and Dementia with Lewy bodies DLB make differentiation difficult in the environment. Evaluating CSF levels biomarkers patients could facilitate diagnosis. Visinin‐like protein‐1 VILIP ‐1), a calcium‐mediated neuronal injury biomarker, has been described as novel biomarker for . aim this study was to investigate diagnostic utility ‐1 ‐1/Aβ 1–42 ratio distinguish from Levels ‐1, t‐tau, p‐tau 181P , Aβ α‐synuclein were...
Abstract Abnormal subcortical structures have been associated with major depressive disorder (MDD) and could be reversed by antidepressant treatment. To date no study has examined the relationship between volumes repeated ketamine The current investigated volume changes in specific hippocampal subfields after six infusions. Forty-four patients MDD received subanesthetic dose infusions of ketamine. Depressive symptoms were assessed magnetic resonance imaging scans performed before FreeSurfer...
Alexithymia is a common, but less-recognized affective deficit in patients with schizophrenia. To date, no definitive conclusions have been drawn about the relationship between alexithymia and clinical symptoms or their correlates, particularly stable The purpose of this study was to investigate link psychopathological symptoms, as well any associated A total 435 Chinese schizophrenia were recruited. Positive Negative Symptoms Scale (PANSS) used evaluate each patient's symptoms. Toronto...
Schizophrenia is a polygenetic disease, the heterogeneity of which likely complicated by epigenetic modifications yet to be elucidated. Here, we performed transcriptomic analysis peripheral blood RNA from monozygotic twins discordant for schizophrenia and identified schizophrenia-associated down-regulated microRNA, miR-501-3p. We showed that loss miR-501-3p in germline knockout (KO) male mice resulted dendritic structure defects, glutamatergic transmission enhancement, sociability, memory,...