A5100392248- Renin-Angiotensin System Studies
- Nitric Oxide and Endothelin Effects
- Adenosine and Purinergic Signaling
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Plant-derived Lignans Synthesis and Bioactivity
- Plant-based Medicinal Research
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Advanced Glycation End Products research
- Magnolia and Illicium research
- Mental Health Research Topics
- Bioactive Natural Diterpenoids Research
- Migraine and Headache Studies
- Cardiac electrophysiology and arrhythmias
- Clinical Laboratory Practices and Quality Control
- Scientific Measurement and Uncertainty Evaluation
- Pesticide Residue Analysis and Safety
- Neurological Disorders and Treatments
- Traditional and Medicinal Uses of Annonaceae
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
Chinese Academy of Sciences
2009-2022
Shanghai Institute of Materia Medica
2009-2022
National Center for Clinical Laboratories
2016
Beijing Hospital
2016
Xuan Wu Hospital of the Capital Medical University
2016
Institute for Biological Sciences
2009
Texas A&M University System
2001-2004
Texas A&M University
2004
Medical University of South Carolina
2004
Previous studies have indicated that major depressive disorder (MDD) patients with suicidal ideation (SI) present abnormal functional connectivity (FC) and network organization in node-centric brain networks, ignoring the interactions among FCs. Whether abnormalities of edge affect emergence SI are related to gene expression remains largely unknown. In this study, resting-state magnetic resonance imaging (fMRI) data were collected from 90 first-episode, drug-naive MDD (MDDSI) patients, 60...
Arginase shares a common substrate, L-arginine, with nitric oxide (NO) synthase (NOS). It is thought that arginase, if it expressed in the endothelium, might play pivotal role regulation of NO-mediated vasodilation by reducing L-arginine availability to NOS. In present study, we wanted determine whether arginase and active coronary arterioles demonstrate endothelial can influence NO production functional regulating dilation. this regard, expression mRNA distribution protein porcine...
One characteristic of hypertension is a decreased endothelium-dependent nitric oxide (NO)-mediated vasodilation; however, the underlying mechanism complex. In endothelial cells (ECs), l -arginine substrate for both NO synthase (NOS) and arginase. Because arginase has recently been shown to modulate NO-mediated dilation coronary arterioles by reducing availability, we hypothesized that upregulation vascular in contributes vasodilation. To test this hypothesis, (mean arterial blood pressure...
A reduction in L-arginine availability has been implicated the impairment of endothelium-dependent nitric oxide (NO)-mediated vasodilation by ischemia-reperfusion (I/R). However, mechanisms contributing to dysregulation pool remain unknown. Because endothelial cells can metabolize via two major enzymes, that is, NO synthase (NOS) and arginase, we hypothesized up-regulation arginase during I/R reduces NOS thus impairs NO-mediated vasodilation. To test this hypothesis, a local was produced...
For evaluation of C18- and C19-diterpenoid alkaloids as analgesics, three were isolated from the roots Aconitum hemsleyanum var. circinatum A. transsecutum; twenty-five semisynthetic or prepared lappaconitine, crassicauline A yunaconitine. In a mice acetic acid-induced abdominal constriction assay, four analogs yunaconitine exhibited good analgesic activities with 77.8—94.1% inhibition range in 0.1—10 mg/kg subcutaneous (s.c.) dose at point 20 min after drug administration. Among them,...
Depression is one of the most frequent psychiatric complications Alzheimer's disease (AD), affecting up to 50% patients. A novel series hybrid molecules were designed and synthesized by combining pharmacophoric features vilazodone tacrine as potential multitarget-directed ligands for treatment AD with depression. In vitro biological assays conducted evaluate compounds; among 30 hybrids, compound 1e showed relatively balanced profiles between acetylcholinesterase inhibition (IC50 = 3.319 ±...
Four new merrillianin-type sesquiterpenes, oligandrumins A−D (1−4), two seco-prezizaane-type veranisatins D and E (5 6), a phenylpropane glycoside, oligandrumin (7), were isolated from the ethanol extract of pericarps Illicium oligandrum, together with six known sesquiterpenoids phenylpropanoids. Their structures established on basis extensive spectroscopic analyses. The 1 2 further confirmed by single-crystal X-ray diffraction experiments. Anislactone B (13) erythro form anethole glycol...
Our previous study had identified ciclopirox (CPX) as a promising lead compound for treatment of ischemic stroke. To find better neuroprotective agents, series N-hydroxypyridone derivatives based on CPX were designed, synthesized, and evaluated in this study. Among these derivatives, 11 exhibits significant neuroprotection against oxygen glucose deprivation oxidative stress-induced injuries neuronal cells. Moreover, possesses good blood-brain barrier permeability superior antioxidant...
Amyloid-β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation are major pathophysiological events in Alzheimer's disease (AD). However, the relationships among these processes which first exerts an effect unknown. In present study, we investigated age-dep endent behavioral changes sequential pathological progression from brain to periphery AD transgenic (PS1V97L-Tg) mice their wild-type littermates. We discovered that Aβ significantly increased at 6 months...
Clinical laboratory tests are important for clinicians to make diagnostic decisions, but discrepancies may directly lead incorrect diagnosis. We would like introduce some statistical methods evaluate the comparability of chemistry analytes while comparing performances different measurement systems.We used a panel 10 fresh-frozen single donation serum samples assess assays glucose and other 13 analytes. Statistical in this article include traditional analysis, robust statistics, regression...