A5061017872- Treatment of Major Depression
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Bipolar Disorder and Treatment
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Electroconvulsive Therapy Studies
- Mental Health Treatment and Access
- Alcoholism and Thiamine Deficiency
- Mental Health Research Topics
- Human Pose and Action Recognition
- Diet and metabolism studies
- Down syndrome and intellectual disability research
- Advanced Image and Video Retrieval Techniques
- interferon and immune responses
- Video Surveillance and Tracking Methods
- Liver Disease Diagnosis and Treatment
- Multimodal Machine Learning Applications
- Musculoskeletal pain and rehabilitation
- Myofascial pain diagnosis and treatment
Tianjin University of Traditional Chinese Medicine
2024-2025
Anhui Medical University
2025
Chongqing Academy of Chinese Materia Medica
2025
Guangzhou Medical University
2015-2024
Southwest Jiaotong University
2024
Nanjing Tech University
2023
Guangzhou Psychiatric Hospital
2013-2021
Soochow University
2019
Albert Einstein College of Medicine
2019
Montefiore Medical Center
2019
Down syndrome (DS) is caused by the presence of an extra copy human chromosome 21 (Hsa21) and most common genetic cause for developmental cognitive disability. The regions on Hsa21 are syntenically conserved with three located mouse 10 (Mmu10), Mmu16 Mmu17. In this report, we describe a new model DS that carries duplications spanning entire syntenic all chromosomes. This mutant exhibits DS-related neurological defects, including impaired behaviors, reduced hippocampal long-term potentiation...
Marijuana has been used for thousands of years as a treatment medical conditions. However, untoward side effects limit its value. Here, we show that synaptic and cognitive impairments following repeated exposure to Δ9-tetrahydrocannabinol (Δ9-THC) are associated with the induction cyclooxygenase-2 (COX-2), an inducible enzyme converts arachidonic acid prostanoids in brain. COX-2 by Δ9-THC is mediated via CB1 receptor-coupled G protein βγ subunits. Pharmacological or genetic inhibition blocks...
Itch is a common symptom of diseases the skin but can also accompany other tissues including nervous system. Acute itch from chemicals experimentally applied to initiated and maintained by action potential activity in subset nociceptive neurons. But whether these pruriceptive neurons are active or might become intrinsically more excitable under pathological conditions that produce persistent sensations humans largely unexplored. Recently, two distinct types cutaneous dorsal root ganglion...
Structural abnormalities in schizophrenia (SZ) patients have been well documented with structural magnetic resonance imaging (MRI) data using voxel-based morphometry (VBM) and region of interest (ROI) analyses. However, these analyses can only detect group-wise differences thus, a poor predictive value for individuals. In the present study, we applied machine learning method that combined support vector (SVM) recursive feature elimination (RFE) to discriminate SZ from normal controls (NCs)...
Objective Depressive disorder is associated with abnormal changes in cytokines levels. This study aimed to assess serum concentrations of tumor necrosis factor (TNF) α, interleukin (IL) 6, and IL-18 depressive patients. The correlations between these three cytokine the patients' clinical characteristics were also assessed. Methods Serum TNF-α, IL-6, assessed using enzyme-linked immunosorbent assay from 64 patients 80 healthy control subjects. symptoms Hamilton Depression Scale-17. Results...
Schizophrenia is correlated with aberrant cytokine concentrations. The goal of our study was to detect the serum concentrations tumor necrosis factor (TNF)-α, interleukin (IL)-18, and IL-6 in patients chronic schizophrenia acute relapse state at admission discharge analyze correlations between three psychosis symptoms. Enzyme-linked immunosorbent assay (ELISA) used TNF-α, IL-18, 68 80 controls. Positive Negative Syndrome Scale (PANSS) symptoms patients. Serum were significantly elevated...
J. Neurochem. (2010) 112 , 691–702. Abstract Chronic use of marijuana impairs synaptic plasticity and cognitive function. However, the molecular mechanisms by which alters long‐term are largely unknown. Here, we show that repeated in vivo exposures to Δ9‐THC for 7 consecutive days significantly impaired hippocampal potentiation (LTP) excitatory glutamatergic transmission. The exposure‐induced decrease LTP was prevented pharmacological inhibition or deletion cannabinoid 1 receptor (CB1R). To...
The level and integrity of glutamate transmission during critical periods postnatal development plays an important role in the refinement pyramidal neuron dendritic arbor, synaptic plasticity, cognition. Presently, it is not clear how excitatory via two predominant isoforms vesicular transporter (VGLUT1 VGLUT2) participate this process. To assess a neurodevelopmental for VGLUT2 maturation, we generated recombinant knock-out mice inactivated throughout using Emx1-Cre +/+ knock-in mice. We...
In early 2020, the COVID-19 outbreak complicated diagnosis, treatment and rehabilitation of patients with substance use disorders increased risks abuse addictive behaviours, such as online gaming disorders, in general public. Substance disorder is a chronic recurrent brain disease characterised by strong cravings, high recurrence rates, proportion comorbidity mental physical disorders.1 Therefore, regular long-term therapeutic interventions are critical to preventing drug relapses while...
Neuropathic pain is a complex, chronic state that often accompanies tissue damage, inflammation or injury of the nervous system. However underlying molecular mechanisms still remain unclear. Here, we showed CXCL12 and CXCR4 were upregulated in dorsal root ganglion (DRG) after compression DRG (CCD), some immunopositive neurons also for nociceptive neuronal markers IB4, TRPV1, CGRP, substance P. The incidence amplitude CXCL12-induced Ca2+ response primary sensory from CCD mice was...
Stigma towards people with mental illness is believed to be widespread in low and middle income countries.This study assessed the attitudes among psychiatrists, psychiatric nurses, involved family members of patients a facility general public using standard 43-item survey (N = 535). Exploratory factor analysis identified four distinctive which were then compared Analysis Covariance (ANCOVA) groups, all ties largest Guangzhou, China, adjusting for sociodemographic differences.Four...
Chronic compression (CCD) of the dorsal root ganglion (DRG) is a model human radicular pain produced by intraforaminal stenosis and other disorders affecting DRG, spinal nerve, or root. Previously, we examined electrophysiological changes in small-diameter lumbar level 3 (L3) L4 DRG neurons treated with CCD; present study extends these observations to medium-sized neurons, which mediate additional sensory modalities, both nociceptive non-nociceptive. Whole-cell patch-clamp recordings were...
Activation of the STING pathway is essential for restoring immune surveillance against dormant disseminated tumor cells (DTCs) in lungs. Inhaled Mn2+ has potential as a agonist; however, its clinical application limited by risk chronic inflammation and metastasis, primarily due to reactive oxygen species (ROS) generation during inhalation. To address these risks, salvianolic acid B (salB) was identified an effective ionophore Mn2+, enhancing activation while mitigating ROS-induced...
We investigated the effects of chronic compression (CCD) L3 and L4 dorsal root ganglion (DRG) on pain behavior in mouse electrophysiological properties small-diameter neuronal cell bodies intact ganglion. CCD is a model human radicular produced by intraforaminal stenosis other disorders affecting DRG, spinal nerve, or root. On days 1, 3, 5, 7 after onset compression, there was significant decrease from preoperative values threshold mechanical force required to elicit withdrawal foot...