A5112548009- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Islamic Finance and Communication
- Autism Spectrum Disorder Research
- Family Caregiving in Mental Illness
- Neurological and metabolic disorders
- Alcoholism and Thiamine Deficiency
- Plant Virus Research Studies
- RNA Research and Splicing
- Circular RNAs in diseases
- Infectious Encephalopathies and Encephalitis
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- RNA regulation and disease
- Advanced Neuroimaging Techniques and Applications
- Cancer-related gene regulation
- Genetic Syndromes and Imprinting
- Tryptophan and brain disorders
Southern Medical University
2016-2022
Chinese PLA General Hospital
2019-2022
Bayi Children's Hospital
2018-2019
Key Laboratory of Guangdong Province
2016-2018
Schizophrenia is a polygenetic disease, the heterogeneity of which likely complicated by epigenetic modifications yet to be elucidated. Here, we performed transcriptomic analysis peripheral blood RNA from monozygotic twins discordant for schizophrenia and identified schizophrenia-associated down-regulated microRNA, miR-501-3p. We showed that loss miR-501-3p in germline knockout (KO) male mice resulted dendritic structure defects, glutamatergic transmission enhancement, sociability, memory,...
Aim: To study DNA methylation patterns of AluY subfamilies in schizophrenia (SCZ) and bipolar disorder (BPD). Patients & methods: A bisulfite conversion-specific one-label extension method was employed to detect the subfamily levels peripheral blood from 92 SCZ patients, 99 BPD patients controls. Results: Hypermethylation A1 A2 CpG sites hypomethylation A3 site both opposite age-dependent alterations between Conclusion: The differentially altered families suggest role pathogenesis these...
Abstract Background The mutations of thiamine pyrophosphokinase-1 ( TPK1 ) gene have been frequently studied in some patients with metabolism dysfunction syndrome-5 (THMD5), while Chinese investigated by only homozygous. A search the literature on population currently published revealed that no reports compound heterozygous were reported. Here, we report a patient who underwent magnetic resonance imaging (MRI), whole exome sequencing (WES), molecular diagnosis, bioinformatics analysis, and...
Objective To investigate the abnormality of white matter by diffusion tensor imaging （DTI） and correlation with clinical symptoms in chronic schizophrenia. Methods Twenty-two schizophrenia patients 16 age-，gender- education-matched healthy controls were recruited. Correlation analysis was used to explore relationship between abnormal brain regions Results Compared controls, had significant increased fractional （FA） right cerebrum middle temporal gyrus（t=4.64,P<0.001） decreased...