A5086148125- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Neural dynamics and brain function
- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- Neonatal and fetal brain pathology
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Neurological disorders and treatments
- Health, Environment, Cognitive Aging
- Optical Imaging and Spectroscopy Techniques
- EEG and Brain-Computer Interfaces
- Neurogenesis and neuroplasticity mechanisms
- Bioinformatics and Genomic Networks
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Peripheral Nerve Disorders
- Adipose Tissue and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Bone and Joint Diseases
- Advanced Manufacturing and Logistics Optimization
Beijing Normal University
2016-2025
Chinese Institute for Brain Research
2016-2025
McGovern Institute for Brain Research
2014-2024
Institut des Sciences Cognitives Marc Jeannerod
2024
Tianjin Medical University
2022-2024
State Key Laboratory of Cognitive Neuroscience and Learning
2024
Massachusetts General Hospital
2024
Institute of Inorganic Chemistry of the Slovak Academy of Sciences
2022
Chan Heart Rhythm Institute
2022
Jiangxi Normal University
2014-2015
Human brain function undergoes complex transformations across the lifespan. We employed resting-state functional MRI and graph-theory approaches to systematically chart lifespan trajectory of topological organization human whole-brain networks in 126 healthy individuals ranging age from 7 85 years. Brain were constructed by computing Pearson's correlations blood-oxygenation-level-dependent temporal fluctuations among 1024 parcellation units followed graph-based network analyses. observed...
Little is currently known about the alterations in topological organization of white matter (WM) structural networks patients with multiple sclerosis (MS). In present study, we used diffusion tensor imaging and deterministic tractography to map WM 39 MS age- gender-matched healthy controls. Graph theoretical methods were applied investigate network efficiency these patients. The controls exhibited efficient small-world properties their networks. However, global local efficiencies...
Alzheimer's disease (AD) is associated not only with regional gray matter damages, but also abnormalities in functional integration between brain regions. Here, we employed resting-state magnetic resonance imaging data and voxel-based graph-theory analysis to systematically investigate intrinsic connectivity patterns of whole-brain networks 32 AD patients 38 healthy controls (HCs). We found that selectively targeted highly connected hub regions (in terms nodal strength) networks, involving...
Alzheimer's disease (AD) can be conceptualized as a disconnection syndrome. Both remitted geriatric depression (RGD) and amnestic mild cognitive impairment (aMCI) are associated with high risk for developing AD. However, little is known about the similarities differences in topological patterns of white matter (WM) structural networks between RGD aMCI. In this study, diffusion tensor imaging deterministic tractography were used to map human WM 35 patients, 38 aMCI 30 healthy subjects....
Attention-deficit/hyperactivity disorder (ADHD), which is characterized by core symptoms of inattention and hyperactivity/impulsivity, one the most common neurodevelopmental disorders childhood. Neuroimaging studies have suggested that these behavioral disturbances are associated with abnormal functional connectivity among brain regions. However, alterations in structural connections underlie deficits remain poorly understood. Here, we used diffusion magnetic resonance imaging probabilistic...
During human brain development through infancy and childhood, microstructural macrostructural changes take place to reshape the brain's structural networks better adapt them sophisticated functional cognitive requirements.However, topological configuration of during this specific period is not well understood.In study, diffusion magnetic resonance image (dMRI) 25 neonates, 13 toddlers, preadolescents were acquired characterize network dynamics at these 3 landmark cross-sectional ages early...
Lifespan is a dynamic process with remarkable changes in brain structure and function. Previous neuroimaging studies have indicated age-related microstructural specific white matter tracts during development aging. However, the alterations topological architecture of structural connectome across human lifespan remain largely unknown. Here, cohort 113 healthy individuals (ages 9-85) both diffusion MRI acquisitions were examined. For each participant, high-resolution networks constructed by...
The link between overload brain iron and transcriptional/cellular signatures in Alzheimer's disease (AD) remains inconclusive. Iron deposition 41 cortical subcortical regions of 30 AD patients 26 healthy controls (HCs) was measured using quantitative susceptibility mapping (QSM). expression 15,633 genes estimated the same transcriptomic data from Allen Human Brain Atlas (AHBA). Partial least square (PLS) regression used to identify association gene transcription aberrant regional QSM signal...
Graph theoretical analysis of brain networks based on resting-state functional MRI (R-fMRI) has attracted a great deal attention in recent years. These analyses often involve the selection correlation metrics and specific preprocessing steps. However, influence these factors topological properties not been systematically examined. Here, we investigated influences metric choice (Pearson's versus partial correlation), global signal presence (regressed or not) frequency band [slow-5 (0.01–0.027...
The topological architecture of the cerebral anatomical network reflects structural organization human brain. Recently, measures based on graph theory have provided new approaches for quantifying large-scale networks. Diffusion MRI studies revealed efficient small-world properties and modular structure in normal subjects. However, no previous study has used diffusion to reveal changes brain early blindness. Here, we utilized tensor imaging construct binary networks 17 blind subjects age-...
Purpose To determine whether individuals with subjective cognitive decline (SCD), which is defined by memory complaints normal performance at objective neuropsychologic examinations, exhibit disruptions of white matter (WM) connectivity and topologic alterations the brain structural connectome. Materials Methods Diffusion-tensor magnetic resonance imaging graph theory approaches were used to investigate organization connectome in 36 participants SCD (21 women: mean age, 62.0 years ± 8.6...
Type 2 diabetes mellitus (T2DM) is associated with a twofold increased risk of dementia and can affect many cognitive abilities, but its underlying cause still unclear. In this study, we used combination battery neuropsychological tests diffusion tensor imaging (DTI) to explore how T2DM affects white matter (WM) integrity cognition in 38 patients 34 age-, sex-, education-matched normal control subjects. A was assess wide range functions. Tract-based spatial statistics combined region...
To investigate the topological alterations of whole-brain white matter structural connectivity in patients with different types amnestic mild cognitive impairment (aMCI), including single-domain (SD) and multidomain (MD) aMCI, to explore relationship such neuropsychologic performance.This study was approved by institutional review board Imaging Center for Brain Research, Beijing Normal University. Written informed consent obtained from each participant. The present involved 38 aMCI (SD n=18;...
Recent research has demonstrated the feasibility of combining functional near-infrared spectroscopy (fNIRS) and graph theory approaches to explore topological attributes human brain networks. However, test-retest (TRT) reliability application metrics these networks remains be elucidated. Here, we used resting-state fNIRS a graph-theoretical approach systematically address TRT as it applies various features networks, including connectivity, global network regional nodal centrality metrics....
<h3>BACKGROUND AND PURPOSE:</h3> Anti-<i>N</i>-methyl-D-aspertate receptor encephalitis is an autoimmune-mediated disease without specific brain MRI features. Our aim was to investigate the MR imaging characteristics of anti-<i>N</i>-methyl-D-aspartate and their associations with clinical outcome at a 2-year follow-up. <h3>MATERIALS METHODS:</h3> We enrolled 53 patients performed Brain MRIs were acquired for all onset phase. The manifestations classified into 4 types: type 1: normal...
Periventricular white matter injury (PWMI) is a high-risk factor for spastic cerebral palsy (SCP). To investigate the geometric microstructural changes in WM infants with PWMI-SCP using MRI which may facilitate early identification. Retrospective cohort study. Twenty-three healthy (aged 6.53-36 months), 25 6-33 and 32 PWMI-nonSCP 6-36 months). 3.0 T, T1-weighted three-dimensional gradient-echo sequence, diffusion tensor imaging (DTI) single-shot gradient echo planar sequence. The brain was...
The human brain is a highly complex system that can be represented as structurally interconnected and functionally synchronized network, which assures both the segregation integration of information processing. Recent studies have demonstrated variety neuroimaging neurophysiological techniques such functional magnetic resonance imaging (MRI), diffusion MRI electroencephalography/magnetoencephalography employed to explore topological organization networks. However, little known about whether...
Some previous reports have suggested that hypertension is a risk factor for dementia and cognitive impairments. Using behavioral data from 1007 elderly human subjects (405 hypertensive patients) of Han ethnicity Beijing, China, the present study aimed to assess effects on performance explore related neuronal changes via advanced resting-state functional magnetic resonance imaging diffusion tensor 84 these (44 patients). Cognitively, we found patients with showed decreased executive functions...