A5011492116- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neural and Behavioral Psychology Studies
- Psychosomatic Disorders and Their Treatments
- Digital Mental Health Interventions
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 and Mental Health
- Resilience and Mental Health
- Autism Spectrum Disorder Research
- Mental Health Treatment and Access
- Neurological disorders and treatments
- Psychiatric care and mental health services
- Neuroendocrine regulation and behavior
- Child Abuse and Trauma
- Obsessive-Compulsive Spectrum Disorders
- Perfectionism, Procrastination, Anxiety Studies
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Early Childhood Education and Development
- Neural dynamics and brain function
Universitätsklinikum Würzburg
2015-2025
Humboldt-Universität zu Berlin
2017-2025
Charité - Universitätsmedizin Berlin
2013-2024
University of Münster
2013-2024
Deutsche Gesellschaft für Psychoanalyse, Psychotherapie, Psychosomatik und Tiefenpsychologie
2024
European Neuroendocrine Tumor Society
2024
Universität Greifswald
2024
University of Würzburg
2015-2024
University of Freiburg
2024
Technische Universität Dresden
2010-2019
The behavioral symptoms of Generalized Anxiety Disorder (GAD) are not well characterized. This study examines in patients with GAD compared to healthy participants, their change during therapy, and role for predicting short- long-term outcome.Secondary data analysis 56 DSM-IV from a randomized controlled trial testing worry exposure (n = 29) applied relaxation 27), 33 demographically matched participants. Participants reported on attempts control or prevent worry, specifically cognitive...
Although neuroimaging research has made substantial progress in identifying the large-scale neural substrate of anxiety disorders, its value for clinical application lags behind expectations. Machine-learning approaches have predictive potential individual-patient prognostic purposes and might thus aid translational efforts psychiatric research.To predict treatment response to cognitive behavioral therapy (CBT) on an level based functional magnetic resonance imaging data patients with panic...
Although exposure-based cognitive-behavioral therapy (CBT) is an effective treatment option for panic disorder with agoraphobia, the neural substrates of response remain unknown. Evidence suggests that agoraphobia characterized by dysfunctional safety signal processing. Using fear conditioning as a neurofunctional probe, authors investigated baseline characteristics and neuroplastic changes after CBT were associated outcome in patients agoraphobia.Neural correlates extinction measured using...
Zusammenfassung. Die COVID-19-Pandemie als multidimensionaler und potenziell toxischer Stressfaktor führt auch in Deutschland zu psychischen Problemen der Allgemeinbevölkerung wird voraussichtlich einen Anstieg Inzidenz- Prävalenzraten psychischer Störungen bedingen. In diesem Positionspapier erfolgt daher eine wissenschaftlich differenzierte Betrachtung psychologischen Auswirkungen auf verschiedene Altersstufen sowie psychische Vulnerabilitäten Störungsbilder, wobei Chancen für die...
Individual responses to behavioral treatment of anxiety disorders vary considerably, which requires a better understanding underlying processes. In this study, we examined the violation and change threat beliefs during exposure. From 8,484 standardized exposure records 605 patients with different disorders, learning indicators were derived: expectancy as mismatch between before occurrence, difference original adjusted after exposure, prediction-error rate extent transferred into change....
Common variation in the gene encoding neuron-specific RNA splicing factor Binding Fox-1 Homolog 1 (RBFOX1) has been identified as a risk for several psychiatric conditions, and rare genetic variants have found causal autism spectrum disorder (ASD). Here, we explored landscape of RBFOX1 more deeply, integrating evidence from existing new human studies well Rbfox1 knockout mice. Mining data large-scale common variants, confirmed gene-based genome-wide association with tolerance, major...
Abstract The COVID-19 pandemic and associated countermeasures had an immensely disruptive impact on people’s lives. Due to the lack of systematic pre-pandemic data, however, it is still unclear how individuals’ psychological health has been affected across this incisive event. In study, we analyze longitudinal data from two healthy samples ( N = 307) provide quasi-longitudinal insight into full trajectory burden before (baseline), during first peak, at a relative downturn pandemic. Our...
Abstract Background Separation anxiety disorder (SEPAD) is characterized by pronounced fear or concerning separation from attachment figures. Despite its high lifetime prevalence, adult SEPAD often remains undetected due to a lack of diagnostic tools in multiple languages. The Adult Anxiety Questionnaire (ASA-27) key instrument for assessing symptoms adults. However, no validated German version available. Objectives This study addressed the translation and validation ASA-27 German-speaking...
Abstract Epigenetic mechanisms such as DNA methylation are hypothesized to play a pivotal role in the pathogenesis of anxiety disorders and predict well relate treatment response. An epigenome-wide association study (EWAS) (Illumina MethylationEPIC BeadChip) was performed at baseline (BL), post-treatment (POST) 6-month follow-up (FU) so far largest longitudinal sample patients with ( N = 415) treated exposure-based cognitive behavioral therapy (CBT), 315 healthy controls. Independent...
Abstract Background Generalized anxiety disorder ( GAD ) is difficult to recognize and hard separate from major depression MD in clinical settings. Biomarkers might support diagnostic decisions. This study used machine learning on multimodal biobehavioral data a sample of , healthy subjects differentiate with (case‐classification) (disorder‐classification). Methods Subjects n = 19), without 14), comparison 24) were included. The was matched regarding age, sex, handedness education free...
Background The need to optimize exposure treatments for anxiety disorders may be addressed by temporally intensified sessions. Effects on symptom reduction and public health benefits should examined across different with comorbid conditions. Methods This multicenter randomized controlled trial compared two variants of prediction error-based therapy (PeEx) in various (both 12 sessions + 2 booster sessions, 100 min/session): (PeEx-I) condensed weeks (n = 358) standard nonintensified (PeEx-S)...
Abstract The goal of this study was to compare brain structure between individuals with generalized anxiety disorder (GAD) and healthy controls. Previous studies have generated inconsistent findings, possibly due small sample sizes, or clinical/analytic heterogeneity. To address these concerns, we combined data from 28 research sites worldwide through the ENIGMA-Anxiety Working Group, using a single, pre-registered mega-analysis. Structural magnetic resonance imaging children adults (5–90...