Lyubomir I. Aftanas
A5017524042- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Spaceflight effects on biology
- Mindfulness and Compassion Interventions
- Health, Environment, Cognitive Aging
- Treatment of Major Depression
- Sleep and related disorders
- Psychosomatic Disorders and Their Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cognitive Science and Mapping
Novosibirsk State University
2016-2023
Scientific Research Institute of Biochemistry
2022-2023
Institute of Physiology and Basic Medicine
2013-2022
Russian Academy of Sciences
2003-2021
Research Institute of Physiology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Medical Sciences
2002-2020
University of Southern California
2019
Radboud University Medical Center
2019
Radboud University Nijmegen
2019
Max Planck Institute for Psycholinguistics
2019
Amsterdam Neuroscience
2019
Alterations in white matter (WM) microstructure have been implicated the pathophysiology of major depressive disorder (MDD). However, previous findings inconsistent, partially due to low statistical power and heterogeneity depression. In largest multi-site study date, we examined WM anisotropy diffusivity 1305 MDD patients 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults adolescents, within Working Group Enhancing Neuroimaging Genetics...
Abstract Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in adult MDD patients, whether this process clinical characteristics a large multicenter international dataset. performed mega-analysis by pooling measures derived from T1-weighted MRI scans 19 samples worldwide. Healthy was estimated predicting chronological age (18–75 years) 7 subcortical volumes, 34 cortical thickness...
Abstract Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between and structure using structural MRI ( n = 6420) genetic data 3907) from ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical subcortical abnormalities in both mass-univariate multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found...
Abstract Background Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced aging in MDD patients, whether this process clinical characteristics a large multi-center international dataset. Methods performed mega-analysis by pooling measures derived from T1-weighted MRI scans 29 samples worldwide. Normative was estimated predicting chronological age (10-75 years) 7 subcortical volumes, 34...
Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown differences brain anatomy between people with major depressive disorder healthy control subjects, few specifically examined anatomical asymmetry relation to this disorder, results from those remained inconclusive. At functional level, some electroencephalography indicated left fronto-cortical hypoactivity right parietal disorders, so...
Abstract It has been difficult to find robust brain structural correlates of the overall severity major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal and investigated this for insomnia, both a key symptom modifiable risk factor MDD. Cortical thickness, surface area subcortical volumes were assessed from T1-weighted magnetic resonance imaging (MRI) scans 1053 MDD patients (age range 13-79 years) 15 cohorts within ENIGMA Working Group. Insomnia was...
The hypothesis was tested of whether neurofeedback training applied in order to increase or decrease power individual EEG frequency ranges is more efficient than standard ranges.The sessions decreasing the theta=beta ratio and reinforcing alpha were carried out on two outpatients with attention deficit disorder (a schoolboy) functional pain contraction professional musician).The utilizing (theta 4-8, 8-12, beta 13-18) inefficient even resulted aggravation symptoms both cases.The...
Tardive dyskinesia is a disorder characterized by involuntary muscle movements that occur as complication of long-term treatment with antipsychotic drugs. It has been suggested to be related malfunctioning the indirect pathway motor part cortical-striatal-thalamic-cortical circuit, which may caused oxidative stress-induced neurotoxicity.The purpose our study was investigate possible association between phosphatidylinositol-4-phosphate-5-kinase type IIa (PIP5K2A) function and tardive in 491...
Attentional biases towards affective stimuli reflect an individual balance of appetitive and aversive motivational systems. Vigilance in relation to threatening information reflects emotional imbalance, associated with somatic problems. It is known that meditation practice significantly improves control attention, which considered be a tool for adaptive regulation. In this regard, the main aim present study was evaluate influence on attentional bias neutral facial expressions. Eyes were...
Traumatic brain injury (TBI) is a major public health problem. Here, we developed novel model of non-invasive TBI induced by laser irradiation in the telencephalon adult zebrafish (Danio rerio) and assessed their behavior neuromorphology to validate evaluate potential targets for neuroreparative treatment. Overall, hypolocomotion anxiety-like tank test, strikingly recapitulating responses mammalian models, hence supporting face validity our model. NeuN-positive cell staining was markedly...
Several studies have evaluated whether depressed persons older appearing brains than their nondepressed peers. However, the estimated neuroimaging-derived "brain age gap" has varied from study to study, likely driven by differences in training and testing sample (size), range, used modality/features. To validate our previously developed ENIGMA brain model identified gap, we aim replicate presence effect size estimate found largest depression date (N = 2126 controls & N 2675 cases; +1.08...