A5062716546- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Dementia and Cognitive Impairment Research
- Fetal and Pediatric Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Spatial Neglect and Hemispheric Dysfunction
- Genetic Associations and Epidemiology
- Neurobiology of Language and Bilingualism
- Health, Environment, Cognitive Aging
- Acute Ischemic Stroke Management
- Cerebral Palsy and Movement Disorders
- EEG and Brain-Computer Interfaces
- Cerebrovascular and Carotid Artery Diseases
- Balance, Gait, and Falls Prevention
- Schizophrenia research and treatment
- Genomic variations and chromosomal abnormalities
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Disease and Adiposity
- Context-Aware Activity Recognition Systems
- Education, Healthcare and Sociology Research
- Spreadsheets and End-User Computing
- Cognitive Science and Mapping
University of Oslo
2017-2024
Sunnaas sykehus
2014-2024
Oslo University Hospital
2018-2024
Warneford Hospital
2020
University of Oxford
2020
Maastricht University
2020
Washington University in St. Louis
2020
Stockholm County Council
2020
Karolinska Institutet
2020
The University of Sydney
2018
To compare the effectiveness of upper extremity virtual reality rehabilitation training (VR) to time-matched conventional (CT) in subacute phase after stroke.In this randomized, controlled, single-blind III multicenter trial, 120 participants with motor impairment within 12 weeks stroke were consecutively included at 5 institutions. Participants randomized either VR or CT as an adjunct standard and stratified according mild moderate severe hand paresis, defined ≥20 degrees wrist 10 finger...
Abstract The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer’s disease (AD) schizophrenia. Given the structural functional heterogeneity of formation, we sought to characterize subfields’ genetic...
Multimodal imaging enables sensitive measures of the architecture and integrity human brain, but high-dimensional nature advanced brain features poses inherent challenges for analyses interpretations. Multivariate age prediction reduces dimensionality to one biologically informative summary measure with potential assessing deviations from normal lifespan trajectories. A number studies documented remarkably accurate prediction, differential trajectories cognitive sensitivity distinct tissue...
Abstract The structure and integrity of the ageing brain is interchangeably linked to physical health, cardiometabolic risk factors (CMRs) are associated with dementia other disorders. In this mixed cross‐sectional longitudinal study (interval mean = 19.7 months), including 790 healthy individuals (mean age 46.7 years, 53% women), we investigated CMRs health indicators anthropometric measures, lifestyle factors, blood biomarkers in relation using MRI‐based morphometry diffusion tensor...
Cognitive deficits are important predictors for outcome, independence and quality of life after stroke, but often remain unnoticed unattended because other impairments more evident. Computerized cognitive training (CCT) is among the candidate interventions that may alleviate difficulties, evidence supporting its feasibility effectiveness scarce, partly due to lack tools outcome prediction monitoring. Magnetic resonance imaging (MRI) provides markers disease monitoring prediction. By...
There is an intimate body-brain connection in ageing, and obesity a key risk factor for poor cardiometabolic health neurodegenerative conditions. Although research has demonstrated deleterious effects of on brain structure function, the majority studies have used conventional measures such as waist-to-hip ratio, waist circumference, body mass index. While sensitive to gross features composition, global anthropometric fail describe regional differences fat distribution composition. The sample...
Novel virtual reality rehabilitation systems provide the potential to increase intensity and offer challenging motivating tasks. The efficacy of improve arm motor function early after stroke has not been demonstrated yet in sufficiently powered studies. objective study is investigate whether VR training as an adjunct conventional therapy more effective improving subacute phase than dose-matched training, assess patient therapist satisfaction when working with novel calculate...
Abstract Post‐stroke fatigue (PSF) is prevalent among stroke patients, but its mechanisms are poorly understood. Many patients with PSF experience cognitive difficulties, studies aiming to identify correlates of have been largely inconclusive. With the aim characterizing relationship between subjective and attentional function, we collected behavioral data using attention network test (ANT) self‐reported scores severity scale (FSS) from 53 patients. In order evaluate utility added value...
Stroke patients commonly suffer from post stroke fatigue (PSF). Despite a general consensus that brain perturbations constitute precipitating event in the multifactorial etiology of PSF, specific predictive value conventional lesion characteristics such as size and localization remains unclear. The current study represents novel approach to assess neural correlates PSF chronic patients. While previous research has focused primarily on location or size, with mixed inconclusive results, we...
Maintaining high levels of daily activity and physical capability have been proposed as important constituents to promote healthy brain cognitive aging. Studies investigating the associations between health in late life have, however, mainly based on self-reported data or measures designed for clinical populations. In current study, we examined cross-sectional activity, recorded by an ankle-positioned accelerometer seven days, (grip strength, postural control, walking speed), neuroimaging...
Abstract Human adolescence is a period of rapid changes in cognition and goal-directed behavior, it constitutes major transitional phase towards adulthood. One the mechanisms suggested to underlie protracted maturation functional brain networks, increased network integration segregation enhancing neural efficiency. Importantly, increasing coordinated interplay throughout development mediated through hubs, which are highly connected areas be pivotal nodes for regulation activity. To elucidate...
Numerous genetic and environmental factors contribute to psychiatric disorders other brain disorders. Common risk likely converge on biological pathways regulating the optimization of structure function across lifespan. Here, using structural magnetic resonance imaging machine learning, we estimated gap between age chronological in 36,891 individuals aged 3 96 years, including with different We show that several are associated accentuated aging, strongest effects schizophrenia, multiple...
Abstract Computerized cognitive training (CCT) combined with transcranial direct current stimulation (tDCS) has showed some promise in alleviating impairments patients brain disorders, but the robustness and possible mechanisms are unclear. In this prospective double‐blind randomized clinical trial, we investigated feasibility effectiveness of combining CCT tDCS, tested predictive value training‐related changes fMRI‐based activation during attentive performance (multiple object tracking)...
Abstract Background Schizophrenia (SZ) and bipolar disorders (BD) share substantial neurodevelopmental components affecting brain maturation architecture. This necessitates a dynamic lifespan perspective in which aberrations are inferred from deviations expected trajectories. We applied machine learning to diffusion tensor imaging (DTI) indices of white matter structure organization estimate compare age between patients with SZ, BD, healthy controls across 10 cohorts. Methods trained six...
A cerebral stroke is characterized by compromised brain function due to an interruption in cerebrovascular blood supply. Although incurs focal damage determined the vascular territory affected, clinical symptoms commonly involve multiple functions and cognitive faculties that are insufficiently explained alone. Functional connectivity (FC) refers synchronous activity between spatially remote regions organized a network of interconnected regions. magnetic resonance imaging (fMRI) has advanced...
Abstract The structure and integrity of the ageing brain is interchangeably linked to physical health, cardiometabolic risk factors (CMRs) are associated with dementia other disorders. In this mixed cross-sectional longitudinal study (interval mean standard deviation = 19.7 ± 0.5 months), including 1062 datasets from 790 healthy individuals (mean (range) age 46.7 (18-94) years, 54% women), we investigated CMRs health indicators anthropometric measures, lifestyle factors, blood biomarkers in...
Cerebral blood flow (CBF) is critical for brain metabolism and function. Age-related changes in CBF are associated with increased risk of neurocognitive disorders vascular events such as stroke. Identifying correlates positive modifiers age-related before the emergence incipient clinical decline may inform public health advice practice. Former research has been inconclusive regarding association between regular physical activity CBF, there a lack studies on level everyday activities older...
Abstract Post-stroke fatigue (PSF) is a prevalent symptom among stroke patients. Its burden pervasive, persistent and associated with poor rehabilitation outcomes, though its mechanisms are poorly understood. Many patients PSF experience cognitive difficulties, but studies aiming to identify correlates of have been largely inconclusive. In contrast conventional neuropsychological assessment, computational modeling behavioral data allows for dissection specific processes group or individual...
Attentional deficits following stroke are common and pervasive, important predictors for functional recovery. functions comprise a set of specific cognitive processes allowing to attend, filter select among continuous stream stimuli. These mechanisms fundamental more complex such as learning, planning control, all crucial daily functioning. The distributed neuroanatomy these is likely explanation the high prevalence attentional impairments stroke, underscores importance clinical...