A5069839127- Psychiatric care and mental health services
- Healthcare Decision-Making and Restraints
- Dementia and Cognitive Impairment Research
- Palliative Care and End-of-Life Issues
- Mental Health and Psychiatry
- Ethics and Legal Issues in Pediatric Healthcare
- Pharmaceutical studies and practices
- COVID-19 and Mental Health
- Memory and Neural Mechanisms
- Child and Adolescent Health
- Health and Medical Studies
- Autoimmune Neurological Disorders and Treatments
- Transcranial Magnetic Stimulation Studies
- Nicotinic Acetylcholine Receptors Study
- Patient-Provider Communication in Healthcare
- Geriatric Care and Nursing Homes
- Electroconvulsive Therapy Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Alzheimer's disease research and treatments
- Historical Psychiatry and Medical Practices
University of Göttingen
2004-2025
Universitätsmedizin Göttingen
2006-2023
Abstract The Covid-19 pandemic highly impacts mental health worldwide. Patients with psychiatric disorders are a vulnerable risk population for worsening of their condition and relapse symptoms. This study investigates the pandemic-related course psychosocial burden in patients pre-existing disorders. With newly developed Goettingen Burden Symptom Inventory (Goe-BSI) has been traced retrospectively (1) before (beginning 2020), (2) at its beginning under maximum lockdown conditions (March (3)...
Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy and cognition. assessed 12 healthy volunteers while performing Attention Network Task 0.4 mg placebo single-blind randomized trial 1.5 T magnetic resonance scanner. Neurocognitive measures included verbal learning, memory, fluency, trail making, digit span, continuous performance task planning (Tower London). When compared to placebo,...
There are several hypotheses on functional neuronal networks that modulate mood states and which might form the neuroanatomical basis of bipolar disorder. The thalamus has been reported to be a key structure within circuits thus play an important role aetiology affective Nevertheless, structural brain imaging studies volume patients have shown heterogeneous results. Using MRI scanning, we compared 41 euthymic well-matched healthy controls. Taking concomitant medication as co-variable patient...
While the COVID-19 pandemic continues, patients with pre-existing mental disorders are increasingly recognized as a risk group for adverse outcomes. However, data conflicting and cover only short time spans so far. Here, we investigate medium-term peri-lockdown-related changes of health outcomes in such longitudinal study. A cohort 159 comprising all major (ICD-10 F0-F9) were interviewed twice Goettingen psychosocial Burden Symptom Inventory (Goe-BSI) to evaluate burden, psychiatric symptoms...
The COVID-19 pandemic has been shown to increase psychological burden and requires efficient coping strategies maintain mental health. In particular, it remains unclear which pandemic-related stress response pattern occurs in pre-existing posttraumatic disorder (PTSD) during the – at same time these patients potentially exhibit dysfunctional of artificially generated psychosocial stressors. To analyze this so far widely unconsidered PTSD, study longitudinally measured adjustment (AD) symptom...
Cholinergic neurotransmission has been implicated in memory and attention. We investigated the effect of non-competitive nicotinic antagonist mecamylamine on three components attention processes (i.e. alerting, orienting executive control) 12 healthy male subjects whilst performing Attention Network Task (ANT) a magnetic resonance imaging (MRI) scanner. Participants received 15 mg single blind placebo-controlled randomized procedure 90 min prior to obtaining functional MRI data. Our results...
This study explores the attitude of German psychiatrists in leading positions towards joint crisis plans and psychiatric advance directives. topic was examined by contacting 473 medical directors hospitals departments. They were asked to complete a questionnaire developed us. That form contained questions about incidence acceptance directives previous experiences with them. 108 departments responded (response rate: 22.8%). Their answers demonstrate that their these documents are rarely used....
Objectives: Clinical trials in humans Germany—as many other countries—must be approved by local research ethics committees (RECs). The current study has been designed to document and evaluate decisions of chairpersons RECs the problematic field non-therapeutic with minors. authors’ purpose was examine whether acceptable for at all, there certainty on how decide involving more than minimal risk. Design: In a questionnaire, REC had five different scenarios (in parts) research. described...
Abstract Background Research with persons dementia is important to better understand the causes of and develop more effective diagnostics, therapies, preventive measures. Advance Directives (ARDs) have been suggested as a possible solution include in research an ethically sound way. Little known about how people, especially those affected by cognitive impairment, regard use ARDs, empirical studies are mainly conducted healthy, non-cognitively impaired, participants. Methods This qualitative...
(1) Background: Homer-3 antibodies are associated with cerebellar disease ranging from subacute degeneration to cerebellitis. However, cognitive impairment autoantibodies has not been reported until now. (2) Methods: in retrospect, we systematically studied clinical, cranial magnetic resonance imaging (cMRI), electroencephalography (EEG) and lumbar puncture data, including neural of a clinical case. (3) Results: describe the case 56-year-old woman presenting amnestic mild association serum...
The purpose of the study was to evaluate current clinical practice Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation in German psychiatry. Case-based data (> 1.000.000 cases) were collected according §21 hospital remuneration law from January 2015 December 2017. cohort comprises approximately 35-40% annual psychiatric cases hospitals Germany. Frequency ECT rTMS investigated considering main diagnoses ICD-10 treatment settings (inpatient vs. day-care). with short-term...
Background Modern genetics have in many ways revolutionized clinical routine and have, for instance, shown that formerly distinct disease entities relate to common pathogenic mutations. One such example is the connection between dementia amyotrophic lateral sclerosis (ALS) a continuous spectrum affirmed by discovery of shared Case Report We describe new variant FIG4 gene patient with slowly progressing frontotemporal (FTD) probable primary (PLS). The initially showed depressive symptoms...
Abstract: Societal and scientific interest in the prediction early diagnosis of Alzheimer’s disease is growing. However, decisions regarding must be well-considered. The decision-making process requires specific counseling for concerned individuals, which currently missing. In our project “Well Advised”, we investigate needs expectations people about their memory services Germany. Using a mixed-methods approach, analyze evaluative interviews from telephone ( n = 44) one expert focus group...
Objective The treatment of patients with dementia poses a considerable challenge to regional district general hospitals, particularly in rural areas. Here we report the establishment and initial evaluation dementia-specific consultation service provided by teaching hospital-based Psychiatry Department hospitals surrounding smaller towns. Methods was pre-existing or newly suspected dementia, who were acute hospital care for concurrent conditions. An 61 consultations – 49 on-site 12 via...