A5024164269- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Parasitic Diseases Research and Treatment
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Adolescent and Pediatric Healthcare
- Genetic Syndromes and Imprinting
- Nutrition, Genetics, and Disease
- Genomics and Rare Diseases
- BRCA gene mutations in cancer
- Parasites and Host Interactions
- Immune Cell Function and Interaction
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Ethics in Clinical Research
- Maternal Mental Health During Pregnancy and Postpartum
- Autism Spectrum Disorder Research
- Global Maternal and Child Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health, Environment, Cognitive Aging
- Per- and polyfluoroalkyl substances research
- Air Quality and Health Impacts
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2017-2025
National Institutes of Health
2016-2025
Eunice Kennedy Shriver Center
2018-2023
University of Utah
2020-2022
Johnson University
2022
Rutgers, The State University of New Jersey
2022
Rutgers Sexual and Reproductive Health and Rights
2022
Huntsman Cancer Institute
2022
University of Washington
2022
Health and Human Development (2HD) Research Network
2021
Given the importance of Africa to studies human origins and disease susceptibility, detailed characterization African genetic diversity is needed. The Genome Variation Project provides a resource with which design, implement interpret genomic in sub-Saharan worldwide. represents dense genotypes from 1,481 individuals whole-genome sequences 320 across Africa. Using this resource, we find novel evidence complex, regionally distinct hunter-gatherer Eurasian admixture We identify new loci under...
Podoconiosis is a tropical lymphedema resulting from long-term barefoot exposure to red-clay soil derived volcanic rock. The World Health Organization recently designated it as neglected disease. develops in only subgroup of exposed people, and studies have shown familial clustering with high heritability (63%).
<h3>Importance</h3> Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, efficacy lithium varies widely, with nonresponse rate up to 30%. Biological response markers are lacking. Genetic factors thought mediate lithium, and there previously reported genetic overlap between BPAD schizophrenia (SCZ). <h3>Objectives</h3> To test whether polygenic score SCZ associated in explore potential molecular underpinnings this association. <h3>Design,...
<h3>Importance</h3> Prenatal exposure to persistent organic pollutants (POPs) has been associated with birth size, but data on fetal growth and among racially/ethnically diverse pregnant women remain scarce. <h3>Objectives</h3> To assess the association between maternal plasma POPs in early pregnancy by infant sex race/ethnicity. <h3>Design, Setting, Participants</h3> This cohort study used National Institute of Child Health Human Development Fetal Growth Studies–Singleton cohort, which...
Persistent organic pollutants (POPs) are linked with insulin resistance and type-2 diabetes (T2D) in the general population. However, their associations gestational (GDM) inconsistent. We prospectively evaluated of POPs measured early pregnancy GDM risk. also assessed whether pre-pregnancy BMI (ppBMI) family history T2D modify this In NICHD Fetal Growth Study, Singletons, we plasma concentration 76 POPs, including 11 organochlorine pesticides (OCPs), 9 polybrominated diphenylethers (PBDEs),...
Dysregulation of maternal glucose homeostasis has been related to an increased risk morbidity and mortality in mothers fetuses, yet the mechanism remains unclear. This study investigated association between glycemic levels placental epigenetic age acceleration (PAA) a multiethnic cohort. In sample 301 pregnant women (102 Hispanic, 77 White, 72 Black, 50 Asian/Pacific Islander), markers cumulative exposure with PAA was tested using linear regression adjusting for fetal sex, age, educational...
Summary Background Endemic non‐filarial elephantiasis or podoconiosis is a chronic and debilitating geochemical disease occurring in individuals exposed to red clay soil derived from alkalic volcanic rock. It major public health problem countries tropical Africa, Central America North India. Objective To estimate the direct average productivity cost attributable podoconiosis, compare time of patients with non‐patients. Methods Matched comparative cross sectional survey involving 702 study...
Currently there is increasing recognition of the need for research in developing countries where disease burden high. Understanding role local factors important undertaking ethical countries. We explored relating to information and communication during process informed consent, approach that should be followed gaining consent. The study was conducted prior a family-based genetic among people with podoconiosis (non-filarial elephantiasis) southern Ethiopia.We adapted method rapid assessment...
The consent process for a genetic study is challenging when the research conducted in group stigmatized because of beliefs that disease familial. Podoconiosis, also known as 'mossy foot', an example such disease. It condition resulting swelling lower legs among people exposed to red clay soil. very stigmatizing problem endemic areas Ethiopia widely held opinion runs families and untreatable. aim this was explore impact social stigma on obtaining genetics podoconiosis Southern Ethiopia. We...
Translation of genomic discoveries into patient care is slowly becoming a reality in developed economies around the world. In contrast, low- and middle-income countries (LMIC) have participated minimally research for several reasons including lack coherent national policies, limited number well-trained scientists, poor infrastructure, local economic cultural challenges. Recent initiatives such as Human Heredity Health Africa (H3Africa), Qatar Genome Project, Mexico National Institute Genomic...
Background Podoconiosis is an environmental lymphoedema affecting people living and working barefoot on irritant red clay soil. relatively well described in southern Ethiopia, but remains neglected other parts of the Ethiopian highlands. This study aimed to assess burden podoconiosis rural communities western Ethiopia. Methodology/Principal Findings A cross-sectional was conducted Gulliso woreda (district), west household survey 26 kebeles (villages) this district identify patients measure...
Abstract Background Prenatal maternal plasma persistent organic pollutant (POP) concentrations have been associated with neonatal outcomes. However, the underlying mechanisms remain unknown. Placental epigenetic may be involved, but no prior epigenome-wide studies investigated impact of POPs on placental DNA methylation. We studied association between POP concentration in early pregnancy and methylation among 260 pregnant women from NICHD Fetal Growth Studies. Results Our analysis focused...
Identifying factors that influence fetal growth in a sex-specific manner can help unravel mechanisms explain sex differences adverse neonatal outcomes and in-utero origins of cardiovascular disease disparities.Premature aging the placenta, tissue supports exhibits epigenetic changes, is associated with pregnancy complications.Using DNA methylation-based age estimator, we investigated relationship placental across 13-40 weeks gestation, size, risk low birth weight.Placental acceleration...
The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important ensure equitable health care benefit from research advances. Here, members the Ethical, Legal, Social, Implications (ELSI) committee International Genetic Epidemiology Society (IGES) offer perspectives on methods analysis tools for conduct inclusive epidemiology research, with a focus admixed populations support reproducible practices. We emphasize importance distinguishing...
Abstract Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health that affects about 1% of population worldwide. Nevertheless, lithium not consistently effective, with only 30% patients showing favorable response to treatment. To provide personalized options patients, it essential identify prediction biomarkers such polygenic scores. In this study, we developed score (Li + PGS ) in BD. gain further insights into lithium’s possible...
To develop and test a robust clinical staging system for podoconiosis, geochemical disease in individuals exposed to red clay soil.
We investigated ancestry of 3,528 modern humans from 163 samples. identified 19 ancestral components, with 94.4% individuals showing mixed ancestry. After using whole genome sequences to correct for ascertainment biases in genome-wide genotype data, we dated the oldest divergence event 140,000 years ago. detected an Out-of-Africa migration 100,000–87,000 ago, leading peoples Americas, east and north Asia Oceania, followed by another 61,000–44,000 Caucasus, Europe, Middle East south Asia....
Genome wide association studies (GWAS) for type 2 diabetes (T2D) undertaken in European and Asian ancestry populations have yielded dozens of robustly associated loci. However, the genomics T2D remains largely understudied sub-Saharan Africa (SSA), where rates are increasing dramatically environmental background is quite different than these previous studies. Here, we evaluate 106 reported GWAS loci continental Africans. We tested each SNPs, SNPs linkage disequilibrium (LD) with index an...