A5070621439- Bipolar Disorder and Treatment
- HIV/AIDS Research and Interventions
- Phytochemistry Medicinal Plant Applications
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Ethnobotanical and Medicinal Plants Studies
- HIV Research and Treatment
- Medicinal Plant Extracts Effects
- Cholinesterase and Neurodegenerative Diseases
- Childhood Cancer Survivors' Quality of Life
- Phytochemistry and biological activity of medicinal plants
- Mental Health Research Topics
- Cytomegalovirus and herpesvirus research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Healthcare Regulation
- Nuclear Receptors and Signaling
- Adolescent and Pediatric Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Plant Toxicity and Pharmacological Properties
- Genetics and Neurodevelopmental Disorders
- AI in cancer detection
- HIV-related health complications and treatments
Inserm
2016-2022
Inserm Transfert
2022
Université Paris Cité
2016-2018
Délégation Paris 5
2016-2018
Sorbonne Paris Cité
2016-2018
Délégation Paris 7
2016
Universidade do Extremo Sul Catarinense
2008-2013
Centro Universitário do Espírito Santo
2009-2013
Universidade do Vale do Itajaí
2013
Universidade Federal do Rio Grande do Norte
2011
Bipolar disorder (BD) is a severe and common psychiatric disorder. BD pathogenesis, clinical manifestations relapses are associated with numerous circadian rhythm abnormalities. Lithium (Li) the first-line treatment in BD, its therapeutic action has been related to ability alter rhythms. We systematically searched PubMed database until January 2016, aiming critically examine published studies investigating direct indirect effects of Li on The results, from 95 retained studies, indicated that...
Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-D-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in ethno-medicines tropical subtropical countries.This study was designed evaluate the anti-hyperalgesic activity of corilagin using chemically thermally based nociception models mice.Corilagin (Euphorbiaceae) by extraction chromatographic...
Objectives: We examine whether the lithium response is associated with changes in expression of core clock genes.Methods: The effect a therapeutic concentration (1 mM) on levels 17 circadian genes was examined lymphoblastoid cell lines (LCLs) derived from two well-characterized groups bipolar disorder patients, defined as non-responders (NR, n = 20) or excellent responders (ER, 16). Quantitative real-time PCR (qRT-PCR) conducted at 2, 4 and 8 days (d2, d4 d8) without exposure.Results: At d2,...
Melissa officinalis (L.) (Lamiaceae), a plant known as the lemon balm, is native to east Mediterranean region and west Asia. Also found in tropical countries, such Brazil, where it popularly "erva-cidreira" or "melissa", widely used aqueous- alcoholic-extract form treatment of various disorders. The aim was investigate vivo its antigenotoxicity antimutagenicity, well genotoxic/mutagenic potential through comet micronucleus assaying. CF-1 male mice were treated with ethanolic (Mo-EE) (250 500...
The correct use of plants for therapeutic purposes requires selection those showing efficacy and safety based on the popular tradition and/or scientific validation. Bidens pilosa L. is a species that widely occurs in tropical regions known Brazil as "picão-preto". Four agents from Health Pastoral Service were identified region Criciuma, Santa Catarina State, their knowledge pilosa. study was conducted by means interview which provided data concerning "picão preto", handling, used plant part,...
MMP polymorphisms in COPD patients significant impact on
Southern Brazil has the highest prevalence rate of AIDS in country and is only region Americas where HIV-1 subtype C prevails. We evaluated epidemiologic clinical characteristics pregnant women living with HIV/AIDS South Santa Catarina, Brazil. All HIV infection attending obstetric outpatient clinic Criciúma, State 2007 (n = 46) were invited to participate. Data 36 eligible participants obtained through a standardized questionnaire. The great majority young, steady partner, low family...
Southern Brazil has the highest prevalence rate of AIDS in country and is only region Americas where HIV-1 subtype C prevails. OBJECTIVE: We evaluated epidemiologic clinical characteristics pregnant women living with HIV/AIDS South Santa Catarina, Brazil. METHODS: All HIV infection attending obstetric outpatient clinic Criciúma, State 2007 (n = 46) were invited to participate. Data 36 eligible participants obtained through a standardized questionnaire. RESULTS: The great majority young,...
Medicinal plants are still widely used worldwide; yet for some species, little or no information is available concerning their biological activity, specially genotoxic and antimutagenic potential. Mikania laevigata (Asteraceae) a native plant from South America, its extracts largely to treat respiratory complaints. The aim of the present work was then evaluate, in vivo, potential activity M. on genotoxicity induced by methyl methanesulfonate (MMS) cyclophosphamide (CP), using comet assay....
Objectives: Lithium is the leading mood stabiliser for maintenance treatment in bipolar disorder (BD). However, response to lithium heterogeneous with more than 60% of patients experiencing partial or no response. In vitro and vivo molecular studies have reported implication kinases pathophysiology BD.Methods: Since are putative targets therapeutic action, we conducted first pilot study using kinase array technology evaluate global serine/threonine (STK) profiles cell lines from BD I subtype...
e18506 Background: In the last two decades, new therapeutic options have emerged to complement traditional intensive chemotherapy (IC) regimens in treatment of Acute myeloid leukemia (AML). Hypomethylating agents (HMAs), B-cell lymphoma 2 (BCL-2) protein inhibitor Venetoclax, and other targeted therapies are examples. Guideline-based decisions intricate, considering both patient fitness IC disease characteristics. AML real-word studies on patterns typically focus specific subpopulations...
A utilização de plantas medicinais é notória, entretanto, nem todas possuem ações terapêuticas cientificamente comprovadas. Este artigo resultado um levantamento bibliográfico sobre duas árvores presentes no Parque Ecológico Municipal José Milanese (PEMJM), localizado Bairro Mina União, município Criciúma, Santa Catarina e utilizadas pela população local por apresentarem efeitos terapêuticos. Trata-se uma revisão cunho científico os terapêuticos apontados comunidade posteriormente...