A5062030832- Alkaloids: synthesis and pharmacology
- Natural Compound Pharmacology Studies
- Chemical synthesis and alkaloids
- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Synthesis of Organic Compounds
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Medicinal Plants and Neuroprotection
- Advances in Cucurbitaceae Research
- Helicobacter pylori-related gastroenterology studies
- Analytical Chemistry and Chromatography
- Synthesis and bioactivity of alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Bioactive Compounds and Antitumor Agents
- Microbial Metabolites in Food Biotechnology
- Psidium guajava Extracts and Applications
- Polysaccharides and Plant Cell Walls
- Piperaceae Chemical and Biological Studies
- Phytochemistry and Bioactivity Studies
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Phytochemistry and Bioactive Compounds
- Cancer Treatment and Pharmacology
Universidade do Vale do Itajaí
2014-2025
Instituto de Infectologia Emílio Ribas
2024
Universidade Federal do Rio Grande do Sul
2013-2022
Vrije Universiteit Brussel
2015-2020
Instituto de Ciências Farmacêuticas
2020
Universidade Federal do Rio Grande
2016
Universidade Feevale
2013
City Of Hope National Medical Center
1980-1981
Herbal medicines are important options for the treatment of several illnesses. Although their therapeutic applicability has been demonstrated throughout history, concerns about safety and efficacy raised regularly. Quality control articles botanical origin, including plant materials, extracts, herbal medicines, remains a challenge. Traditionally, qualitative (e.g., identification chromatographic profile) quantitative content analyses) markers applied this purpose. The compound-oriented...
Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-D-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in ethno-medicines tropical subtropical countries.This study was designed evaluate the anti-hyperalgesic activity of corilagin using chemically thermally based nociception models mice.Corilagin (Euphorbiaceae) by extraction chromatographic...
Abstract Objectives The purpose of this study was to assess the gastroprotective properties methanol extract and diterpene marrubiin obtained from leaves M. vulgare. Methods Assays were performed using different protocols in mice. Studies focusing on mechanisms gastroprotection also undertaken. Key findings In model ethanol-induced ulcers, we observed a significant reduction all parameters analysed; curative ratios 49.31 ± 0.57, 74.31 0.91 79.86 0.59 for groups treated with 50 100 mg/kg...
Brassica oleracea var. acephala DC has been extensively used in Brazilian traditional medicine to treat gastric ulcer.This study was conducted evaluate the antiulcerogenic property of hydroalcoholic extract obtained from leaves oleracea.Antiulcer assays were performed using protocol ulcer induced by ethanol/HCl, and non-steroidal anti-inflammatory drugs (NSAIDs). Parameters secretion (volume, pH [H(+)]) determined pylorus ligation model mucus contents.In ethanol-induced model, we observed a...
Garcinia cambogia seems to promote weight reduction and improvement on lipid profile by its major compound, hydroxycitric acid (HCA), blocking ATP-citratelyase, potentially inhibiting lipogenesis. Furthermore, it is suggested that extract able change the adipokine levels. Thus, aim of this study was analyse effect G. profile, endocrine, calorimetric anthropometric parameters obese women. The women (BMI > 25 kg/m(2) ; age 25-60 years), divided in treated (n = 30) control 13) groups, received...
Indole alkaloids and synthetic indole derivatives are well known for their therapeutic importance. In fact, preclinical clinical studies had already demonstrated several pharmacological activities these compounds. Here, we overview the multifunctional potential of molecules inhibition enzymes related to neurodegenerative disease: acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidases A B (MAO-A MAO-B). focus will be given on Psychotria L. genus, considering its...
Phytochemical investigation of the alkaloid extract Palicourea sessilis by LC-HRMS/MS using molecular networking and an in silico MS/MS fragmentation approach suggested presence several new monoterpene indole alkaloids. These compounds were isolated semipreparative HPLC, their structures confirmed means HRMS, NMR, ECD measurements as 4-N-methyllyaloside (3), 4-N-methyl-3,4-dehydrostrictosidine (4), 4β-hydroxyisodolichantoside (6), 4α-hydroxyisodolichantoside (7), well known alkaloids alline...
Phytochemical investigation of the alkaloid extract aerial parts Psychotria nemorosa led to isolation and characterization 10 azepine-indole alkaloids, i.e., cimitrypazepine (1), fargesine (2), nemorosines A (3), B (12), nemorosinosides A–F (4–9), as well two β-carboline derivatives, 10-hydroxyisodolichantoside (10) 10-hydroxydolichantoside (11), an isoxazole alkaloid, nemorosinoside G (13), serotonin (14), bufotenine (15), (S)-gentianol (16). Compounds 3–13 have not yet been described....
Introdução: O manejo cirúrgico do Trauma Cranioencefálico Grave em crianças envolve abordagens específicas para minimizar danos e promover a recuperação. A avaliação inicial é crucial deve incluir realização de exames imagem determinar gravidade o tipo lesão. As intervenções cirúrgicas geralmente visam descompressão craniana, remoção hematomas ou correção fraturas. escolha procedimento depende da apresentação clínica condição neurológica criança. acompanhamento pós-operatório essencial...
Calophyllum brasiliense is employed in folk medicine as an analgesic and to treat inflammation. This study aimed evaluate the anti-inflammatory effect of C. leaves' methanol extract, fractions, isolated compound amentoflavone. In vitro fMLP-induced neutrophil chemotaxis LPS-induced inflammatory mediator levels were assessed neutrophils or macrophages treated not with different concentrations its fractions Their effects on inflammation resolution was by evaluating efferocytosis. The extract...