A5020523131- Bipolar Disorder and Treatment
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Schizophrenia research and treatment
- Treatment of Major Depression
- Electrolyte and hormonal disorders
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Attention Deficit Hyperactivity Disorder
- Cognitive Abilities and Testing
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Fetal and Pediatric Neurological Disorders
- Adolescent and Pediatric Healthcare
- Child Abuse and Trauma
- Child and Adolescent Health
- Stress Responses and Cortisol
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Infectious Encephalopathies and Encephalitis
- Psychosomatic Disorders and Their Treatments
University of British Columbia
2021-2024
British Columbia Children's Hospital
2022-2024
University of Milan
2024
University of British Columbia Hospital
2023
University of Toronto
2023
Hospital for Sick Children
2023
SickKids Foundation
2023
Women's Hospital
2023
Hôpital des Enfants
2023
McMaster University
2012-2022
To report the symptomatic and functional outcomes in patients with major depressive disorder (MDD) during a 2-phase treatment trial to estimate value of early improvement after 2 weeks predicting clinical response escitalopram subsequently adjunctive aripiprazole.Participants MDD (N = 211) identified Montgomery-Asberg Depression Rating Scale (MADRS) confirmed Mini-International Neuropsychiatric Interview were recruited from 6 outpatient centers across Canada (August 2013 through December...
Abstract Neuroimaging-based brain age is a biomarker that generated by machine learning (ML) predictions. The gap (BAG) typically defined as the difference between predicted and chronological age. Studies have consistently reported positive BAG in individuals with schizophrenia (SCZ). However, there little understanding of which specific factors drive ML-based predictions, leading to limited biological interpretations BAG. We gathered data from three publicly available databases - COBRE,...
In vivo imaging studies have suggested anatomical and functional abnormalities in the anterior cingulate adults with mood disorders. This magnetic resonance study examined cortex children adolescents bipolar disorder matched healthy comparison subjects.Sixteen patients (mean age=15.5 years, SD=3.4) DSM-IV 21 subjects age=16.9 SD=3.8) were studied. Three-dimensional gradient echo was performed (TR=25 msec, TE=5 slice thickness=1.5 mm) a 1.5-T GE Signa magnet. Cingulate volumes compared by...
Objective We examined the relationship between biological rhythms and severity of depressive symptoms in subjects with bipolar disorder effects alterations on functional impairment. Method Bipolar patients ( n = 260) healthy controls 191) were recruited from mood disorders programs three sites (Spain, Brazil, Canada). Parameters measured using Biological Rhythms Assessment Neuropsychiatry BRIAN ), an interviewer administered questionnaire that assesses disruptions sleep, eating patterns,...
Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined an interaction model predicting negative emotionality first 3 years. In 179 mother-infant dyads from Maternal Adversity, Vulnerability, Neurodevelopment cohort, prenatal (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The score consisted number alleles serotonin transporter linked polymorphic region gene (5-HTTLPR): no...
Disruptions in biological rhythms and sleep are a core aspect of mood disorders, with rhythm changes frequently occurring prior to during episodes. Wrist-worn actigraphs increasingly utilized measure ambulatory activity patterns.A comprehensive study using subjective objective measures was conducted 111 participants (40 healthy volunteers [HC], 38 major depressive disorder [MDD] 33 bipolar [BD]). Participants completed 15-day actigraphy first-morning urine samples 6-sulfatoxymelatonin...
Abstract Background The proportion of Canadian youth seeking mental health support from an emergency department (ED) has risen in recent years. As EDs typically address urgent crises, revisiting ED may represent unmet needs. Accurate revisit prediction could aid early intervention and ensure efficient healthcare resource allocation. We examine the potential increased accuracy performance graph neural network (GNN) machine learning models compared to recurrent (RNN), baseline conventional...