Topics in Obstetrics & Gynecology 42(14):p 7-8, September 30, 2022. | DOI: 10.1097/01.PGO.0000873452.09562.77

Abstract Aims To examine the association between gestational diabetes mellitus ( GDM ) and high maternal weight risk of development chronic disease. Methods Women with singleton deliveries April 1999 March 2010 in Alberta, Canada, were categorized according to pre‐pregnancy (overweight ≥ 91 kg) status. Obstetric neonatal outcomes, as well long‐term incidence diabetes, hypertension cardiovascular disease examined. Results Of 240 083 women, 213 765 (89%) had no not overweight (reference...

Phenylephrine is known to stimulate translocation of protein kinase C in rat pinealocytes (Sugden, D., Vanecek, J., Klein, D.C., Thomas, T.P., and Anderson, W. B. (1985) Nature 314, 359-361). In the present study, receptor mediating this effect was found belong alpha 1-adrenoceptor subclass. Activation also produce a sustained increase [Ca2+]i by increasing net influx A. L., Sugden, D. C. J. Biol. Chem. 261, 11608-11612), which points possible importance Ca2+ subcellular redistribution...

OBJECTIVE Depressive symptoms are common and, when coexisting with diabetes, worsen outcomes and increase health care costs. We evaluated a nurse case-manager–based collaborative primary team model to improve depressive in diabetic patients. RESEARCH DESIGN AND METHODS conducted controlled implementation trial four nonmetropolitan networks. Eligible patients had type 2 diabetes screened positive for symptoms, based on Patient Health Questionnaire (PHQ) score of ≥10. Patients were allocated...

To determine the rate of adherence to postpartum glycemic testing in women with gestational diabetes mellitus (GDM) and performance fasting plasma glucose (FPG) versus 75-g oral tolerance test (OGTT) detecting intolerance.The study was a retrospective cohort 1,006 GDM attending pregnancy clinic.Postpartum screening completed 438 (48%) women. Women nonadherent had higher parity (1.10 vs. 0.87) were less likely require insulin for management their GDM. Among who tested, 89 (21%) an abnormal...

In the present study role of protein kinase C in adrenergic stimulation cGMP was reinvestigated, with purpose determining whether activators would potentiate effects &adrenergic agonists on if cells were also treated agents known to elevate intracellular free Ca2+.The activator 4&phorbollZ-myristate 13-acetate (PMA) markedly elevated content &adrenergically stimulated pinealocytes which had been 1 PM A23187, 15 mM K+, or M ouabain.The A23187 blocked by EGTA and those K+ nifedipine,...

Abstract Background Although allergic reactions to insulin are uncommon, they can be difficult diagnose and management may very in subjects with Type 1 diabetes severe allergy. Access allergists specialist diagnostic tests is limited few specialists familiar desensitization as a means of treating People develop symptoms which mimic allergy but attributable other conditions. Case reports Here we describe three cases One patient presented severe, albeit localized, urticarial at injection...

Objective: To evaluate reproductive function in patients with cystinosis and renal transplant recipients without cystinosis. Design: Cross-sectional study. Setting: Clinical Center, National Institutes of Health. Patients: Ten male patients, 15 to 28 years old, nephropathic allografts formed the study group; 11 who had a primary disorder other than were matched for age served as control group. Measurements: Tanner staging, serum gonadotropin determinations, testosterone testosterone-binding...

The mechanism by which GH-releasing peptides elicit GH secretion has remained largely unknown. In this study, the effects of a second generation peptide, Ala-His-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2(GHRP-1), on cAMP, intracellular Ca2+ ([Ca2+]i), and release were examined using rat pituitary gland static monolayer cell cultures. It was found that GHRP-1 increased in dose-dependent manner up to 3-fold, while having no effect cAMP levels. contrast, simultaneous elevations observed after treatment...

Journal Article Hyperprolactinemia caused by lactation and pituitary adenomas is associated with altered serum calcium, phosphate, parathyroid hormone (PTH), PTH-related peptide levels Get access C S Kovacs, Kovacs 1Department of Medicine, University Alberta, Edmonton, Canada. Search for other works this author on: Oxford Academic Google Scholar L Chik The Clinical Endocrinology & Metabolism, Volume 80, Issue 10, 1 October 1995, Pages 3036–3042, https://doi.org/10.1210/jcem.80.10.7559893...

alpha 1-Adrenergic agonists have recently been found to potentiate vasoactive intestinal peptide (VIP) stimulation of rat pinealocyte cAMP and cGMP. also elevate pineal intracellular Ca2+ [( Ca2+]i) activate protein kinase-C. In the present study, possible involvement kinase-C in 1-adrenergic potentiation VIP-stimulated cGMP accumulation was examined with agents that alter [Ca2+]i or It treatment a chelator inorganic channel blockers inhibited responses. Increasing by A23187, ouabain, K+...

To evaluate demographic data and quality of care patients with acromegaly in Canada their evolution over time secondly, to predictors co-morbidities treatment outcomes.Retrospective analyses clinical, biochemical outcome 649 (males: 50·7%) followed from 1980 2010 (mean 10·2 years, SD 13·7) eight tertiary centres six Canadian provinces.In comparison 1980-1994, the number referred last 15 years was higher female preponderance (52·8% vs 41·4%, P = 0·01) an older age at diagnosis (46·4 ± 14 41·3...

When depression accompanies diabetes, it complicates treatment, portends worse outcomes and increases health care costs. A collaborative case-management model, previously tested in an urban managed organization the US, achieved significant reduction of depressive symptoms, improved diabetes disease control patient-reported outcomes, saved money. While impressive, these findings need to be replicated extended other healthcare settings. Our objective is comprehensively evaluate a model for...

Examine, in a real-world setting, whether strict normalization of modestly elevated insulin-like growth factor 1 (IGF1) results clinical and health-related quality life benefits patients with acromegaly using an open-label, non-randomized, 6-month prospective interventional study. In modest IGF1 elevation, control was achieved by addition or dose escalation pegvisomant. Clinical biochemical parameters were assessed at baseline, 3 months for pegvisomant titration, 6 months. The...

We describe the changes in calcium homeostasis seen a hypoparathyroid woman during third trimester and with lactation following her second pregnancy. During need for supplemental calcitriol abated, fact she was transiently hypercalcemic hypophosphatemic. This change associated rise of serum parathyroid hormone-related peptide (PTHrP) released systemically lactation. is first documentation time course PTHrP levels from late throughout woman. In this context may have sufficient biological...

Abstract. Food restriction (50%) effects on the 24-h rhythm of serum and pineal melatonin (MT) were studied in 260–300 g male Wistar rats under a lighting regimen 14 h light 10 dark. Body weight, testicular accessory organ weights, LH, testosterone, rhythms MT determined. One week food caused decrease body weight (18%), weights LH (50%), but had no effect or MT. Three weeks suppressed further (35% 39%, respectively), reduced (68%) testosterone (53%), (12%) raised (34%). The increased may...

Background The risk and mortality due to cancer in patients with acromegaly have been previously investigated. Although GH/IGF-1 excess provides a probable pathophysiological explanation, the degree of IGF-1 role acromegaly-associated neoplasms diabetes, common comorbidity known association cancer, remains unclear. Methods Acromegalic treated three Canadian referral centers (Toronto, Montreal, Edmonton) were included. All available clinical information was recorded including: age, initial...

Tumors of hypothalamic neurons that produce vasopressin are rare. We retrieved all cases vasopressin-positive tumors in the sellar region from database Department Pathology. Five fulfilled selection criteria, representing first series such tumors. Clinical, radiologic, and pathologic features were reviewed. Four classified as neurocytomas identified 3 females 1 male patient; ages at onset symptoms ranged 17 to 40 years. All large masses with suprasellar extension and/or invasion parasellar...