A5008143523- Renal cell carcinoma treatment
- Renal and related cancers
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Chromatin Remodeling and Cancer
- Prostate Cancer Treatment and Research
- Genital Health and Disease
- Testicular diseases and treatments
- Cellular transport and secretion
- Tuberous Sclerosis Complex Research
- Salivary Gland Tumors Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Pediatric Urology and Nephrology Studies
- Urological Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Infectious Disease Case Reports and Treatments
- Cardiac tumors and thrombi
- Enzyme function and inhibition
- Biomarkers in Disease Mechanisms
Western General Hospital
2013-2024
Birmingham Women’s and Children’s NHS Foundation Trust
2020-2024
NHS Lothian
2014-2021
Edinburgh Cancer Research
2012-2015
University Hospitals of Morecambe Bay NHS Foundation Trust
2015
University of Edinburgh
1995-2014
Institute of Cancer Research
2013
Queen Mary University of London
2013
Guy's and St Thomas' NHS Foundation Trust
2012
Beatson West of Scotland Cancer Centre
2012
Highlights•Anti-CTLA-4 of hIgG1 and hIgG2 isotypes promote depletion intra-tumoral Treg cells•hIgG2 antibodies mediate in vivo cells via CD32a•Anti-CTLA-4 with enhanced Fc effector function improves therapeutic outcomes•The CD16-V158F SNP is associated response to ipilimumab inflamed tumorsSummaryWith the use a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that equivalent tremelimumab regulatory T (Treg) cell vivo, increasing CD8+ ratio promoting tumor rejection....
Concern about possible false-negative prostate biopsy histopathology findings often leads to rebiopsy. A quantitative methylation specific polymerase chain reaction assay panel, including GSTP1, APC and RASSF1, could increase the sensitivity of detecting cancer over that pathological review alone, leading a high negative predictive value decrease in unnecessary repeat biopsies.The MATLOC study blindly tested archived needle core tissue samples 498 subjects from United Kingdom Belgium with...
Abstract Background Surgery for renal cell carcinoma (RCC) with venous tumour thrombus (VTT) extension into the vein (RV) and/or inferior vena cava (IVC) has high peri-surgical morbidity/mortality. NAXIVA assessed response of VTT to axitinib, a potent tyrosine kinase inhibitor. Methods was single-arm, multi-centre, Phase 2 study. In total, 20 patients resectable clear RCC and received upto 8 weeks pre-surgical axitinib. The primary endpoint percentage evaluable improvement by Mayo level on...
Abstract The calcium‐binding protein S100A4 induces the metastatic phenotype in rodent models of breast cancer and its expression correlates strongly with reduced survival human cancer. normal bladders 101 bladder tumours has been studied using immunocytochemistry. Moderate or strong was found 28% tumours, whilst remaining urothelium either failed to stain showed weak staining. staining more frequently observed invasive than non‐invasive ( p <0.05). In usually strongest regions single...
To investigate how biologically relevant markers change in response to antiangiogenic therapy metastatic clear cell renal cancer (mRCC) and correlate these changes with outcome.The study used sequential tumor tissue functional imaging (taken at baseline 12-16 weeks) obtained from three similar phase II studies. All studies investigated the role of VEGF tyrosine kinase inhibitors (TKI) before planned nephrectomy untreated mRCC (n = 85). The effect targeted on ten biomarkers was measured...
The histopathological diagnosis of chromophobe renal cell carcinoma can present a diagnostic challenge, as these tumours resemble either conventional or oncocytoma. aim this study was to determine whether cytokeratin 7 expression is practical use in the distinction three entities.A total 40 cases previously diagnosed carcinoma, oncocytoma were identified. A representative section each stained with H&E and 7. Following independent review by pathologists, consensus for case reached pattern...
Vascular endothelial growth factor (VEGF) mediates neo-angiogenesis during tumour progression and is known to cooperate with the fibroblast (FGF) system facilitate angiogenesis in a synergistic manner. In view of this, we have investigated VEGF expression 67 cases prostate cancer previously characterized for factor-8 (FGF-8) expression. Cytoplasmic staining was detected malignant cells 45 out cases. found adjacent stromal 32 cases, being particularly strong around nests invasive tumour....
Abstract The extracellular matrix comprises a network of macromolecules such as collagens, proteoglycans and glycoproteins. VWA1 (von Willebrand factor A domain containing 1) encodes component the that interacts with perlecan/collagen VI, appears to be involved in stabilizing structures, demonstrates high expression levels tibial nerve. Vwa1-deficient mice manifest abnormal peripheral nerve structure/function; however, variants have not previously been associated human disease. By...
Abstract Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. With high mutation load large number of altered genes, strategies to delineate key driver events are necessary. Dogs cats develop urothelial carcinoma (UC) histological clinical similarities human MIBC. Cattle that graze on bracken fern also UC, exposure the carcinogen ptaquiloside. These species may represent relevant animal models spontaneous carcinogen-induced UC...
The accumulation of chloroquine and hydroxychloroquine in unfractionated mononuclear cells purified monocytes, lymphocytes, neutrophil polymorphonuclear leucocytes (PMN) was measured vitro. Accumulation both drugs time dose dependent. Cellular levels comparable to those found during antirheumatic therapy were achieved by preincubation for 60 minutes with up 0.1 mM or hydroxychloroquine.
Background and Aim During prostate development, mesenchymal-epithelial interactions regulate organ growth differentiation. In adult prostate, stromal-epithelial are important for tissue homeostasis also play a significant role in cancer. this study we have identified molecules that show mesenchymal expression pattern the developing one of these showed reduced cancer stroma. Methodology Principal Findings Five candidate by transcript profiling developmental mesenchyme were selected using...
Background: There is a lack of biomarkers to predict outcome with targeted therapy in metastatic clear cell renal cancer (mccRCC).This may be because dynamic molecular changes occur therapy.Objective: To explore if dynamic, targeted-therapy-driven correlate mccRCC outcome.Design, setting, and participants: Multiple frozen samples from primary tumours were taken sunitinib-naı ¨ve (n = 22) sunitinib-treated patients 23) for protein analysis.A cohort 86) paired, untreated...
Abstract Purpose: The aim of this study was to investigate the effect VEGF-targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental Design: Multiple tumor samples (n = 187 samples) were taken from primary tumors patients with mccRCC who sunitinib treated 23, SuMR clinical trial) or untreated SCOTRRCC study). ITH pathologic grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein...
Renal cell carcinoma (RCC) is the most deadly of urological malignancies. Metastatic disease affects one third patients at diagnosis with a further developing metastatic after extirpative surgery. Heterogeneity in clinical course ensures predicting metastasis notoriously difficult, despite routine use prognostic clinico-pathological parameters risk stratification. With greater understanding pathways involved pathogenesis, number biomarkers have been shown to significance, including Ki67,...
Abstract Purpose Paucity of reliable long-term data on the prognostic implications 2004 WHO bladder cancer classification system necessitates utilisation both this and 1973 grading systems. This study evaluated, in noninvasive (pTa) tumours, value independently combination with while establishing concordance between tertiary centre uropathologists. Methods We used a cohort non-muscle invasive (NMIBC) patients diagnosed 1991 93 where tumour features were gathered prospectively detailed...
This paper describes the pathological features of two cases composite extra‐renal rhabdoid tumor; that is, poorly differentiated carcinoma with extensive differentiation, arising in small intestine a 64‐year‐old man and pancreas 77‐year‐old woman. In both tumor behaved aggressively patients died from disseminated malignancy within 3 months original presentation diagnosis. To best our knowledge these are first examples such tumors pancreas.
Currently there is no curative treatment for metastatic clear cell renal cancer, the commonest variant of disease. A key factor in this resistance thought to be molecular complexity Targeted therapy such as tyrosine kinase inhibitor (TKI)-sunitinib have been utilized, but only 40% patients will respond, with overwhelming majority these relapsing within 1 year. As question intrinsic and acquired cancer highly relevant. In order study TKIs, ultimate goal developing effective, personalized...
Pathogenic variants in FLNA cause a diversity of X-linked developmental disorders associated with either preserved or diminished levels filamin A protein and are conceptualized dichotomously as relating to underlying gain- loss-of-function pathogenic mechanisms. Hemizygosity for germline deletions truncating is generally considered result embryonic lethality. Structurally, composed an N-terminal actin-binding region, followed by 24 immunoglobulin-like repeat units. The domains separated into...
We present the histology and electronmicroscopy of renal failure caused by ingestion mushroom species Cortinarius speciosissimus . Light microscopy revealed acute tubular necrosis, multinucleated epithelial cells concentric medial muscular hyperplasia arteries. Electronmicroscopy showed displaced abnormal architecture actin filaments at periphery cytoplasm in cells.
Pathological examination of a radical nephrectomy for papillary renal cell carcinoma showed tumour present within the perinephric fat, with morphology indicative iatrogenic tracking caused by previous biopsy mass. This is rare complication percutaneous biopsy, and as this procedure becoming more common in investigating masses, it important that professionals are aware potential risks posed mass biopsy.