A5005646680- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Testicular diseases and treatments
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- Vaccine Coverage and Hesitancy
- Sperm and Testicular Function
- COVID-19 and healthcare impacts
- Renal and related cancers
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Retinoids in leukemia and cellular processes
- Sarcoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Frailty in Older Adults
- Antioxidant Activity and Oxidative Stress
- Nutritional Studies and Diet
- Animal Disease Management and Epidemiology
- COVID-19 diagnosis using AI
- Urologic and reproductive health conditions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Bacterial Genetics and Biotechnology
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Arsenic contamination and mitigation
Mexican Social Security Institute
2019-2025
University of Monterrey
2021-2024
University of Edinburgh
2014-2015
Prolonged exposure to therapeutic doses of acetaminophen reduces testosterone production by human fetal testis xenografts in mice.
A few studies examined the comparative side effects of Coronavirus Disease-19 (COVID-19) vaccines. We compared extension and severity self-reported seven COVID-19 vaccines [BNT162b2 (Pfizer-BioNTech), ChAdOx1 (AstraZeneca), mRNA-1273 (Moderna), CoronaVac (Sinovac Life Sciences), Gam-COVID-Vac (Gamaleya's Sputnik V), Ad5-nCoV (CanSinoBIO), Ad26.CoV2.S (Johnson & Johnson/Janssen)] in Mexican population. also evaluated association type vaccine, sex, age, comorbidity, history allergies...
People with comorbidities and the male sex are at a higher risk of developing severe COVID-19. In present study, we aim to investigate associated factors for infection, severity, death due COVID-19 in population from Nuevo León, México. Epidemiological data were collected 65 hospitals December 2020 May 2022. A total 75,232 cases compiled which 25,722 positive SARS-CoV-2. Male sex, older age, diabetes, obesity, hypertension infection. addition above-mentioned factors, renal disease,...
Hepatocellular carcinoma (HCC) is among the main causes of death by cancer worldwide, representing about 80-90% all liver cancers. Treatments available for advanced HCC include atezolizumab, bevacizumab, sorafenib, others. Atezolizumab and bevacizumab are immunological options recently incorporated into first-line treatments, along with which great treatment achievements have been reached. However, sorafenib resistance developed in most patients, therapeutical combinations targeting hallmark...
Background/Objectives: Metabolic syndrome (MetS) is a predisposing factor for severe COVID-19. The effectiveness of COVID-19 vaccines in patients with MetS has been poorly investigated. aim this study was to evaluate the vaccination before (BO) and after Omicron (AO) SARS-CoV-2 variant MetS. Methods: This retrospective observational carried out total 3194 PCR or rapid antigen test. main outcomes were vaccine against infection, hospitalization death resulting from Results: BO, only two doses...
Abstract Background Testicular germ cell cancer (TGCC) develops from pre-malignant neoplasia in situ (GCNIS) cells. GCNIS originates fetal gonocytes (POU5F1 + /MAGE-A4 − ), which fail to differentiate pre-spermatogonia ) and undergo malignant transformation. Gankyrin is an oncogene has been shown prevent POU5F1 degradation specifically interact with MAGE-A4 hepatocellular carcinoma (HCC) We aimed investigate the role of progression gonocyte pre-invasive subsequent invasive TGCC. Methods...
Aquatic wild birds, especially waterfowl, have been long considered the main reservoirs of avian influenza A virus; however, recent surveys found an important prevalence these viruses among land birds as well. Migration has suggested factor in virus dissemination. We aimed to estimate (waterbirds and birds; resident migratory) eastern Mexico, where three North American migration flyways converge there was no previous information on this subject. detected with reverse transcription coupled a...
Abstract Background One of the risk factors for getting seriously ill from COVID-19 and reaching high mortality rates is older age. Older age also associated with comorbidities, which are severe infection. Among tools that have been evaluated to predict intensive care unit (ICU) admission ABC-GOALScl. Aim In present study we validated utility ABC-GOALScl in-hospital in subjects over 60 years who were positive SARS-CoV-2 virus at moment purpose optimizing sanitary resources offering...
The end of the coronavirus disease 2019 (COVID-19) pandemic has been declared by World Health Organization on May 5, 2023. Several vaccines were developed, and new data is being published about their effectiveness. However, clinical trials for performed before Omicron variant appeared there are population groups where vaccine effectiveness still needs to be tested. overarching goal present study was analyze effects COVID-19 vaccination after in patients considering comorbidities a from Nuevo...
A generation of induced pluripotent stem cells (iPSC) by ectopic expression OCT4, SOX2, KLF4, and c-MYC has established promising opportunities for cell research, drug discovery, disease modeling. While this forced genetic represents an advantage, there will always be issue with genomic instability transient pluripotency genes reactivation that might preclude their clinical application. During the reprogramming process, a somatic must undergo several epigenetic modifications to induce groups...
Abstract Background The generation of induced pluripotent stem cells has opened the field study for cell research, disease modeling and drug development. However, epigenetic signatures present in somatic make reprogramming still an inefficient process. This memory constitutes obstacle cellular reprogramming. Here, we report effect hydralazine (HYD) valproic acid (VPA), two small molecules with proven activity, on expression pluripotency genes adult (aHF) neonatal (nbHF) human fibroblasts....
COVID-19 vaccines' safety has been extensively studied; however, further analysis is required in pregnant women, nursing mothers, and breastfed infants. Our aim was to compare the extension severity of self-reported vaccine side effects breastfeeding In this cross-sectional study, COVID-19-vaccinated subjects were enrolled using an online survey Mexico. Women classified by pregnancy status at time vaccination (n = 3167). After first or only dose, there a trend toward fewer systemic women (p...
Information on Paxlovid™ effectiveness must be monitored and updated in real world scenarios. Our research question was what is the of adult patients with COVID-19? Therefore, we investigated reducing incidence pneumonia, hospitalization, mortality a cohort COVID-19 positive from northeast Mexico.
<title>Abstract</title> <bold>Objectives</bold>: We aim to describe the predisposing factors for COVID-19 pneumonia and in-hospital death as an outcome of in a Mexican aged cohort northeast Mexico. The use CCI predict mortality this population will also be investigated. <bold>Study design:</bold> A case-control study was performed total 356 records from patients 60 years old above. Records were collected November 2019 August 2022 reconverted hospital located Nuevo León, Mexico, which 332...
Hepatocellular carcinoma (HCC) is the most common form of liver cancer. The number cases increasing and trend for next few years not encouraging. HCC usually detected in advanced stages disease, pharmacological therapies are entirely effective. For this reason, it necessary to search new therapeutic options. objective work was evaluate effect drugs isotretinoin thalidomide on c-MYC expression cancer-related proteins an cellular model. measured using RT-qPCR western blot assays. In addition,...
Aging is commonly accompanied by increased cardiovascular risk and diet plays a crucial role in health condition. The aim of this study was to determine factors as predictors nutritional Mexican older adults. A cross-sectional on patients aged ≥60 years with affiliated medical unit Northeast Mexico performed from July December 2021. evaluations were using the Mini Nutritional Assessment (MNA) questionnaire. After multivariate analysis, identified independent malnutrition hypertriglyceridemia...
Arsenic is considered a worldwide pollutant that can be present in drinking water. exposure associated with various diseases, including cancer. Antioxidants as selenite and α-tocopherol-succinate have been shown to modulate arsenic toxic effects. Since changes STAT3 PSMD10 gene expression carcinogenesis, the aim of this study was evaluate effect co-treatments or on these genes, livers chronically exposed Syrian golden hamsters. Animals were divided into six groups: (i) control, (ii) treated...
Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)
Cytokeratin and desmin expression have been associated with Sertoli cell maturity the development of testicular germ cancer (TGCC). Thus, present study aimed to characterize these intermediate filaments in normal testis TGCC. were determined by immunohistochemistry immunofluorescence human fetal, adult tissue from patients pre-invasive neoplasia in-situ (GCNIS) or invasive Desmin was expressed cells fetal testis, proportion expressing significantly reduced second trimester, compared first...