A5051090045- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Pregnancy and Medication Impact
- Extracellular vesicles in disease
- COVID-19 Impact on Reproduction
- Reproductive Health and Technologies
- Endometriosis Research and Treatment
- Maternal and Perinatal Health Interventions
- Delphi Technique in Research
- Inflammatory Bowel Disease
- Renal and related cancers
- Maternal and fetal healthcare
- Hemoglobinopathies and Related Disorders
- Grief, Bereavement, and Mental Health
- MicroRNA in disease regulation
- Microscopic Colitis
- COVID-19 and healthcare impacts
- Ectopic Pregnancy Diagnosis and Management
- Frailty in Older Adults
- Testicular diseases and treatments
- Childhood Cancer Survivors' Quality of Life
- Intraperitoneal and Appendiceal Malignancies
MRC Centre for Reproductive Health
2019-2025
University of Edinburgh
2019-2025
Edinburgh Royal Infirmary
2025
Medical Research Council
2020-2024
Centre for Inflammation Research
2023-2024
The Queen's Medical Research Institute
2022-2024
Queen's Medical Centre
2019-2022
Royal Liverpool University Hospital
2015-2016
University of Liverpool
2015-2016
University Teaching Hospital
2015
Abstract STUDY QUESTION Twenty years after the inception of first fertility preservation programme for pre-pubertal boys, what are current international practices with regard to cryopreservation immature testicular tissue? SUMMARY ANSWER Worldwide, tissue has been cryopreserved from over 3000 boys under age 18 a variety malignant and non-malignant indications; there is variability in related eligibility, clinical assessment, storage, funding. WHAT IS KNOWN ALREADY For male patients receiving...
The coronavirus disease 2019 (COVID-19) pandemic is disrupting health services worldwide. We aimed to evaluate the provision of obstetrics and gynaecology in UK during acute phase COVID-19 pandemic.Interview-based national survey.Women's healthcare units National Health Service.Junior doctors gynaecology.Participants were interviewed by members Audit Research Obstetrics Gynaecology trainees' collaborative between 28 March 7 April 2020. used a quantitative analysis for closed-ended questions...
Objectives To explore local induction of labour pathways in the UK National Health Service to provide insight into current practice. Design survey. Setting Hospital maternity services all four nations UK. Sample Convenience sample 71 units. Methods An online cross-sectional survey was disseminated and completed via a national network obstetrics gynaecology specialist trainees (October 2021-March 2022). Results were analysed descriptively, with associations explored using Fisher’s Exact...
Abstract STUDY QUESTION Can a core outcome set be developed through global consensus to standardize selection, collection, comparison, and reporting in future male infertility trials? SUMMARY ANSWER A minimum dataset, known as ‘core set’, has been for randomized controlled trials (RCTs) systematic reviews evaluating potential interventions infertility. WHAT IS KNOWN ALREADY Numerous factors, including failure consider the perspectives of men with lived experiences or their partners when...
Abstract Background Testicular germ cell cancer (TGCC) develops from pre-malignant neoplasia in situ (GCNIS) cells. GCNIS originates fetal gonocytes (POU5F1 + /MAGE-A4 − ), which fail to differentiate pre-spermatogonia ) and undergo malignant transformation. Gankyrin is an oncogene has been shown prevent POU5F1 degradation specifically interact with MAGE-A4 hepatocellular carcinoma (HCC) We aimed investigate the role of progression gonocyte pre-invasive subsequent invasive TGCC. Methods...
Background Endometrial hyperplasia (EH) is a precusor lesion for endometrial cancer (EC), the commonest gynaecological malignancy in high-income countries. EH proliferation of glandular tissue, classified as either non-atypical (NEH) or, if cytological features are abnormal, atypical (AEH). The clinical significance AEH that patients face both high risk having occult EC and progression to untreated. Recommendations on care women with were introduced by United Kingdom–wide guidance (Green-top...
Introduction: Erythroblastic island (EBI) macrophages play an essential role in the production and maturation of vast numbers red blood cells (RBCs) that are produced throughout life. Their location within bone marrow makes it difficult to study cellular molecular interactions associated with their action so we have used vitro model EBI niche using derived from human induced pluripotent stem (hiPSCs). We previously demonstrated activation transcription factor KLF1 enhanced activity...
(1) Background: This study aims to establish the knowledge, attitudes and current behaviours towards female fertility preservation (FP) services amongst healthcare professionals (HCPs) in UK. (2) Methods: An online survey was advertised publicly on social media platform Instagram between 25 February 2021 11 March 2021. (3) Results: In total, 415 participants fulfilled inclusion criteria completed survey. The majority of HCPs discussed FP techniques either never 39.5% (n = 164), once a year...
Abstract Background Currently there are no established fertility preservation options for pre-pubertal boys facing cancer treatment. Granulocyte-colony stimulating factor (G-CSF) treatment has been proposed to be chemoprotective against spermatogonial cell loss in an alkylating chemotherapy model of busulfan treated adult mice. Having previously shown that exposure the alkylating-like cisplatin resulted a reduction germ numbers immature human testicular tissues, we here investigate whether...
Various physician- and patient-reported instruments exist for quantification of disease activity in inflammatory bowel diseases (IBD) but none are widely used routine clinical practice. A simple outcome measure might help inform decision making. We evaluated a 0 to 10 score IBD (IBD-10) by correlation with conventional multicomponent indices.A single-center prospective cross-sectional study was conducted ambulant patients IBD. Patients were asked verbally rate the control Crohn's (CD) or...
Background Exposure to chemotherapy during childhood can impair future fertility. Studies using in vitro culture have shown exposure platinum-based alkylating-like reduces the germ cell number human fetal testicular tissues. We aimed determine whether effects of cisplatin on sub-populations are dependent gestational age fetus and what impact this might utility testis cultures model testis. Methods utilised an system pieces tissues (total n=23 fetuses) from three different groups (14-16...