A5076779270- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive biology and impacts on aquatic species
- Reproductive System and Pregnancy
- Sexual Differentiation and Disorders
- Animal Genetics and Reproduction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prenatal Screening and Diagnostics
- Hormonal and reproductive studies
- Urologic and reproductive health conditions
- Urological Disorders and Treatments
- Male Reproductive Health Studies
- Molecular Biology Techniques and Applications
- RNA Interference and Gene Delivery
- Effects and risks of endocrine disrupting chemicals
- Pluripotent Stem Cells Research
- Metabolism and Genetic Disorders
- Demographic Trends and Gender Preferences
- Birth, Development, and Health
- Animal testing and alternatives
- Reproductive Physiology in Livestock
- Ion channel regulation and function
University of Dundee
2016-2025
Ninewells Hospital
2016-2025
Center for Human Reproduction
2025
Unilever (United Kingdom)
2015-2024
University of Birmingham
2001-2022
University of the Philippines Manila
2022
World Health Organization
2022
Cornell University
2022
University of Münster
2022
Ministry of Health of the Russian Federation
2022
This article reports the results of most recent in a series EHSRE workshops designed to synthesize current state field Andrology and provide recommendations for future work (for details see Appendix). Its focus is on methods detecting sperm DNA damage potential application new knowledge about chromatin organization, vulnerability repair improve diagnosis treatment clinical infertility associated with that damage. Equally important use reliability these tests identify extent which...
Progesterone is present at micromolar concentrations in the cumulus matrix, which surrounds mammalian oocytes. Exposure of human spermatozoa to a concentration gradient progesterone (0-3 microM) simulate approach oocyte induced slowly developing increase [Ca(2+)](i) upon which, many cells, slow oscillations were superimposed. often started very low (<10 nm), and their frequency did not change during subsequent rise concentration. Oscillations also occurred, but much smaller proportion...
Summary. Peroxidative damage induced by reactive oxygen species (ROS) has been proposed as one of the major causes defective sperm function. In previous studies production ROS in semen, contribution contaminating leucocytes was not assessed. We determined levels 60 semen samples from men attending our infertility clinic and demonstrated performing extraction experiments with antibody-coated magnetic beads that, within this unselected population patients, were source low-density Percoll...
STUDY QUESTIONCan a tool be developed for authors, reviewers and editors of the ESHRE Journals to improve quality published studies which rely on semen analysis data?
Genomic imprinting is an epigenetic process in which allele-specific gene expression dependent on the parental inheritance. Although only a minority of human genes are imprinted, those that have been identified to date preferentially implicated prenatal growth and neurodevelopment. Mutations or epimutations imprinted control centres associated with disorders such as Angelman syndrome (AS) Beckwith–Wiedemann (BWS). Recently, increased frequency assisted reproductive technology (ART)...
There are many examples in assisted reproduction technology, where new technology and methods have been introduced into the clinical setting without appropriate development evidence-based medicine to show that procedure is safe beneficial patient. Examples include preimplantation genetic screening, hatching, vitro maturation, blastocyst transfer vitrification. Changes culture media composition, stimulation regimes laboratory protocols also often established internationally adequate...
Nitric oxide (NO) enhances human sperm motility and capacitation associated with increased protein phosphorylation. NO activates soluble guanylyl cyclase, but can also modify function covalently via S-nitrosylation of cysteine. Remarkably, this mechanism remains unexplored in although they depend on post-translational modification to achieve changes required for fertilisation. Our objective was identify targets sperm. Spermatozoa were incubated donors S-nitrosylated proteins identified using...
ESHRE has been running courses for basic semen analysis since 1994 and course material updated regularly in response to new findings publications. Following publication of the 5th edition WHO laboratory manual, entitled Laboratory Manual Examination Processing Human Semen (WHO5), Subcommittee training Special Interest Group Andrology evaluated potential amendments its course. In respect course, there are eight particular areas discourse that reviewed (i) maintaining four-class differential...
Abstract Background There is a global crisis in male reproductive health. Evidence comes from globally declining sperm counts and increasing system abnormalities, such as cryptorchidism, germ cell tumors, onset of puberty. Male factor infertility occurs ~40% couples experiencing infertility. Data demonstrate an association between overall Associated significant health conditions include diabetes mellitus, metabolic disorders, cardiovascular disease. Adding to the complexity that men...
STUDY QUESTIONWhat is the prevalence of defects in Ca2+-signalling pathways mediating hyperactivation (calcium influx and store mobilization) among donors sub-fertile patients are they functionally significant, i.e. related to fertilization success at IVF?
Abstract Background It is now 11 years since publication of the WHO 2010 guidelines for semen assessment values, and it critical to determine whether they are still valid and/or should be modified. Objectives To utilise data published combine these with used in provide an updated more comprehensive representation fertile man. This may utilised present distribution values use by 2021. Materials Methods Two specific analyses were performed namely, (1) Analysis 1: Examination following [termed...
Abstract BACKGROUND Intensive research on sperm ion channels has identified members of several channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance calcium potassium conductances for fertility. In species, current is carried by highly complex cation (CatSper). sperm, been conclusively shown to be a consisting pore forming subunit SLO3 auxiliary leucine-rich repeat-containing 52 (LRRC52). However, it controversial whether...