A5002868377- Effects and risks of endocrine disrupting chemicals
- Contact Dermatitis and Allergies
- Pesticide Exposure and Toxicity
- Animal testing and alternatives
- Chemical Safety and Risk Management
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Risk and Safety Analysis
- Inhalation and Respiratory Drug Delivery
- Carcinogens and Genotoxicity Assessment
- Cholinesterase and Neurodegenerative Diseases
- Drug-Induced Hepatotoxicity and Protection
- Chemistry and Chemical Engineering
- Indoor Air Quality and Microbial Exposure
- Agricultural safety and regulations
- Environmental Toxicology and Ecotoxicology
- Pesticide and Herbicide Environmental Studies
Procter & Gamble (United States)
2017-2023
Massachusetts Department of Environmental Protection
2000
The use of threshold toxicological concern (TTC) supports the safety assessment exposure to low levels chemicals when toxicity data are limited. Research Institute for Fragrance Materials (RIFM) delivers assessments fragrance materials that result in safe products consumer use. A major goal RIFM program is invest alternative methods animal testing materials. This includes TTC, which provides a pragmatic approach evaluation absence chemical-specific and reduces need generate new data. To...
The Threshold of Toxicological Concern (TTC) is an internationally accepted pragmatic and conservative tool for the safety assessment substances, which used in a wide range regulatory contexts. TTC approach produces human exposure threshold values (TTC values) originally derived by Munro from oral toxicity data on cancer non-cancer endpoints. This database has been recently substantially enlarged COSMOS database, enhanced dataset larger chemical domain, thereby resulting new, transparent...
A challenging step in human risk assessment of chemicals is the derivation safe thresholds. The Threshold Toxicological Concern (TTC) concept one option which can be used for safety evaluation substances with a limited toxicity dataset, but exposure sufficiently low. application TTC generally accepted orally or dermally exposed cosmetic ingredients; however, these values cannot directly applied to inhalation route because differences versus oral and dermal. Various approaches an have been...
The liver is the most common target organ in toxicology studies. development of chemical structural alerts for identifying hepatotoxicity will play an important role silico model prediction and help strengthen identification analogs used structure activity relationship (SAR)- based read-across. aim current study SAR-based expert-system decision tree screening hepatotoxicants across a wide range chemistry space proposed modes action clustering chemicals using defined core categories on...
Structure-activity relationship (SAR)-based read-across is an important and effective method to establish the safety of a data-poor target chemical (structure interest (SOI)) using hazard data from structurally similar source chemicals (analogues). Many methods use quantitative similarity scores evaluate structural for searching selecting analogues as well evaluating analogue suitability. However, studies suggest that based purely on cannot accurately predict toxicity SOI. As mechanistic...
A regional workgroup comprised of individuals from regulatory agencies, uni versities, and consulting companies was formed to develop an approach for incor porating information on chemical availability in soils into risk assessment based decision making. The consists the following framework including availability: (1) Determine usefulness incorporating bioavailability; (2) Identify needs a conceptual model exposure site pathways judged critical assessment; (3) soil factors that affect (4)...
The Threshold of Toxicological Concern (TTC) for non-genotoxic substances, a risk assessment tool to establish safe exposure levels chemicals with insufficient toxicological data, is based on the 5th percentile cumulated distributions Point Departures in high amount repeat-dose, developmental and reproductive toxicity studies, grouped by Cramer Classes. lack organosilicon compounds this dataset has resulted regulatory concerns over applicability TTC concept chemistry. We collected publicly...