A5044884305- Childhood Cancer Survivors' Quality of Life
- Reproductive Biology and Fertility
- Family Support in Illness
- Acute Lymphoblastic Leukemia research
- Adolescent and Pediatric Healthcare
- Reproductive Health and Technologies
- Renal and related cancers
- Ovarian function and disorders
- Sperm and Testicular Function
- Chemotherapy-induced cardiotoxicity and mitigation
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Cancer Risks and Factors
- Palliative Care and End-of-Life Issues
- Ovarian cancer diagnosis and treatment
- Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Family and Disability Support Research
- Economic and Financial Impacts of Cancer
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- PARP inhibition in cancer therapy
- Cancer survivorship and care
- Assisted Reproductive Technology and Twin Pregnancy
- Effects of Radiation Exposure
Children's Hospital of Philadelphia
2016-2025
University of Pennsylvania
2015-2025
Rutgers, The State University of New Jersey
2021
California University of Pennsylvania
2015-2019
University of Rochester Medical Center
2018
Harvard University
2018
University Medical Center Utrecht
2018
Cornell University
2018
Fred Hutch Cancer Center
2009-2016
St. Jude Children's Research Hospital
2009-2016
PURPOSE More than 90% of Ewing's sarcomas (ES) contain a fusion the EWS and FLI1 genes, due to t(11;22)(q24;q12) translocation. At molecular level, EWS-FLI1 rearrangements show great diversity. Specifically, many different combinations exons from encode in-frame transcripts result in differences length composition chimeric protein, which functions as an oncogenic aberrant transcription factor. In most common type (type 1), exon 7 is linked frame with 6 FLI1. As fundamental pathogenetic...
Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic alcohol metabolites. Polymorphisms in CBR1 and CBR3 influence synthesis these We examined whether single nucleotide polymorphisms (CBR1 1096G>A) and/or (CBR3 V244M) modified the dose-dependent risk anthracycline-related cardiomyopathy childhood cancer survivors.One hundred seventy survivors with (patient cases) were compared 317 no (controls; matched on diagnosis, year length follow-up, race/ethnicity) using...
PURPOSE The purpose of this study was to compare adolescent and young adult (AYA) pediatric cancer survivors peers without a history serious illness on psychological distress, health-related quality life (HRQOL), health beliefs; examine age at diagnosis treatment intensity these outcomes; relationships between number problems the outcomes. PATIENTS AND METHODS AYA (n = 167) controls 170), recruited during visits survivorship clinic primary care, completed self-report questionnaires problems,...
The development of endocrinopathies in survivors childhood cancer as they age remains understudied. We characterized endocrine outcomes aging from the Childhood Cancer Survivor Study on basis therapeutic exposures.We analyzed self-reported conditions 14,290 5-year Study, with a median 6 years (range, < 1 to 20 years) at diagnosis and 32 5 58 last follow-up. Identification high-risk exposures was adopted Children's Oncology Group Long-Term Follow-Up Guidelines. Cumulative incidence curves...
Abstract STUDY QUESTION Twenty years after the inception of first fertility preservation programme for pre-pubertal boys, what are current international practices with regard to cryopreservation immature testicular tissue? SUMMARY ANSWER Worldwide, tissue has been cryopreserved from over 3000 boys under age 18 a variety malignant and non-malignant indications; there is variability in related eligibility, clinical assessment, storage, funding. WHAT IS KNOWN ALREADY For male patients receiving...
The Childhood Cancer Survivor Study is a resource that was designed to investigate long-term effects among 5-year survivors of childhood and adolescent malignancies. Previous studies have shown exposure chemotherapy and/or radiation can compromise pulmonary function in these cancer.Using information obtained from questionnaires 12,390 cancer 3546 randomly selected siblings, the authors evaluated rate first occurrence 15 conditions three periods: during therapy, end therapy 5 years...
Gonadal damage is a consequence of therapy for pediatric malignancies. Prepubertal males have no semen or mature spermatozoa, posing challenge fertility preservation. Testicular tissue cryopreservation potential option but still experimental. We report on pilot protocol that offered testicular biopsy to families prepubertal boys with newly diagnosed malignancy. The aims were determine the acceptability and safety this procedure. Parents diagnoses at highest risk treatment-related gonadal...
In the human testis, beginning at ≈2 months of age, gonocytes are replaced by adult dark (Ad) and pale (Ap) spermatogonia that make up spermatogonial stem cell (SSC) pool. mice, SSC pool arises from ≈6 days after birth. During puberty in both species, complete spermatogenesis is established cells differentiate SSCs. Essentially pure populations prepubertal mouse were selected testis biopsies validated confirming presence specific marker proteins cells. Stem potential germ was demonstrated...
The survival of Ewing sarcoma (ES) patients has improved since the 1970s but is associated with considerable future health risks. study population consisted long-term (≥5-year) survivors childhood ES diagnosed before age 21 from 1970 to 1986. Cause-specific mortality was evaluated in eligible (n = 568), and subsequent malignant neoplasms, chronic conditions, infertility, status were subset participating Childhood Cancer Survivor Study 403). Outcomes compared US sibling control subjects...
Infertility is often a complication for adolescent and young adult males who receive cancer therapy, problem that might be averted through using cryopreserved sperm. We aim to evaluate feasibility of offering newly diagnosed patients the opportunity bank sperm and, determine beliefs decision-making processes their parents considered banking.Eligible were approached offered cryopreservation. Semen samples from sequentially attempted banking analyzed. Questionnaires then administered had been...
The strong dose-dependent association between anthracyclines and cardiomyopathy is further exacerbated by the co-occurrence of cardiovascular risk factors (diabetes hypertension). high morbidity associated with necessitates an understanding underlying pathogenesis so that targeted interventions can be developed.By using a two-stage design, we investigated host susceptibility to anthracycline-related ITMAT/Broad CARe single nucleotide polymorphism (SNP) array profile common SNPs in 2,100...
That too few youth with special health care needs make the transition to adult-oriented successfully may be due, in part, lack of readiness transfer care. There is a theoretical models guide development and implementation evidence-based guidelines, assessments, interventions improve readiness.To further validate Social-ecological Model Adolescent Young Adult Readiness Transition (SMART) via feedback from stakeholders (patients, parents, providers) medically diverse population need life-long...
Interindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests that genetic susceptibility could play a role. The current study uses an agnostic approach to identify variants modify risk.
Maintenance of adult tissues depends on stem cell self-renewal in local niches. Spermatogonial cells (SSC) are germline necessary for spermatogenesis and fertility. We show that testicular endothelial (TECs) part the SSC niche producing glial line-derived neurotrophic factor (GDNF) other factors to support human mouse SSCs long-term culture. demonstrate FGF-2 binding FGFR1 TECs activates calcineurin pathway produce GDNF. Comparison TEC secretome lung liver identified 5 sufficient maintenance...
BACKGROUND Survivors of childhood cancer are at risk nonsurgical premature menopause (NSPM). To the authors' knowledge, factors for NSPM and its impact on reproduction remain poorly defined. METHODS The menopausal status 2930 survivors diagnosed between 1970 1986 (median age, 6 years [range, birth‐20 years]) who were aged > 18 time current study 35 18‐58 was compared with 1399 siblings. defined as cessation menses ≥6 months in duration occurring 5 after diagnosis before age 40 that not...
Adolescent and young adult survivors of childhood cancer (AYA) are at risk for treatment-related late effects (eg, heart lung problems) which may be mitigated by physical activity (PA). To design effective, tailored PA interventions this population, predictors benefits behavior need to measured in real-time. examine the feasibility acceptability ecological momentary assessment (EMA) combined with accelerometry explore dynamic associations between real-time psychosocial factors among AYA. AYA...
PURPOSE: There are a variety of solid tumors in which alternative chromosomal translocations generate related fusion products. In alveolar rhabdomyosarcoma and synovial sarcoma, these variant fusions have been found to major clinical significance. We investigated whether the two gene products, EWS-FLI1 EWS-ERG, define different subsets within Ewing's sarcoma family tumors. PATIENTS AND METHODS: selected 30 cases with EWS-ERG 106 fusion. Clinical data were obtained for each case compared...