A5100432108- Topic Modeling
- Natural Language Processing Techniques
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Speech and dialogue systems
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac pacing and defibrillation studies
- Radiomics and Machine Learning in Medical Imaging
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Risk Factors
- Childhood Cancer Survivors' Quality of Life
- Lipid metabolism and disorders
- Ion channel regulation and function
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Multimodal Machine Learning Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Pulmonary Hypertension Research and Treatments
- Cancer Treatment and Pharmacology
- Acute Lymphoblastic Leukemia research
- Advanced Manufacturing and Logistics Optimization
- Optimization and Packing Problems
Shanghai Jiao Tong University
2015-2025
Ruijin Hospital
2020-2024
Capital Medical University
2019-2024
Shanghai Chest Hospital
2018-2024
Zhongda Hospital Southeast University
2024
Union Hospital
2024
Huazhong University of Science and Technology
2013-2024
Renji Hospital
2020-2024
Xiamen University
2024
Soochow University
2020-2024
Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) δ is the predominant cardiac isoform, and C splice variant cytoplasmic. We overexpressed CaMKIIδ in mouse heart observed dilated failure altered myocyte regulation 3-month-old transgenic mice (TG) versus wild-type littermates (WT). Heart/body weight ratio cardiomyocyte size were increased about 2-fold TG WT. At 1 Hz, twitch shortening, [Ca ] i transient amplitude, diastolic all reduced by ≈50% This explained >50% reduction SR content...
Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic alcohol metabolites. Polymorphisms in CBR1 and CBR3 influence synthesis these We examined whether single nucleotide polymorphisms (CBR1 1096G>A) and/or (CBR3 V244M) modified the dose-dependent risk anthracycline-related cardiomyopathy childhood cancer survivors.One hundred seventy survivors with (patient cases) were compared 317 no (controls; matched on diagnosis, year length follow-up, race/ethnicity) using...
To determine the oncologic efficacy, cardioprotective effectiveness, and safety of dexrazoxane added to chemotherapy that included a cumulative doxorubicin dose 360 mg/m(2) treat children adolescents with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) or non-Hodgkin lymphoma (L-NHL).Patients were treated on Pediatric Oncology Group Protocol POG 9404, which random assignment treatment without given as bolus infusion immediately before every doxorubicin. Cardiac effects assessed...
Dialogue state tracking (DST) aims at estimating the current dialogue given all preceding conversation. For multi-domain DST, data sparsity problem is also a major obstacle due to increased number of candidates. Existing approaches generally predict value for each slot independently and do not consider relations, which may aggravate problem. In this paper, we propose Schema-guided State Tracker with graph attention networks (SST) that predicts states from utterances schema graphs contain...
The predominant cardiac Ca2+/calmodulin-dependent protein kinase (CaMK) is CaMKIIdelta. Here we acutely overexpress CaMKIIdeltaC using adenovirus-mediated gene transfer in adult rabbit ventricular myocytes. This circumvents confounding adaptive effects transgenic mice. expression and activation state (autophosphorylation) were increased 5- to 6-fold. Basal twitch contraction amplitude kinetics (1 Hz) not changed versus LacZ expressing However, the contraction-frequency relationship was more...
Human Enterovirus 71 (EV71) and Coxsackievirus B3 (CVB3) have high risks for morbidity mortality. A virus quantitation immunoassay has been proposed by employing two colored quantum dots (QDs), antibodies of the virus, graphene oxide (GO). The QDs are streptavidin-conjugated (SA-QDs), biotinylated antibodies. Biotinylated EV71 antibody (Ab1) was associated with 525 nm green SA-QDs via biotin-streptavidin interaction forming QDs-Ab1, whereas CVB3 (Ab2) 605 red QDs-Ab2. GO an excellent...
Abstract Statins are effective cholesterol-lowering drugs. Lovastatin, one of the precursors statins, is formed from dihydromonacolin L (DML), which synthesized by lovastatin nonaketide synthase (LovB), with assistance a separate trans -acting enoyl reductase (LovC). A full DML synthesis comprises 8 polyketide synthetic cycles about 35 steps. The assembling LovB–LovC complex, and structural basis for iterative yet permutative functions megasynthase have remained mystery. Here, we present...
Although blood flow is restored after treatment of myocardial infarction (MI), ischemia and reperfusion (I/R) can cause cardiac injury, which a leading heart failure. Gastrodin (GAS) exerts protective effects against brain, heart, kidney I/R. However, its pharmacological mechanism in I/R injury (MIRI) remains unclear. GAS regulates autophagy various diseases, such as acute hepatitis, vascular dementia, stroke. We hypothesized that could repair mitochondrial damage regulate to protect MIRI....
Concerns about long-term methotrexate (MTX) neurotoxicity in the 1990s led to modifications intrathecal (IT) therapy, leucovorin rescue, and frequency of systemic MTX administration children with acute lymphoblastic leukemia. In this study, neurocognitive outcomes neuroradiologic evidence leukoencephalopathy were compared treated intense central nervous system (CNS)-directed therapy (P9605) versus those receiving fewer CNS-directed treatment days during intensive consolidation (P9201). A...
This study aimed to develop and optimize a novel biochar-based fertilizer composed of rice husk biochar urea–hydrogen peroxide (UHP), which can simultaneously slowly release nitrogen immobilize cadmium (Cd). Response surface methodology (RSM) was adopted the formulation with lowest rate. Under optimized conditions, cumulative rate 17.63%, significantly lower than that ordinary fertilizer. Elementary analysis, scanning electron microscopy (SEM) images, Fourier transform infrared (FTIR)...
Abstract Chronic hepatitis B (CHB) is a global epidemic disease that may progress to fibrosis, cirrhosis and hepatocellular carcinoma. The role of the liver‐bile acid‐microbiota axis in CHB remains unclear. aims this study are elucidate alteration gut microbiota its functions bile acid homeostasis patients with different degrees fibrosis. In present study, we evaluated serum faecal profiles healthy controls biopsy‐proven diagnosis: had stage 0‐1 fibrosis were classified as mild 2‐4...
Left bundle branch area pacing (LBBAP) includes left (LBBP) and ventricular (LV) septal myocardial (LVSP).The study aimed to assess resynchronization effects clinical outcomes by LBBAP in heart failure (HF) patients with cardiac therapy (CRT) indications.LBBAP was successfully performed 29 consecutive further classified as the LBBP-group (N = 15) LVSP-group 14) based on LBBP criteria novel LV conduction time measurement (LV CT, between site (LVP) site). AV-interval optimized or LVSP, LVSP...
AbstractAn integrated single-machine group scheduling model is proposed, which incorporates both learning and forgetting effects preventive maintenance (PM) planning. The objective to minimise the expected makespan by optimising job sequence PM decisions. This contains sequence-dependent set-up time, actual processing planned time minimal repair simultaneously. Based on properties of production, three functions under different circumstances are proposed deduce variable each part, considering...
Introduction Left ventricular ejection fraction (LVEF) ≤35%, as current significant implantable cardioverter-defibrillator (ICD) indication for primary prevention of sudden cardiac death (SCD) in heart failure (HF) patients, has been widely recognised to be inefficient. Improvement patient selection low LVEF (≤35%) is needed optimise deployment ICD. Most the existing prediction models are not appropriate identify ICD candidates at high risk SCD HF patients with LVEF. Compared traditional...
Text simplification (TS) rephrases long sentences into simplified variants while preserving inherent semantics. Traditional sequence-to-sequence models heavily rely on the quantity and quality of parallel sentences, which limits their applicability in different languages domains. This work investigates how to leverage large amounts unpaired corpora TS task. We adopt back-translation architecture unsupervised machine translation (NMT), including denoising autoencoders for language modeling...
Cardiovascular disease (CVD) is a major complication of type 2 diabetes mellitus (T2DM). In addition to traditional risk factors, psychological determinants play an important role in CVD risk. This study applied Deep Neural Network (DNN) develop prediction model and explored the bio-psycho-social contributors among patients with T2DM. From 2017 2020, 834 T2DM were recruited from Department Endocrinology, Affiliated Hospital Harbin Medical University, China. this cross-sectional study,...
The detection of genetically modified organisms (GMOs) is crucial for regulatory compliance and consumer safety. This study presents a novel method combining loop-mediated isothermal amplification (LAMP) with CRISPR/Cas12a cleavage, termed Cas-pfLAMP, sensitive specific GMO detection. We developed assays three GM events: maize DBN9936 MON810 soybean GTS40-3-2. By incorporating universal protospacer adjacent motif (PAM) sequence into LAMP primers, we overcame the limitations PAM site...
Background Aboriginal populations are at substantially higher risks of adverse birth outcomes, perinatal and infant mortality than their non-Aboriginal counterparts even in developed countries including Australia, U.S. Canada. There is a lack data on recent trends Methods We conducted population-based retrospective cohort study (n = 254,410) using the linked vital events registry databases for singleton births Quebec 1996–2010. (First Nations, Inuit) were identified by mother tongue, place...
Naoxintong (NXT), a prescribed traditional Chinese medicine, widely used in cerebrovascular and cardiovascular diseases, could be effective diabetic wounds.This study evaluates the wound healing activity of NXT by employing an excisional splinting model.NXT was dissolved saline given daily gavage. Wounds were induced at dorsum non-diabetic (db/+) (db/db) mice treated with or 700 mg/kg/d for 16 days. Wound closure measured every four Extracellular matrix (ECM) remodelling, collagen...