A5029799035- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Menopause: Health Impacts and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- Reproductive Health and Contraception
- Endometriosis Research and Treatment
- Menstrual Health and Disorders
- Prenatal Screening and Diagnostics
- Sexual Differentiation and Disorders
- Hormonal and reproductive studies
- BRCA gene mutations in cancer
- Estrogen and related hormone effects
- Gestational Trophoblastic Disease Studies
- Sperm and Testicular Function
- Cardiovascular Issues in Pregnancy
- Uterine Myomas and Treatments
- Phytoestrogen effects and research
- Sexual function and dysfunction studies
- Pregnancy and Medication Impact
Hospital of the University of Pennsylvania
2016-2025
University of Pennsylvania
2015-2025
University of Pennsylvania Health System
2022-2025
American Society for Reproductive Medicine
2017-2024
Johns Hopkins University
2018
Cleveland Clinic
2018
University School
2018
University of Michigan
2017
Princess Máxima Center
2016
Wilhelmina Children's Hospital
2016
Associations between depressed mood and hormonal changes during transition to menopause are controversial. To our knowledge, there has been no prospective study of these associations in women commencing when they premenopausal.To longitudinally the among reproductive hormones, menopausal status, other predictors midlife women.Cohort with 6 assessment periods a 4-year interval. Blood samples were collected 12 times follicular phase (days 2-6).Philadelphia County, Pennsylvania.A randomly...
In Brief OBJECTIVE: To test the hypothesis that prevalence of women with menopausal symptoms hot flushes; aches, joint pain, and stiffness; depressed mood; poor sleep; decreased libido; or vaginal dryness increases progression through transition. METHODS: Women in Penn Ovarian Aging Study were assessed longitudinally for 9 years. Data obtained from structured interviews, a validated symptom questionnaire, menstrual bleeding dates early follicular hormone measures (estradiol [E2],...
Anti-mullerian hormone (AMH) has emerged as a marker of ovarian reserve and possible surrogate measure reproductive aging.The aim the study was to evaluate predictive value AMH levels in determining median time menopause for late age women ability compared FSH inhibin b.A 14-yr follow-up Penn Ovarian Aging Study, 1996-2010, conducted randomly identified population-based cohort.A total 401 participated study.Observed measured.All participants were premenopausal, with mean (SD) 41.47 (3.52) yr...
What progress has been made in fertility preservation (FP) over the last decade?FP techniques have widely adopted decade and therefore establishment of international registries on their short- long-term outcomes is strongly recommended.FP a fundamental issue for both males females whose future may be compromised. Reproductive capacity seriously affected by age, different medical conditions also treatments, especially those with gonadal toxicity. There general consensus need to provide...
In Brief Objective: Several menopausal staging definitions are currently being used in ongoing studies designed to identify changes occurring during menopause. The objective of this study was determine which definition captures the earliest hormonal transition. Design: prospective cohort study, women aged 35 47 years were followed for 5 years. Women classified as premenopausal, early transition, late and postmenopausal by 2 different systems defined bleeding patterns. Definitions from Study...
The aim of this study was to estimate associations obesity with reproductive hormone levels as women progress from premenopausal postmenopausal status.This a longitudinal conducted in the population-based Penn Ovarian Aging Cohort (N = 436). At cohort enrollment, were premenopausal, ages 35 47 years, equal numbers African Americans and whites. Anthropometric measures, menopause status, measures evaluated for 12 years. Associations anthropometric estradiol, follicle-stimulating hormone,...
In Brief Objective: To estimate the association of anxiety with menopausal hot flashes in early transition to menopause. Design: A randomly identified, population-based cohort midlife women followed up for 6 years assess reproductive hormones and other physical, emotional, behavioral factors. At enrollment, were premenopausal, aged 35 47 years, had regular menstrual cycles normal range. Enrollment was stratified obtain equal numbers African American (n = 219) white 217) women. Results:...
In Brief OBJECTIVE: To estimate the duration of moderate-to-severe menopausal hot flushes and identify potential risk factors for flush duration. METHODS: The Penn Ovarian Aging Study cohort was monitored 13 years. Hot were evaluated at 9-month to 12-month intervals through in-person interviews. primary outcome estimated by survival analysis (n=259). Potential included stage, age, race, reproductive hormone levels, body mass index (BMI), current smoking. A secondary women who reported any...
In Brief OBJECTIVE: To examine the relationship between reproductive hormonal dynamics and sexual dysfunction assessed in a cohort of women approaching menopause. METHODS: Women Penn Ovarian Aging Study were at yearly intervals for 3 years with early follicular hormone measurements (estradiol, follicle-stimulating hormone, luteinizing [LH], sex binding globulin, dehyroepiandrosterone sulfate [DHEAS], total testosterone), anthropometric measures, extensive questionnaires including Female...