A5049231667- Veterinary Oncology Research
- Virus-based gene therapy research
- Infectious Diseases and Mycology
- Microbial infections and disease research
- Cancer Research and Treatments
- Reproductive tract infections research
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Diabetes and associated disorders
- Cell Adhesion Molecules Research
- Veterinary Medicine and Surgery
- Clostridium difficile and Clostridium perfringens research
- Pancreatic function and diabetes
- Parasitic Infections and Diagnostics
- Sarcoma Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Cancer and Skin Lesions
- Viral gastroenteritis research and epidemiology
- Helminth infection and control
- Human-Animal Interaction Studies
- Mycobacterium research and diagnosis
- Hedgehog Signaling Pathway Studies
University of Zurich
2016-2025
Universidade Estadual Paulista (Unesp)
2022
University of Trás-os-Montes and Alto Douro
2022
Universidade do Porto
2022
Universidade de São Paulo
2022
University of Naples Federico II
2022
Veterinary Research Institute
2007
Stanford University
2002-2005
Moredun Research Institute
1996
Medizinische Hochschule Hannover
1994
This study is based on the Swiss Canine Cancer Registry, comprising 121,963 diagnostic records of dogs compiled between 1955 and 2008, in which 63,214 (51.83%) animals were diagnosed with tumour lesions through microscopical investigation. Adenoma/adenocarcinoma (n = 12,293, 18.09%) was most frequent diagnosis. Other common diagnoses were: mast cell 4,415, 6.50%), lymphoma 2,955, 4.35%), melanocytic tumours 2,466, 3.63%), fibroma/fibrosarcoma 2,309, 3.40%), haemangioma/haemangiosarcoma...
Monitoring neoplasms in standardized registries facilitates epidemiologic studies of risk factors for tumor development and predisposition. In an observational study, we determined incidence rates (IR) malignant rate ratios (IRR) by age, sex, breed Swiss dogs using demographic data from the official dog registration database Amicus. The dataset analyzed included 54'986 tumors diagnosed histology cytology four veterinary pathology laboratories between 2008 2020. Diagnoses were coded according...
Allogeneic hematopoietic cell transplantation (allo-HCT) not only is an effective treatment for several hematologic malignancies but can also result in potentially life-threatening graft-versus-host disease (GvHD). GvHD caused by T cells within the allograft attacking nonmalignant host tissues; however, these same mediate therapeutic graft-versus-leukemia (GvL) response. Thus, there urgent need to understand how mechanistically uncouple GvL from GvHD. Using preclinical models of full and...
Data collected in animal cancer registries comprise extensive and valuable information, even more so when evaluated context with precise population data. The authors 11 740 canine skin tumors the Swiss Canine Cancer Registry from 2008-2013, considering data on breed, sex, age, anatomic locations. Their incidence rate (IR) per 100 000 dogs/year dog was calculated based official mandatory registration database ANIS. most common tumor types were mast cell (16.35%; IR, 60.3), lipomas (12.47%;...
Cancer registries are valuable sources for epidemiological research investigating risk factors underlying different types of cancer incidence. The present study is based on the Swiss Feline Registry that comprises 51,322 feline patient records, compiled between 1965 and 2008. In these 18,375 tumours were reported. analyses influence sex, neutering status, breed, time age development most common tumour their locations, using a multiple logistic regression model. largest differences breeds...
We retrospectively evaluated predictive prognostic factors in 73 cats with vaccine-associated sarcoma given postsurgical curative (n = 46, most clean margins) or coarse fractionated radiotherapy 27, either macroscopic disease dirty margins). The former animals displayed a median survival of 43 months and progression free interval (PFI) 37 months, the latter reached 24 PFI 10 months. In undergoing therapy, better outcome included lack visible mass 10) as opposed to 17, survival: 30 versus 7 P...
Endocrine mechanisms governing canine reproductive function remain still obscure. Progesterone (P4) of luteal origin is required for maintenance pregnancy. Corpora lutea (CL) are gonadotrop-independent during the first third dioestrus; afterwards prolactin (PRL) primary luteotropic factor. Interestingly, increasing PRL levels accompanied by decreasing P4 concentrations, thus regression/luteolysis occurs in spite an increased availability gonadotropic support. acts through its receptor...
Aelurostrongylus abstrusus infection is common in endemic areas and may cause severe respiratory clinical signs. Computed tomography (CT) an important tool to diagnose pulmonary disease, because it allows detection of small lesions discrimination superimposed structures. The purpose this study was characterize by CT angiographic the six cats before, 48 81 days after inoculation with 100 or 800 A. infective larvae. Histological examination accessory lung lobe performed determine microscopic,...
Abstract Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. With high mutation load large number of altered genes, strategies to delineate key driver events are necessary. Dogs cats develop urothelial carcinoma (UC) histological clinical similarities human MIBC. Cattle that graze on bracken fern also UC, exposure the carcinogen ptaquiloside. These species may represent relevant animal models spontaneous carcinogen-induced UC...
Infections with herpesviruses may cause papillomatous lesions in the as well African elephant.* In both, virus was reported to localize only skin. Disseminated nodules of epithelial cells were found lungs ofa high percentage ofwild elephant^.^ these cases, proliferated contained intranuclear inclusion bodies which herpesvirus particles observed by electron microscopy. The virus, however, caused no illness, and there generalization. We report necropsy findings a juvenile Asian elephant dying...
Abstract Canine urothelial carcinoma (UC) and prostate (PC) frequently exhibit the BRAF V595E mutation, akin to V600E mutation common in various human cancers. Since initial discovery of canine cancers 2015, PCR has been standard method for its detection both liquid tissue biopsies. Considering similarity between mutations, we hypothesized that immunohistochemistry (IHC) using a ‐specific antibody could effectively identify mutant protein. We tested 122 UC (bladder n = 108, urethra 14), 21...
The purpose of this study was to determine the position, appearance and dimensions abomasum 50 healthy 4 cows by ultrasonography. ventral abdominal region caudal xiphoid process examined with a 3.5 MHz linear 5 transducer. could be visualised from both sides 2 midline 47 cows. clearly differentiated adjacent organs because its contents, which appeared as heterogeneous, moderately echogenic structure stippling. However, wall appeared, if at all, narrow line. Parts abomasal folds were visible...
Abstract The hair follicle has a lifelong capacity to cycle through recurrent phases of controlled growth (anagen), regression (catagen) and quiescence (telogen), each associated with specific morphological changes. A comprehensive classification scheme is available for mice distinguish the stages anagen I–VI, catagen I–VIII telogen. For dogs, such system does not exist, although alopecia arrest common. We applied analogous criteria various staining techniques subdivide canine same extent as...
Background: Progesterone receptor (PR) antagonist aglepristone (RU534) has been used successfully for pregnancy termination and therapy of pyometra, vaginal tumors, mammary hyperplasia in bitches queens. All these conditions share with canine carcinomas the expression PR. Objectives: To study effect RU534 on proliferation apoptosis relation to PR expression. Animals: Twenty‐seven nonspayed were treated either 2 doses 20 mg/kg (n = 22, RU534‐treated group) or oil placebo 5, control days 1 8....
Acute inflammation in humans is associated with transient insulin resistance (IR) and dyslipidemia. Chronic low-grade a pathogenic component of IR adipose tissue dysfunction obesity-induced type 2 diabetes. Because feline diabetes closely resembles human diabetes, we studied whether lipopolysaccharide (LPS)-induced subacute inflammation, the absence obesity, potential primary cause metabolic disorders. Cats received increasing iv doses (10–1000 ng/kg−1 · h−1) LPS (n = 5) or saline for 10 d....
Pancreatic amyloidosis and loss of α β cells have been shown to occur in cats with diabetes mellitus, although the number studies currently available is very limited. Furthermore, it not known whether pancreatic islet inflammation a common feature. The aims present study were characterize lesions investigate diabetic islets. Samples pancreas collected postmortem from 37 20 control matched for age, sex, breed, body weight. Histologic sections stained hematoxylin eosin Congo red; double...
Cancer registries are fundamental tools for collecting epidemiological cancer data and developing prevention control strategies. While registration is common in the human medical field, many attempts to develop animal have been launched over time, but most discontinued. A pivotal aspect of availability coding systems, as provided by International Classification Diseases Oncology (ICD-O). Within Global Initiative Veterinary Surveillance (GIVCS), established foster coordinate worldwide, a...